Dopaminergic alterations in populations at increased risk for psychosis: A systematic review of imaging findings

Hooijdonk, Carmen F M van; Drukker, Marjan; Giessen, Elsmarieke van de; Booij, Jan; Selten, Jean-Paul; Amelsvoort, Thérèse van

doi:10.1016/j.pneurobio.2022.102265

Cited by 6 publications

(1 citation statement)

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“…This supports previous research of the P3a responses in PD (Seer et al, 2016; Solís-Vivanco et al, 2015; Tsuchiya et al, 2000), and schizophrenia (Bestelmeyer, 2012; Fisher, Labelle, & Knott, 2010); where striatal dopamine is abnormally low and high, respectively. Reduced P3a amplitudes and increased striatal dopamine synthesis capacity have also been observed in individuals at risk of developing psychosis (Mondragón-Maya et al, 2013; van Hooijdonk et al, 2022). As such, problems with temporal processing observed in these disorders are likely related to abnormal striatal dopamine levels, rather than other aspects of the illnesses or their comorbidities.…”

Section: Discussionmentioning

confidence: 99%

Striatal Dopamine Modulates Temporal Surprise P3a

Whitaker,

Schwartze,

Martin

et al. 2024

Preprint

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Dopamine is vital in forming mental models of 'what' and 'when' sensory events occur that essentially guide goal-directed behaviour. However, it remains largely unknown how variations in temporal predictability are incorporated into such mental models. A better understanding of the underlying mechanisms is important, considering dopaminergic depletion in diseases such as Parkinson's Disease and Schizophrenia, where abnormal temporal processing is observed. Some electroencephalographic (EEG) studies indicate that noradrenergic mechanisms, as reflected in the P3b event-related potential, are modulated by temporal predictability, whereas others indicate that dopaminergic mechanisms as reflected in the P3a, underlie surprise. In this study, resting-state and task-dependent EEG was recorded from 24 healthy participants who were administered a selective D2 agonist or antagonist before they performed a pure tone auditory 'oddball' task. Two oddball sequences included either partially predictable, with inter-stimulus intervals (ISIs) of 400ms/1200ms; or fully temporally predictable tones, with a consistent ISI of 600ms. Tones following 400ms ISIs were perceived as surprising, or 'early', as shown in an enhanced P3a response; tones following a 1200ms ISIs showed a much reduced P3a response ('late'). The agonist accentuated the 'late' effect, demonstrating that drugs targeting D2 receptors modulate temporal prediction. These findings differentiate the role of the dopaminergic system in temporal processing and model-based auditory predictions.

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