Dopamine Signaling in the Bee

Mustard, Julie A.; Vergoz, Vanina; Mesce, Karen A.; Klukas, Kathleen A.; Beggs, Kyle T.; Geddes, Lisa H.; McQuillan, H James; Mercer, Alison R.

doi:10.1007/978-94-007-2099-2_16

Cited by 14 publications

(14 citation statements)

References 49 publications

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“…JH is thought to stimulate uptake of vitellogenin (yolk protein) by the ovaries in solitary insects, but JH has apparently lost this function in adult reproductives of honey bees (Robinson and Vargo, 1997) and some ants (Brent et al, 2006;Sommer et al, 1993). Instead, there is increasing evidence in Apis mellifera that dopamine serves as a gonadotropin (Brandes et al, 1990;Harris and Woodring, 1995;Mustard et al, 2012;Vergoz et al, 2012), and our results suggest this could be true for other social insects, including ants. Dominance in some social insect species has been associated with elevated octopamine (Bloch et al, 2000c;Cuvillier-Hot and Lenoir, 2006), but octopamine levels in gamergates of H. saltator did not differ from those of non-reproductive workers.…”

Section: Discussionmentioning

confidence: 64%

“…Harpegnathos saltator has three dopamine receptor genes (Hsaldop1,, which are orthologs of dopamine receptor genes found in honey bees and Drosophila melanogaster (Bonasio et al, 2010) and may have similarities to dopamine receptor genes in vertebrate species (Mustard et al, 2012). All three dopamine receptor genes were expressed in brains of gamergates and workers (N=10 colonies), but only the receptor genes for Hsaldop1 and Hsal-dop3 were consistently expressed in the ovaries at quantifiable levels (Fig.…”

Section: Expression Of Dopamine Receptor Genes In Brains and Ovariesmentioning

confidence: 93%

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Neurohormonal changes associated with ritualized combat and the formation of a reproductive hierarchy in the antHarpegnathos saltator

Penick

Brent

Dolezal

et al. 2014

Journal of Experimental Biology

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Dominance rank in animal societies is correlated with changes in both reproductive physiology and behavior. In some social insects, dominance status is used to determine a reproductive division of labor, where a few colony members reproduce while most remain functionally sterile. Changes in reproduction and behavior in this context must be coordinated through crosstalk between the brain and the reproductive system. We investigated a role for biogenic amines in forming this connection in the ant Harpegnathos saltator. In this species, workers engage in an elaborate dominance tournament to establish a group of reproductive workers termed gamergates. We analyzed biogenic amine content in the brains of gamergates, insideworkers and foragers under stable colony conditions and found that gamergates had the highest levels of dopamine. Dopamine levels were also positively correlated with increased ovarian activity among gamergates. Next, we experimentally induced workers to compete in a reproductive tournament to determine how dopamine may be involved in the establishment of a new hierarchy. Dopamine levels rose in aggressive workers at the start of a tournament, while workers that were policed by their nestmates (a behavior that inhibits ovarian activity) showed a rapid decline in dopamine. In addition to dopamine, levels of serotonin and tyramine differed among castes, and these changes could contribute to differences in caste-specific behavioral patterns observed among non-reproductive workers. Overall, these results provide support that biogenic amines link changes in behavior and dominance with reproductive activity in H. saltator as well as drive differences in worker task performance.

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Section: Discussionmentioning

confidence: 64%

Section: Expression Of Dopamine Receptor Genes In Brains and Ovariesmentioning

confidence: 93%

Neurohormonal changes associated with ritualized combat and the formation of a reproductive hierarchy in the antHarpegnathos saltator

Penick

Brent

Dolezal

et al. 2014

Journal of Experimental Biology

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“…In Schistocerca , cAMP-dependent protein kinases (PKA) is critical in the acquisition of the gregarious behavior (Ott et al, 2012 ). Besides linking with 5-HT signaling in mediating the crowding of Schistocerca (Ott et al, 2012 ), PKA is also involved in DA signaling (Romanelli et al, 2010 ; Mustard et al, 2012 ). Thus, the higher level of cAMP-PKA may be related to the gregarization in the two locust species.…”

Section: Discussionmentioning

confidence: 99%

“…DA modulates diverse behaviors in vertebrates and invertebrates through varied receptors in specific regions of the central nervous system (Romanelli et al, 2010 ; Mustard et al, 2012 ). In vertebrates, five dopamine receptor subtypes have been identified; these subtypes have been further classified into two major groups, namely, D1-like (D1 and D5) and D2-like (D2, D3, and D4) receptors (Romanelli et al, 2010 ).…”

Section: Introductionmentioning

confidence: 99%

Two dopamine receptors play different roles in phase change of the migratory locust

Guo

Kang

2015

Front. Behav. Neurosci.

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The migratory locust, Locusta migratoria, shows remarkable phenotypic plasticity at behavioral, physiological, and morphological levels in response to fluctuation in population density. Our previous studies demonstrated that dopamine (DA) and the genes in the dopamine metabolic pathway mediate phase change in Locusta. However, the functions of different dopamine receptors in modulating locust phase change have not been fully explored. In the present study, DA concentration in the brain increased during crowding and decreased during isolation. The expression level of dopamine receptor 1 (Dop1) increased from 1 to 4 h of crowding, but remained unchanged during isolation. Injection of Dop1 agonist SKF38393 into the brains of solitary locusts promoted gregarization, induced conspecific attraction-response and increased locomotion. RNAi knockdown of Dop1 and injection of antagonist SCH23390 in gregarious locusts induced solitary behavior, promoted the shift to repulsion-response and reduced locomotion. By contrast, the expression level of dopamine receptor 2 (Dop2) gradually increased during isolation, but remained stable during crowding. During the isolation of gregarious locusts, injection of Dop2 antagonist S(–)-sulpiride or RNAi knockdown of Dop2 inhibited solitarization, maintained conspecific attraction-response and increased locomotion; by comparison, the isolated controls displayed conspecific repulsion-response and weaker motility. Activation of Dop2 in solitary locusts through injection of agonist, R(-)-TNPA, did not affect their behavioral state. Thus, DA-Dop1 signaling in the brain of Locusta induced the gregariousness, whereas DA-Dop2 signaling mediated the solitariness. Our study demonstrated that Dop1 and Dop2 modulated locust phase change in two different directions. Further investigation of Locusta Dop1 and Dop2 functions in modulating phase change will improve our understanding of the molecular mechanism underlying phenotypic plasticity in locusts.

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“…The honeybee is an important model organism for unraveling neuronal mechanisms underlying behavioral phenomena like division of labor, learning, and memory (Galizia, Eisenhardt, & Giurfa, ). Many examples show that honeybee behavior is either under control or under modulation of biogenic amines (for reviews see: Blenau, Thamm, & Baumann, ; Mustard et al, ; Roeder, ; Scheiner, Baumann, & Blenau, ). These are important neuroactive compounds which can act as neurotransmitters, neuromodulators, or neurohormones (Blenau & Baumann, ; Evans, ; Roeder, ).…”

Section: Introductionmentioning

confidence: 99%

Neuronal distribution of tyramine and the tyramine receptor AmTAR1 in the honeybee brain

Thamm

Scholl

Reim

et al. 2017

J of Comparative Neurology

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Tyramine is an important neurotransmitter, neuromodulator, and neurohormone in insects. In honeybees, it is assumed to have functions in modulating sensory responsiveness and controlling motor behavior. Tyramine can bind to two characterized receptors in honeybees, both of which are coupled to intracellular cAMP pathways. How tyramine acts on neuronal, cellular and circuit levels is unclear. We investigated the spatial brain expression of the tyramine receptor AmTAR1 using a specific antibody. This antibody detects a membrane protein of the expected molecular weight in western blot analysis. In honeybee brains, it labels different structures which process sensory information. Labeling along the antennal nerve, in projections of the dorsal lobe and in the gnathal ganglion suggest that tyramine receptors are involved in modulating gustatory and tactile perception. Furthermore, the ellipsoid body of the central complex and giant synapses in the lateral complex show AmTAR1-like immunoreactivity (AmTAR1-IR), suggesting a role of this receptor in modulating sky-compass information and/or higher sensor-motor control. Additionally, intense signals derive from the mushroom bodies, higher-order integration centers for olfactory, visual, gustatory and tactile information. To investigate whether AmTAR1-expressing brain structures are in vicinity to tyramine releasing sites, a specific tyramine antibody was applied. Tyramine-like labeling was observed in AmTAR1-IR positive structures, although it was sometimes weak and we did not always find a direct match of ligand and receptor. Moreover, tyramine-like immunoreactivity was also found in brain regions without AmTAR1-IR (optic lobes, antennal lobes), indicating that other tyramine-specific receptors may be expressed there.

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Dopamine Signaling in the Bee

Cited by 14 publications

References 49 publications

Neurohormonal changes associated with ritualized combat and the formation of a reproductive hierarchy in the antHarpegnathos saltator

Neurohormonal changes associated with ritualized combat and the formation of a reproductive hierarchy in the antHarpegnathos saltator

Two dopamine receptors play different roles in phase change of the migratory locust

Neuronal distribution of tyramine and the tyramine receptor AmTAR1 in the honeybee brain

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