Dopaminergic and serotonergic modulation of social reward appraisal in zebrafish (Danio rerio) under circumstances of motivational conflict: Towards a screening test for anti-compulsive drug action

Staden, Chanel Van; Brouwer, Geoffrey de; Botha, Tarryn L.; Finger‐Baier, Karin; Brand, Sarel J.; Wolmarans, De Wet

doi:10.1016/j.bbr.2019.112393

Cited by 7 publications

(15 citation statements)

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“…This animal model displays relevant traits that makes it a very powerful tool: fast development, high fecundity that provides a large number of individuals, cheap maintenance, and ease of manipulation [1]. Zebrafish also exhibits a variety of complex brain-related behaviours that are believed to parse human behaviours such as learning, attention, memory, aggression, reward, anxiety, and stress [2][3][4][5][6][7][8][9]. Among these, anxiety [10][11][12] and reward [13,14] are the most relevant ones for the characterisation of substances of abuse.…”

Section: Introductionmentioning

confidence: 99%

Nicotinic Antagonist UFR2709 Inhibits Nicotine Reward and Decreases Anxiety in Zebrafish

et al. 2020

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Zebrafish is becoming a popular animal model in neuropharmacology and drug discovery, mainly due to its ease of handling and low costs involved in maintenance and experimental work. This animal displays a series of complex behaviours that makes it useful for assessing the effects of psychoactive drugs. Here, adult zebrafish were used for assessment of the anxiolytic and anti-addictive properties of UFR2709, a nicotinic receptor (nAChR) antagonist, using two behavioural paradigms to test for addiction, the novel tank diving test to assess anxiety and the conditioned place preference (CPP). Furthermore, the expression of nAChR subunits α4 and α7 was measured in the zebrafish brain. The results show that UFR2709 exhibits an anxiolytic effect on zebrafish and blocks the effect evoked by nicotine on CPP. Moreover, UFR2709 significantly decreased the expression of α4 nicotinic receptor subunit. This indicates that UFR2709 might be a useful drug for the treatment of nicotine addiction.

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Section: Introductionmentioning

confidence: 99%

Nicotinic Antagonist UFR2709 Inhibits Nicotine Reward and Decreases Anxiety in Zebrafish

et al. 2020

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“…A consistent result was obtained in a previous study, which used the color red as an aversive cue paired with a social cue. Here, subjects initially did not approach the cue, but this trend could be reversed using dopaminergic and serotonergic manipulation (van Staden et al, 2020). A conflict could also be generated between two rewards, in which zebrafish show a less vigorous, but a more persistent tendency to approach a social reward compared to food (Daggett et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

Acute stress modulates social approach and social maintenance in adult zebrafish

Beckmann

Cook

Azap

et al. 2023

Preprint

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Stress alters social functioning in a complex manner. An important variable determining the final effects of stress is stressor intensity. However, the precise relationship between stressor intensity and social behavior is not well understood. Here we investigate the effects of varying acute stressor intensity exposure on social behavior using adult zebrafish. We first establish a novel test using adult zebrafish that allows distinguishing fish's drive to approach a social cue and its ability to engage and maintain social interaction within the same behavioral paradigm. Next, we combined this test with a new method to deliver an acute stress stimulus or varying intensities. Our results show that both social approach and social maintenance are reduced in adult zebrafish upon acute stress exposure in an intensity-dependent manner. Interestingly, lower stress intensity reduces social maintenance without affecting the social approach, while a higher stress level is required to alter social approach. These results provide evidence for a direct correlation between acute stressor intensity and social functioning and suggest that distinct steps in social behavior are modulate differentially by the acute stress level.

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“…Although cannabis remains by far the most commonly used/abused drug, opioids present the greatest harm to the health of users [ 16 ]. Importantly, zebrafish possess all opioid [ 17 , 18 , 19 ], cannabinoid [ 20 ], and monoaminergic systems [ 21 , 22 , 23 ] that play a key role in drug-induced psychiatric disorders.…”

Section: Current State Of Studying Zebrafish Model Of Psychiatric Dis...mentioning

confidence: 99%

Current State of Modeling Human Psychiatric Disorders Using Zebrafish

Costa

Колесникова

Galstyan

et al. 2023

IJMS

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Psychiatric disorders are highly prevalent brain pathologies that represent an urgent, unmet biomedical problem. Since reliable clinical diagnoses are essential for the treatment of psychiatric disorders, their animal models with robust, relevant behavioral and physiological endpoints become necessary. Zebrafish (Danio rerio) display well-defined, complex behaviors in major neurobehavioral domains which are evolutionarily conserved and strikingly parallel to those seen in rodents and humans. Although zebrafish are increasingly often used to model psychiatric disorders, there are also multiple challenges with such models as well. The field may therefore benefit from a balanced, disease-oriented discussion that considers the clinical prevalence, the pathological complexity, and societal importance of the disorders in question, and the extent of its detalization in zebrafish central nervous system (CNS) studies. Here, we critically discuss the use of zebrafish for modeling human psychiatric disorders in general, and highlight the topics for further in-depth consideration, in order to foster and (re)focus translational biological neuroscience research utilizing zebrafish. Recent developments in molecular biology research utilizing this model species have also been summarized here, collectively calling for a wider use of zebrafish in translational CNS disease modeling.

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Dopaminergic and serotonergic modulation of social reward appraisal in zebrafish (Danio rerio) under circumstances of motivational conflict: Towards a screening test for anti-compulsive drug action

Cited by 7 publications

References 115 publications

Nicotinic Antagonist UFR2709 Inhibits Nicotine Reward and Decreases Anxiety in Zebrafish

Nicotinic Antagonist UFR2709 Inhibits Nicotine Reward and Decreases Anxiety in Zebrafish

Acute stress modulates social approach and social maintenance in adult zebrafish

Current State of Modeling Human Psychiatric Disorders Using Zebrafish

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