Dopamine Replacement Therapy and Deep Brain Stimulation of the Subthalamic Nuclei Induce Modulation of Emotional Processes at Different Spatial Frequencies in Parkinson's Disease

Mermillod, Martial; Mondillon, Laurie; Rieu, Isabelle; Devaux, Damien; Chambres, Patrick; Auxiette, Catherine; H, Dalens; Coulangeon, L.-M.; Jalenques, Isabelle; Durif, Franck

doi:10.3233/jpd-130256

Cited by 9 publications

(13 citation statements)

References 53 publications

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“…Regarding the methodology of studies conducted so far, patients were tested in alternating experimental settings with stimulation ON or OFF and medication on or off, i.e., DBS ON/med on, DBS ON/med off, DBS OFF/med on, and DBS OFF/med off. Studies have either compared the pre- to postoperative condition after STN DBS within the same PD group [ 40 – 42 , 63 , 64 ], matched PD groups [ 44 , 48 , 49 ], or PD patients with matched HC [ 46 , 48 , 62 , 65 ]. Most studies reported impaired FER after STN DBS compared to before surgery [ 40 – 44 ].…”

Section: Resultsmentioning

confidence: 99%

Effects of Subthalamic Nucleus Deep Brain Stimulation on Facial Emotion Recognition in Parkinson’s Disease: A Critical Literature Review

Kalampokini

Lyros

Lochner

et al. 2020

Behavioural Neurology

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Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an effective therapy for Parkinson’s disease (PD). Nevertheless, DBS has been associated with certain nonmotor, neuropsychiatric effects such as worsening of emotion recognition from facial expressions. In order to investigate facial emotion recognition (FER) after STN DBS, we conducted a literature search of the electronic databases MEDLINE and Web of science. In this review, we analyze studies assessing FER after STN DBS in PD patients and summarize the current knowledge of the effects of STN DBS on FER. The majority of studies, which had clinical and methodological heterogeneity, showed that FER is worsening after STN DBS in PD patients, particularly for negative emotions (sadness, fear, anger, and tendency for disgust). FER worsening after STN DBS can be attributed to the functional role of the STN in limbic circuits and the interference of STN stimulation with neural networks involved in FER, including the connections of the STN with the limbic part of the basal ganglia and pre- and frontal areas. These outcomes improve our understanding of the role of the STN in the integration of motor, cognitive, and emotional aspects of behaviour in the growing field of affective neuroscience. Further studies using standardized neuropsychological measures of FER assessment and including larger cohorts are needed, in order to draw definite conclusions about the effect of STN DBS on emotional recognition and its impact on patients’ quality of life.

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Section: Resultsmentioning

confidence: 99%

Effects of Subthalamic Nucleus Deep Brain Stimulation on Facial Emotion Recognition in Parkinson’s Disease: A Critical Literature Review

Kalampokini

Lyros

Lochner

et al. 2020

Behavioural Neurology

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“…In contrast to healthy subjects, Parkinson's disease patients responded more slowly and less accurately in the emotional trials than in the control trials, suggesting specific difficulties in processing emotional information. Indeed, faces expressing fear (i.e., negative emotions) were recognized more slowly disturbance has been shown to improve with the combination of STN DBS and levodopa, with this effect being related to the modulation of occipito-temporal activity (Mermillod et al, 2014), which are the regions where we found the highest modulation (N170 source generators shown that Emotional Stroops can be sensitive to the so-called "emotional dilution phenomenon" (Chajut, Schupak, & Algom, 2010;Reynolds & Langerak, 2015), where subject's impaired processing of the emotion decreases the conflict-based difference between congruent and incongruent trials. Thus, by improving emotion recognition and disengagement from the emotion of the face, levodopa would increase susceptibility to both the face and the word, reducing emotional dilution, and thus increasing conflict detection.…”

Section: Emotional Processing Disturbances In Parkinson's Disease Pmentioning

confidence: 99%

Different effects of levodopa and subthalamic stimulation on emotional conflict in Parkinson's disease

Martínez‐Fernández

Kibleur

Chabardès

et al. 2018

Human Brain Mapping

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Parkinson's disease impairs the decoding of emotional stimuli reflecting alterations of the limbic cortico‐subcortical network. The objective of this study was to assess and compare the behavioral and electrophysiological effects of both levodopa and subthalamic stimulation on emotional processing in Parkinson's disease. Operated patients (n =16) and matched healthy subjects performed an emotional Stroop task, in which the emotion expressed by a face must be recognized while ignoring an emotional distractive word and that includes a neutral control sub‐task. Patients were tested in the four possible treatment conditions (off stim/off med; on stim/off med; off stim/on med; and on stim/on med). High‐resolution electroencephalography was recorded while performing the task. Patients made significantly more mistakes in facial emotion recognition than healthy subjects (p < .005). Untreated patients performed worse in the emotional trials than in the control sub‐task (p < .05). Fearful faces induced significantly slower reaction times than happy faces in patients (p = .0002), but not in the healthy subjects. The emotional Stroop effect with levodopa was significantly higher than with subthalamic stimulation when fearful faces were assessed (p = .0243). Conversely, treatments did not modulate the Stroop effect of the control sub‐task. EEG demonstrated that, compared with the untreated state, levodopa but not subthalamic stimulation significantly increases the amplitude of the event‐related potential N170 (p = .002 vs. p = .1, respectively), an electrophysiological biomarker of early aspects of facial processing. The activity of the N170 cortical sources within the right fusiform gyrus was increased by levodopa (p < .05) but not by stimulation. While levodopa normalizes the recognition of emotional facial expression and early EEG markers of emotional processing, subthalamic stimulation does not. Thus, operated patients require dopaminergic medication in addition to stimulation to treat emotional symptoms of Parkinson's disease.

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“…In addition to no differences in magnitude across groups, the magnitude of the EAB was unaffected by therapeutic DBS. Several reports suggest STN-DBS can affect emotional processing, such as emotional face recognition [ 10 , 18 , 19 ]. This dissociation between deficits in explicit fear recognition shown previously and intact performance in more implicit tasks such as the EAB shown in the present study suggest that the course of the disease and therapeutic condition may differentially affect some emotional processing paths.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Deep Brain Stimulation Therapy on Fear-Related Capture of Attention in Parkinson' s Disease and Essential Tremor: A Comparison to Healthy Individuals

2018

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In addition to motor symptoms, Parkinson’s disease (PD) involves significant non-motor sequelae, including disruptions in cognitive and emotional processing. Fear recognition appears to be affected both by the course of the disease and by a common interventional therapy, deep brain stimulation of the subthalamic nucleus (STN-DBS). Here, we examined if these effects extend to other aspects of emotional processing, such as attentional capture by negative emotional stimuli. Performance on an emotional attentional blink (EAB) paradigm, a common paradigm used to study emotional capture of attention, was examined in a cohort of individuals with PD, both on and off STN-DBS therapy (n=20). To contrast effects of healthy aging and other movement disorder and DBS targets, we also examined performance in a healthy elderly (n=20) and young (n=18) sample on the same task, and a sample diagnosed with Essential Tremor (ET) undergoing therapeutic deep brain stimulation of the ventral-intermediate nucleus (VIM-DBS, n=18). All four groups showed a robust attentional capture of emotional stimuli, irrespective of aging processes, movement disorder diagnosis, or stimulation. PD patients on average had overall worse performance, but this decrement in performance was not related to the emotional capture of attention. PD patients exhibited a robust EAB, indicating that the ability of emotion to direct attention remains intact in PD. Congruent with other recent data, these findings suggest that fear recognition deficits in PD may instead reflect a highly specific problem in recognition, rather than a general deficit in emotional processing of fearful stimuli.

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Dopamine Replacement Therapy and Deep Brain Stimulation of the Subthalamic Nuclei Induce Modulation of Emotional Processes at Different Spatial Frequencies in Parkinson's Disease

Cited by 9 publications

References 53 publications

Effects of Subthalamic Nucleus Deep Brain Stimulation on Facial Emotion Recognition in Parkinson’s Disease: A Critical Literature Review

Effects of Subthalamic Nucleus Deep Brain Stimulation on Facial Emotion Recognition in Parkinson’s Disease: A Critical Literature Review

Different effects of levodopa and subthalamic stimulation on emotional conflict in Parkinson's disease

The Effect of Deep Brain Stimulation Therapy on Fear-Related Capture of Attention in Parkinson' s Disease and Essential Tremor: A Comparison to Healthy Individuals

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