Dopamine regulation of human speech and bird song: A critical review

Simonyan, Kristina; Horwitz, Barry; Jarvis, Erich D.

doi:10.1016/j.bandl.2011.12.009

Cited by 72 publications

(62 citation statements)

References 123 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…We use songbirds as recoding model because their auditory area is similar to Superior Gyro area of the human brain which deals with speech and acoustic, making it a good candidate for neural recording [14]. Preliminary recording from GC microelectrode arrays has shown that the GC microelectrode array is capable of simultaneously record high quality single-unit neural activity at four different depth locations (220μm vertical spacing).…”

Section: Resultsmentioning

confidence: 99%

In Vivo Dopamine Detection and Single Unit Recordings Using Intracortical Glassy Carbon Microelectrode Arrays

et al. 2018

View full text Add to dashboard Cite

In this study, we present a 4-channel intracortical glassy carbon (GC) microelectrode array on a flexible substrate for the simultaneous in vivo neural activity recording and dopamine (DA) concentration measurement at four different brain locations (220μm vertical spacing). The ability of GC microelectrodes to detect DA was firstly assessed in vitro in phosphate-buffered saline solution and then validated in vivo measuring spontaneous DA concentration in the Striatum of European Starling songbird through fast scan cyclic voltammetry (FSCV). The capability of GC microelectrode arrays and commercial penetrating metal microelectrode arrays to record neural activity from the Caudomedial Neostriatum of European starling songbird was compared. Preliminary results demonstrated the ability of GC microelectrodes in detecting neurotransmitters release and recording neural activity in vivo. GC microelectrodes array may, therefore, offer a new opportunity to understand the intimate relations linking electrophysiological parameters with neurotransmitters release.

show abstract

Section: Resultsmentioning

confidence: 99%

In Vivo Dopamine Detection and Single Unit Recordings Using Intracortical Glassy Carbon Microelectrode Arrays

et al. 2018

View full text Add to dashboard Cite

show abstract

“…Four categories of behavior (vocalization, gaze, affect, and touch) were coded for each dyadic partner, and then the temporal synchronization of those behaviors was computed. We chose to operationalize synchrony using behavioral contingencies of vocalization because vocalization is an outgoing appetitive behavior central to bonding (10,32), which relates to dopamine (33), and can be measured accurately in both mothers and infants (1).…”

Section: Methodsmentioning

confidence: 99%

Dopamine in the medial amygdala network mediates human bonding

Atzil

Touroutoglou

Rudy

et al. 2017

Proc. Natl. Acad. Sci. U.S.A.

113

View full text Add to dashboard Cite

Research in humans and nonhuman animals indicates that social affiliation, and particularly maternal bonding, depends on reward circuitry. Although numerous mechanistic studies in rodents demonstrated that maternal bonding depends on striatal dopamine transmission, the neurochemistry supporting maternal behavior in humans has not been described so far. In this study, we tested the role of central dopamine in human bonding. We applied a combined functional MRI-PET scanner to simultaneously probe mothers' dopamine responses to their infants and the connectivity between the nucleus accumbens (NAcc), the amygdala, and the medial prefrontal cortex (mPFC), which form an intrinsic network (referred to as the "medial amygdala network") that supports social functioning. We also measured the mothers' behavioral synchrony with their infants and plasma oxytocin. The results of this study suggest that synchronous maternal behavior is associated with increased dopamine responses to the mother's infant and stronger intrinsic connectivity within the medial amygdala network. Moreover, stronger network connectivity is associated with increased dopamine responses within the network and decreased plasma oxytocin. Together, these data indicate that dopamine is involved in human bonding. Compared with other mammals, humans have an unusually complex social life. The complexity of human bonding cannot be fully captured in nonhuman animal models, particularly in pathological bonding, such as that in autistic spectrum disorder or postpartum depression. Thus, investigations of the neurochemistry of social bonding in humans, for which this study provides initial evidence, are warranted.arly social bonding with a primary caregiver is necessary for mental and physical health, whereas the absence of such bonding is a clear risk factor for adult illness (1). However, despite potentially enormous implications, to date the science of mother-infant bonding relies mostly on nonhuman animal models.Research on nonhuman animals indicates that maternal bonding involves the nucleus accumbens (NAcc), amygdala, and medial prefrontal cortex (mPFC). In rodents, oxytocin and dopamine act in the amygdala and NAcc (2) to regulate maternal appetitive behaviors. In humans, functional MRI (fMRI) studies have verified that NAcc activity increases consistently when mothers gaze at their infants (3). Moreover, the NAcc and amygdala activity have been linked to the quality of maternal behavior (4). Mothers who were sensitive to their infants' cues for social engagement and who adjusted their own behavior to meet those needs (referred to as "mother-infant synchrony"), showed greater activations in the left NAcc and lower activation in the right amygdala when viewing films of their infants than did nonsynchronous mothers (4). In agreement with the animal studies, oxytocin has been implicated in human maternal behavior, so that synchronous mothers show a stronger link between levels of circulating plasma oxytocin and NAcc fMRI activations when viewing films of their in...

show abstract

“…In regard to the central motor control, the open question is what (neurologically) makes us humans unique in our ability to learn and produce voice for speech and song as oppose to other primate species, which have limited, if any, capacity for vocal learning and voluntary voice production [1,2]••. A possible candidate brain region that appears to have grossly similar but importantly distinct topology and connectivity in humans compared to other mammals is the LMC itself.…”

Section: Introductionmentioning

confidence: 99%

The laryngeal motor cortex: its organization and connectivity

Simonyan

2014

Current Opinion in Neurobiology

Self Cite

152

119

View full text Add to dashboard Cite

Our ability to learn and control the motor aspects of complex laryngeal behaviors, such as speech and song, is modulated by the laryngeal motor cortex (LMC), which is situated in the area 4 of the primary motor cortex and establishes both direct and indirect connections with laryngeal motoneurons. In contrast, the LMC in monkeys is located in the area 6 of the premotor cortex, projects only indirectly to laryngeal motoneurons and its destruction has essentially no effect on production of species-specific calls. These differences in cytoarchitectonic location and connectivity may be a result of hominid evolution that led to the LMC shift from the phylogenetically “old” to “new” motor cortex in order to fulfill its paramount function, i.e., voluntary motor control of human speech and song production.

show abstract

Dopamine regulation of human speech and bird song: A critical review

Cited by 72 publications

References 123 publications

In Vivo Dopamine Detection and Single Unit Recordings Using Intracortical Glassy Carbon Microelectrode Arrays

In Vivo Dopamine Detection and Single Unit Recordings Using Intracortical Glassy Carbon Microelectrode Arrays

Dopamine in the medial amygdala network mediates human bonding

The laryngeal motor cortex: its organization and connectivity

Contact Info

Product

Resources

About