Dopamine replacement improves motor learning of an upper extremity task in people with Parkinson disease

Paul, Serene S.; Dibble, Leland E.; Olivier, Geneviève N.; Walter, Christopher S.; Duff, Kevin; Schaefer, Sydney Y.

doi:10.1016/j.bbr.2019.112213

Cited by 21 publications

(30 citation statements)

References 45 publications

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“…Our laboratory has developed a quick, easy‐to‐administer motor task that objectively evaluates upper extremity dexterity and coordination. This task has been validated against other established upper extremity tasks 28 and is feasible for a wide range of ages and health conditions 29–32 . To summarize, participants are required to use a standard plastic spoon with their non‐dominant hand to acquire two raw kidney beans at a time from a central cup to one of three distal cups arranged at a radius of 16 cm at −40°, 0° and 40° relative to the central cup, starting with the cup ipsilateral to their non‐dominant hand, then to the middle cup, then the contralateral cup.…”

Section: Methodsmentioning

confidence: 99%

Challenging the relationship of grip strength with cognitive status in older adults

Hooyman

Malek‐Ahmadi

Fauth

et al. 2020

Int J Geriat Psychiatry

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Objective Grip strength is a widely used motor assessment in ageing research and has repeatedly been shown to be associated with cognition. It has been proposed that grip strength could enhance cognitive screening in experimental or clinical research, but this study uses multiple data‐driven approaches to caution against this interpretation. Furthermore, we introduce an alternative motor assessment, comparable to grip dynamometry, but has a more robust relationship with cognition among older adults. Design Associations between grip strength and cognition (measured with the Montreal Cognitive Assessment) were analysed cross sectionally using multivariate regression in two datasets: (1) The Irish LongituDinal Study on Ageing (TILDA; N = 5,980, community‐dwelling adults ages 49–80) and (2) an experimental dataset (N = 250, community‐dwelling adults aged 39–98). Additional statistical simulations on TILDA tested how ceiling effects or skewness in these variables influenced these associations for quality control. Results Grip strength was significantly but weakly associated with cognition, consistent with previous studies. Simulations revealed this was not due to skewness/ceiling effects. Conversely, a new alternative motor assessment (functional reaching [FR]) had a stronger, more robust and more sensitive relationship with cognition compared to grip strength. Conclusions Grip strength should be cautiously interpreted as being associated with cognition. However, FR may have a stronger and clinically useful relationship with cognition.

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Section: Methodsmentioning

confidence: 99%

Challenging the relationship of grip strength with cognitive status in older adults

Hooyman

Malek‐Ahmadi

Fauth

et al. 2020

Int J Geriat Psychiatry

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“…For example, injection of DA into the nucleus accumbens restored normal motor activity in rats with reduced motor activity from the injection of 6-hhyroxydopamine causing an 83% DA depletion (15). The loss of dopaminergic neurons and subsequent depletion of DA in the substantia nigra are known to cause the motor deficits observed in Parkinson's disease in both humans and rodent models (16)(17)(18). Dopamine D1 and D2 receptors in the hippocampus and amygdala are associated with anxiety-related behaviors.…”

Section: Introductionmentioning

confidence: 99%

High-Fat Diet-Induced Weight Gain, Behavioral Deficits, and Dopamine Changes in Young C57BL/6J Mice

et al. 2021

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Chronic exposure to a high-fat diet (HFD) may predispose individuals to neuropathologies and behavioral deficits. The objective of this study was to determine the temporal effects of a HFD on weight gain, behavioral deficits, and dopamine changes in young mice. One-month old C57BL/6J male and female mice were fed either a control diet (containing 10% calories from fat) or a HFD (containing 45% of calories from fat) for 5 months. Physiological measures such as food consumption, body weight, blood glucose, and behaviors such as motor activity, sensorimotor integration, and anxiety-like behaviors were evaluated monthly. Dopamine (DA), dopamine receptor D2 (DRD2), and dopamine transporter (DT) protein expression levels were measured in the midbrain after 5 months of dietary exposure. Results showed that body weight was significantly greater in the HFD-exposed group compared to the control-group at the end of the 4th month, while food consumption was similar in both groups. For behavioral effects, the HFD group exhibited a significant decrease in motor activity in the open field test after 3 months, and rearing frequency after 4 months of dietary exposure. The HFD group also showed deficits in sensorimotor integration after 3 months. Specifically, chronic HFD exposure increased contact time and time to remove the first adhesive tape in the adhesive-tape removal test (p < 0.05). Furthermore, the HFD group showed significant deficits in balance/coordination compared to the control group after 4 months of dietary exposure using the beam traverse test, and increased anxiety-like behavior tested by both the open field and light/dark box tests (p < 0.05). Neurochemical measurements showed that HFD-exposed mice had significantly higher midbrain DA and DRD2 protein levels compared to the control group after 5 months of dietary exposure (p < 0.05). These results indicate that the impact of HFD on the C57BL/6J mouse strain began at the 3rd month of dietary exposure. Behavioral deficits occurred at a similar time point as increased body weight, at about 3–4 months. Overall, this study provides a critical understanding on how HFD-induced changes in weight gain and behavioral deficits in this strain occur over time. The behavioral changes support the idea that changes also occurred in neurochemical pathways such as dopamine dysregulation.

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“…Although the clinical strategies of alleviating DA-related symptoms in PD by DAergic replacement have been proved highly successful in treating the motor symptoms (233), the effects on motor learning ability remained controversial probably due to different motor tasks being used. One clinical trial on the effect of L-dopa on patients with mild-moderate PD showed improved learning of upper extremity task (234). Another two clinical trials suggested that the L-dopa medication did not significantly alter learning performance of the stepping task in PD patients (235,236).…”

Section: Daergic Enhancementmentioning

confidence: 99%

Neurotransmitters, Cell Types, and Circuit Mechanisms of Motor Skill Learning and Clinical Applications

Tian

Chen

2021

Front. Neurol.

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Animals acquire motor skills to better survive and adapt to a changing environment. The ability to learn novel motor actions without disturbing learned ones is essential to maintaining a broad motor repertoire. During motor learning, the brain makes a series of adjustments to build novel sensory–motor relationships that are stored within specific circuits for long-term retention. The neural mechanism of learning novel motor actions and transforming them into long-term memory still remains unclear. Here we review the latest findings with regard to the contributions of various brain subregions, cell types, and neurotransmitters to motor learning. Aiming to seek therapeutic strategies to restore the motor memory in relative neurodegenerative disorders, we also briefly describe the common experimental tests and manipulations for motor memory in rodents.

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Dopamine replacement improves motor learning of an upper extremity task in people with Parkinson disease

Cited by 21 publications

References 45 publications

Challenging the relationship of grip strength with cognitive status in older adults

Challenging the relationship of grip strength with cognitive status in older adults

High-Fat Diet-Induced Weight Gain, Behavioral Deficits, and Dopamine Changes in Young C57BL/6J Mice

Neurotransmitters, Cell Types, and Circuit Mechanisms of Motor Skill Learning and Clinical Applications

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