Dopamine-secreting Carotid Body Paragangliomas-Biochemical Control with Radiotherapy

Soh, Abel Wah Ek; Kek, Peng Chin

doi:10.2169/internalmedicine.51.6324

Cited by 11 publications

(10 citation statements)

References 41 publications

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“…3) The management of head and neck paragangliomas include surgical resection, external beam radiotherapy, and stereotactic radiotherapy. 23,24) Small lesions may be successfully removed with little risk to the patient. However, if resection of the carotid vessels is anticipated or if a large lesion is fixed or unresectable because of size, radiotherapy is the preferred initial treatment.…”

Section: Resultsmentioning

confidence: 99%

Carotid Body Tumors: A Review of 25 Years Experience in Diagnosis and Management of 56 Tumors

Gad

Sayed

Elwan

et al. 2014

Annals of Vascular Diseases

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Section: Resultsmentioning

confidence: 99%

Carotid Body Tumors: A Review of 25 Years Experience in Diagnosis and Management of 56 Tumors

Gad

Sayed

Elwan

et al. 2014

Annals of Vascular Diseases

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“…Radiation and chemotherapy therapies proposed by individual authors can only be recommended to patients who have contraindications to surgery from other systems of the body [14].…”

Section: Discussionmentioning

confidence: 99%

Experience of Surgical Treatment of the Carotid Body Tumor and Tumors With Invasion at the Carotid Vessels

Kobza

Savchenko

2017

Technology transfer: innovative solutions in medicine

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The analysis of the structure and results of surgical treatment of 72 patients who were hospitalized in the department of vascular surgery Lviv regional hospital for the period 1995 to 2017. Among the 42 cases was diagnosed carotid body tumors (1-st study group) and at 30 patients was (2-nd control group) other tumors of the neck. In first group structure of surgery operation was: tumor removal and suturing the vascular wall defects - 76%, resection and shortening of the common carotid artery - 21%, expansion of the internal carotid artery - 3%, ligation of the external carotid artery - 10%, lymphadenectomy - 28%, prosthetic vascular wall - 3%, the tumor resection - 3%, internal jugular vein ligation - 7%, excision of fragment muscle - 3%, nerve resection - 14%. In the second group, the following surgical operations were performed: removal of the tumor and suturing of the defects of the vascular wall - 96%, lymphadenectomy - 48% tumor resection - 30%, ligation of the internal jugular vein - 14%, removal of the muscle fragment - 4% , resection of nerves - 13%. In group 1, intraoperative complications were observed in 1 (3.4%) cases, which were manifested by massive bleeding from the tumor, requiring a repeated surgical intervention to stop the bleeding. Postoperative complications were observed in 1 (3.4%) cases when acute cerebral ischemia developed. In 1 (3.4%) cases, tumor recurrence was observed after 9 years. Clinic experience shows that surgery is an effective treatment for carotid body tumor and tumors with invasion into vessels of the neck, providing a low rate of complications, a full recovery or long-term remission

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“…41 As well as the secretion of catecholamines, five cases have been described in the literature that exclusively secreted dopamine, all of which were associated with bilateral CPGs and/or malignancy. 42 Our experience is limited to a single PG case in the organ of Zuckerkandl, which was satisfactorily controlled/treated with the aforementioned preoperative and intraoperative measures. 9 4.5 | Reoperation on recurrent (relapsing) and residual (persistent) tumors…”

Section: Resection Of a Functional Cpgmentioning

confidence: 99%

Simple and complex carotid paragangliomas. Three decades of experience and literature review

et al. 2020

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Background: Carotid paragangliomas are rare tumors. They are usually unique, non-secreting, resectable, and benign. However, additional rare cases of complex tumors (bilateral, secretory, nonresectable, or malignant) complicate the management and final outcomes. Methods: Records of paragangliomas from our hospital are reviewed. Criteria defining complex paragangliomas have been previously defined. These are compared with those of the simple group. Results: Fifty patients, two groups: simple (n = 39) and complex (n = 11). The patients in the complex group were significantly younger (47.7 vs 63.8 years). Postoperative nerve complications (45.4% vs 6.3%) and mortality during follow-up (27.3% vs 0%) were significantly more common in the complex group. Vascular complications (0% vs 3.1%) and early mortality (0%) were similarly in both groups. Conclusions: Patients with complex carotid paragangliomas are heterogeneous. The former are younger, exhibit a high degree of diagnostic and therapeutic complexity, and have poorer morbidity and mortality. Surgical experience and interdisciplinary collaboration are essential.

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Dopamine-secreting Carotid Body Paragangliomas-Biochemical Control with Radiotherapy

Cited by 11 publications

References 41 publications

Carotid Body Tumors: A Review of 25 Years Experience in Diagnosis and Management of 56 Tumors

Carotid Body Tumors: A Review of 25 Years Experience in Diagnosis and Management of 56 Tumors

Experience of Surgical Treatment of the Carotid Body Tumor and Tumors With Invasion at the Carotid Vessels

Simple and complex carotid paragangliomas. Three decades of experience and literature review

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