Dopamine system, cerebellum, and nucleus ruber in fish and mammals

Matsui, Hirokazu

doi:10.1111/dgd.12357

Cited by 27 publications

(21 citation statements)

References 118 publications

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“…BPA has previously been shown to affect dopaminergic pathways in mammals [25,26], and we showed here that DEGs involved in dopaminergic pathways were deregulated in goldfish after BPA exposure. To determine whether BPA affected dopaminergic production and dopaminergic neurons in goldfish in vivo, we examined the effects of BPA exposure on serum dopamine concentrations and stained brain sections with TUNEL.…”

Section: Analysis Of Dopamine Concentrations and Brain Dopaminergic Nsupporting

confidence: 64%

“…In the treatment group, positive TUNEL staining was found in the diencephalon area, the main site of dopaminergic neuron distribution ( Figure 6D,F,H), and the number of TUNEL-positive cells per unit area was also higher in the BPA treatment group ( Figure 6I-K), but no positive signals were observed in the corresponding area in the control group ( Figure 6C,E,G). The main dopaminergic neuron distribution area has been described by Matsui [26] and Schweitzer [27]. The dorsal view of the fish brain is shown in Figure 6A, and the longitudinal sectional view is shown in Figure 6B.…”

Section: Analysis Of Dopamine Concentrations and Brain Dopaminergic Nmentioning

confidence: 86%

“…As described in the Introduction Section, the effects of BPA on dopaminergic pathways in mammals have been described in previous studies [25,26]. In the current study, we therefore focused on the BPA effects on dopaminergic pathways in fish.…”

Section: Expression Profiles Of Genes In Dopaminergic Signaling Pathwmentioning

confidence: 94%

“…BPA also affects various biological processes in fish, including metabolism, individual cortisol stress responses, energy metabolism, muscle structure, motor behavior, and axonal growth, thereby affecting fish growth and development [21][22][23][24]. In mammals, studies have shown that BPA is neurotoxic and induces brain, region-specific changes in dopaminergic processes, resulting in hyperactivity and attention deficits [25,26]. While numerous toxicological studies have described the effects of BPA on fish, few have investigated the effects of BPA on fish brain.…”

Section: Introductionmentioning

confidence: 99%

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Assessment of the Effects of Bisphenol A on Dopamine Synthesis and Blood Vessels in the Goldfish Brain

Wang

Lin

et al. 2019

IJMS

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Bisphenol A (BPA) is an abundant contaminant found in aquatic environments. While a large number of toxicological studies have investigated the effects of BPA, the potential effects of BPA exposure on fish brain have rarely been studied. To understand how BPA impacts goldfish brains, we performed a transcriptome analysis of goldfish brains that had been exposed to 50 μg L−1 and 0 μg L−1 BPA for 30 days. In the analysis of unigene expression profiles, 327 unigenes were found to be upregulated and 153 unigenes were found to be downregulated in the BPA exposure group compared to the control group. Dopaminergic signaling pathway-related genes were significantly downregulated in the BPA exposure group. Furthermore, we found that serum dopamine concentrations decreased and TUNEL (terminal deoxynucleotidyl transferase 2-deoxyuridine, 5-triphosphate nick end labeling) staining was present in dopamine neurons enriched regions in the brain after BPA exposure, suggesting that BPA may disrupt dopaminergic processes. A KEGG analysis revealed that genes involved in the fluid shear stress and atherosclerosis pathway were highly significantly enriched. In addition, the qRT-PCR results for fluid shear stress and atherosclerosis pathway-related genes and the vascular histology of the brain showed that BPA exposure could damage blood vessels and induce brain atherosclerosis. The results of this work provide insights into the biological effects of BPA on dopamine synthesis and blood vessels in goldfish brain and could lay a foundation for future BPA neurotoxicity studies.

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Section: Analysis Of Dopamine Concentrations and Brain Dopaminergic Nsupporting

confidence: 64%

Section: Analysis Of Dopamine Concentrations and Brain Dopaminergic Nmentioning

confidence: 86%

Section: Expression Profiles Of Genes In Dopaminergic Signaling Pathwmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

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Assessment of the Effects of Bisphenol A on Dopamine Synthesis and Blood Vessels in the Goldfish Brain

Wang

Lin

et al. 2019

IJMS

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“…Takeuchi et al (2017) review matingrelated behaviors in the medaka fish, namely female mating preference and male mate-guarding behavior, and their control by neuropeptide neuromodulatory systems. Matsui (2017) reviews the structure and function of the dopamine system, cerebellum and nucleus ruber, commonly shared in the teleost and human brains. Hibi et al (2017) review and discuss evolutionary mechanisms that generate the structure and neural circuit diversity of the vertebrate cerebellum.…”

mentioning

confidence: 99%

Preface to Vertebrate Brains: evolution, structures and functions

Kikuchi

Murakami

2017

Dev Growth Differ

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How do zebrafish (Danio rerio) respond to MK‐801 and amphetamine? Relevance for assessing schizophrenia‐related endophenotypes in alternative model organisms

Benvenutti

Gallas‐Lopes

Sachett

et al. 2021

J of Neuroscience Research

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Schizophrenia pathophysiology has been associated with dopaminergic hyperactivity, NMDA receptor hypofunction, and redox dysregulation. Most behavioral assays and animal models to study this condition were developed in rodents, leaving room for species‐specific biases that could be avoided by cross‐species approaches. As MK‐801 and amphetamine are largely used in mice and rats to mimic schizophrenia features, this study aimed to compare the effects of these drugs in several zebrafish (Danio rerio) behavioral assays. Male and female adult zebrafish were exposed to MK‐801 (1, 5, and 10 μM) or amphetamine (0.625, 2.5, and 10 mg/L) and observed in paradigms of locomotor activity and social behavior. Oxidative parameters were quantified in brain tissue. Our results demonstrate that MK‐801 disrupted social interaction, an effect that resembles the negative symptoms of schizophrenia. It also altered locomotion in a context‐dependent manner, with hyperactivity when fish were tested in the presence of social cues and hypoactivity when tested alone. On the other hand, exposure to amphetamine was devoid of effects on locomotion and social behavior, while it increased lipid peroxidation in the brain. Key outcomes induced by MK‐801 in rodents, such as social interaction deficit and locomotor alterations, were replicated in zebrafish, corroborating previous studies and reinforcing the use of zebrafish to study schizophrenia‐related endophenotypes. More studies are necessary to assess the predictive validity of preclinical paradigms with this species and ultimately optimize the screening of potential novel treatments.

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Dopamine system, cerebellum, and nucleus ruber in fish and mammals

Cited by 27 publications

References 118 publications

Assessment of the Effects of Bisphenol A on Dopamine Synthesis and Blood Vessels in the Goldfish Brain

Assessment of the Effects of Bisphenol A on Dopamine Synthesis and Blood Vessels in the Goldfish Brain

Preface to Vertebrate Brains: evolution, structures and functions

How do zebrafish (Danio rerio) respond to MK‐801 and amphetamine? Relevance for assessing schizophrenia‐related endophenotypes in alternative model organisms

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