Dopamine transporter regulates the enhancement of novelty processing by a negative emotional context

García-García, Manuel; Clemente, Imma C.; Domínguez-Borràs, Judith; Escera, Carles

doi:10.1016/j.neuropsychologia.2010.01.018

Cited by 19 publications

(19 citation statements)

References 44 publications

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“…47 Also of note is a previous report suggesting 9 carriers to display enhanced detection of novel and behaviorally relevant signals as assessed by measuring auditory N1 potentials. 48 …”

Section: Discussionmentioning

confidence: 99%

Association between amygdala reactivity and a dopamine transporter gene polymorphism

et al. 2014

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Essential for detection of relevant external stimuli and for fear processing, the amygdala is under modulatory influence of dopamine (DA). The DA transporter (DAT) is of fundamental importance for the regulation of DA transmission by mediating reuptake inactivation of extracellular DA. This study examined if a common functional variable number tandem repeat polymorphism in the 3′ untranslated region of the DAT gene (SLC6A3) influences amygdala function during the processing of aversive emotional stimuli. Amygdala reactivity was examined by comparing regional cerebral blood flow, measured with positron emission tomography and [15O]water, during exposure to angry and neutral faces, respectively, in a Swedish sample comprising 32 patients with social anxiety disorder and 17 healthy volunteers. In a separate US sample, comprising 85 healthy volunteers studied with blood oxygen level-dependent functional magnetic resonance imaging, amygdala reactivity was assessed by comparing the activity during exposure to threatening faces and neutral geometric shapes, respectively. In both the Swedish and the US sample, 9-repeat carriers displayed higher amygdala reactivity than 10-repeat homozygotes. The results suggest that this polymorphism contributes to individual variability in amygdala reactivity.

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“…47 Also of note is a previous report suggesting 9 carriers to display enhanced detection of novel and behaviorally relevant signals as assessed by measuring auditory N1 potentials. 48 …”

Section: Discussionmentioning

confidence: 99%

Association between amygdala reactivity and a dopamine transporter gene polymorphism

et al. 2014

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“…This crucial function involves the DA system (Cools, 2008;Garcia-Garcia et al, 2010a;Garcia-Garcia et al, 2010b;Kaplan and Oudeyer, 2007;DA Lewis et al, 2001;Mehta et al, 2000;Sawaguchi and Goldman-Rakic, 1994) putatively through a reciprocal relationship between PFC and striatal DA (Akil et al, 2003;Meyer-Lindenberg et al, 2002). This interplay is thought to regulate the stability and flexibility of mental representations, maybe through the modulation of the firing of prefrontal pyramidal neurons, which is enhanced during maintenance in the delay period of a memory task (Durstewitz et al, 2000) and is modulated by the DA neurotransmitter through stimulation of D1 receptors at the PFC (Durstewitz et al, 2000;Durstewitz and Seamans, 2002;Sawaguchi and Goldman-Rakic, 1994).…”

Section: Discussionmentioning

confidence: 99%

COMT and ANKK1 gene–gene interaction modulates contextual updating of mental representations

et al. 2011

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“…Dopamine, brain regions rich in dopamine receptors, and genes involved in dopamine metabolism and signaling are all shown to be involved in emotion regulation and dysregulation (Alcaro, Huber, & Panksepp, 2007; Badgaiyan, Fischman, & Alpert, 2009; Beiderbeck et al, 2012; Garcia-Garcia, Clemente, Domínguez-Borràs, & Escera, 2010; Levita, Dalley, & Robbins, 2002; Opmeer, Kortekaas, & Aleman, 2010; Salgado-Pineda, Delaveau, Blin, & Nieoullon, 2005), including depression (Klimek, Schenck, Han, Stockmeier, & Ordway, 2002; Meyer et al, 2001; Roy, Karoum, & Pollack, 1992), as well as ADHD (Levy, 1991; Wender, 1971). For example, the 9/10 variable number tandem repeat (VNTR) in the 3’-untranslated region (UTR) of the dopamine transporter (DAT) gene ( DAT1/SLC6A3 ) was found to be associated with depression (Felten, Montag, Markett, Walter, & Reuter, 2011), anxiety (Gadow, Roohi, DeVincent, & Hatchwell, 2008), and processing negative emotional stimuli (Garcia-Garcia et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

“…For example, the 9/10 variable number tandem repeat (VNTR) in the 3’-untranslated region (UTR) of the dopamine transporter (DAT) gene ( DAT1/SLC6A3 ) was found to be associated with depression (Felten, Montag, Markett, Walter, & Reuter, 2011), anxiety (Gadow, Roohi, DeVincent, & Hatchwell, 2008), and processing negative emotional stimuli (Garcia-Garcia et al, 2010). It also evidences modest association with ADHD (Gizer, Ficks, & Waldman, 2009) as do other DAT1 variants including a VNTR on intron8 and the single nucleotide polymorphism (SNP) rs27072, but effect sizes across studies are generally heterogeneous.…”

Section: Introductionmentioning

confidence: 99%

Association of dopamine gene variants, emotion dysregulation and ADHD in autism spectrum disorder

Gadow

Pinsonneault

Perlman

et al. 2014

Research in Developmental Disabilities

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The aim of the present study was to evaluate the association of dopaminergic gene variants with emotion dysregulation (EMD) and attention-deficit/hyperactivity disorder (ADHD) symptoms in children with autism spectrum disorder (ASD). Three dopamine transporter gene (SLC6A3/DAT1) polymorphisms (intron8 5/6 VNTR, 3’-UTR 9/10 VNTR, rs27072 in the 3’-UTR) and one dopamine D2 receptor gene (DRD2) variant (rs2283265) were selected for genotyping based on à priori evidence of regulatory activity or, in the case of DAT1 9/10 VNTR, commonly reported associations with ADHD. A sample of 110 children with ASD was assessed with a rigorously validated DSM-IV-referenced rating scale. Global EMD severity (parents’ ratings) was associated with DAT1 intron8 (ηp2=0.063) and rs2283265 (ηp2=0.044). Findings for DAT1 intron8 were also significant for two EMD subscales, generalized anxiety (ηp2=0.065) and depression (ηp2=0.059), and for DRD2 rs2283265, depression (ηp2=0.053). DRD2 rs2283265 was associated with teachers’ global ratings of ADHD (ηp2=0.052). DAT1 intron8 was associated with parent-rated hyperactivity (ηp2=0.045) and both DAT1 9/10 VNTR (ηp2=0.105) and DRD2 rs2283265 (ηp2=0.069) were associated with teacher-rated inattention. These findings suggest that dopaminergic gene polymorphisms may modulate EMD and ADHD symptoms in children with ASD but require replication with larger independent samples.

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Dopamine transporter regulates the enhancement of novelty processing by a negative emotional context

Cited by 19 publications

References 44 publications

Association between amygdala reactivity and a dopamine transporter gene polymorphism

Association between amygdala reactivity and a dopamine transporter gene polymorphism

COMT and ANKK1 gene–gene interaction modulates contextual updating of mental representations

Association of dopamine gene variants, emotion dysregulation and ADHD in autism spectrum disorder

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