Dopamine β‐hydroxylase gene associates with stroop color‐word task performance in Han Chinese children with attention deficit/hyperactivity disorder

Abstract

The cognitive deficits observed in attention deficit/hyperactivity disorder (ADHD) are candidate endophenotypes for genetic association studies. Dopamine β-hydroxylase (DβH) converts dopamine to norepinephrine, and its activity is under strong genetic control. Prior studies suggest association between ADHD and DBH gene. The present study examined associations between a putative functional single nucleotide polymorphism (SNP) at DBH with performance on the Stroop task in patients with ADHD and in healthy control subjects. A total of 812 Han Chinese youths with DSM-IV ADHD and 233 unaffected controls were included in the study. Comprehensive phenotype data were collected, including performance on a series of Stroop interference tests examining inhibition of response to interfering stimuli. DBH SNP -1021C/T was genotyped using the 5'-exonuclease (TaqMan®) method. Compared to unaffected controls, children with ADHD performed significantly worse in all categories of the Stroop test. In ADHD cases, DBH genotype at -1021C/T significantly associates with reaction times of incongruent color word parts but not the interference times, with TT genotype performing significantly better in both reaction time and interference time than other two genotype groups. DBH genotype did not associate with cognitive performance in unaffected controls or in the combined group. DBH genotype at -1021C/T associates with differences in performance on the Stroop task in children with ADHD.

Evaluation of a Predictive Algorithm that Detects Aberrant Use of Opioids in an Addiction Treatment Centre

“…Cocaine Addiction [29,30] ADHD [31] Schizophrenia Measures of the POR's performance included (1) sensitivity: the percentage of OUD patients correctly identified by POR scores, (2) specificity: the percentage of control patients correctly identified by POR scores, (3) positive predictive value (PPV): the percentage of patients who were identified as OUD by the POR and were actually OUD cases, (4) negative predictive value (NPV): the percentage of patients who were identified as healthy by the POR and were actually healthy controls. Logistic regression was used to assess the predictability of the OUD cases and controls given a POR score.…”

Monoaminergic Genetic Variants, Prefrontal Cortex–Amygdala Circuit, and Emotional Symptoms in Children With ADHD: Exploration Based on the Gene–Brain–Behavior Relationship

“…Validation in a larger sample size and genotyping for more genetic variants of serotonin system will definitely be needed. For variants of genes COMT (rs4680) and DBH (rs1611115), the negative association with EL might be a result of these functional variants mainly influencing PFC structure and function related to working memory (Jin et al, 2016) and/or inhibition (Ji et al, 2011), not the top-down regulation of the PFC on the amygdala. For the SNP MAOA-rs3788862, although no single SNP-based association was found, its interaction with NET1-rs3785143 on EL was found.…”

Deficiency of Sustained Attention in ADHD and Its Potential Genetic Contributor MAOA

“…All of the SNPs were genotyped using a Taqman allelic genotyping assay (Livak, 1999) on an ABI 7900HT instrument (Applied Biosystems, Foster City, CA, USA). Detailed experimental information for DBH, NET1 , and MAOA is given in our previous reports (Ji et al, 2011; L. Liu et al, 2015; L.…”