Dopamine receptors participate in acquisition and consolidation of latent learning of spatial information in zebrafish (Danio rerio)

Naderi, Mohammad; Jamwal, Ankur; Ferrari, Maud C. O.; Niyogi, Som; Chivers, Douglas P.

doi:10.1016/j.pnpbp.2016.01.002

Cited by 29 publications

(41 citation statements)

References 86 publications

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“…In their native environment, the dopamine reward system might allow damselfish to recognize a beneficial reef or location such as their territory, profitable food source, or location of receptive mates for reproduction and encode this information for future use. These results support recent studies demonstrating a modulatory influence of dopamine on associative learning [15] and latent learning [24] in zebrafish, and learning decision-making tasks in cleaner wrasses [2]. Our results demonstrate that under these experimental conditions damselfish can develop object recognition memory for at least a 10-min span after D 1 agonist treatment.…”

Section: Discussionsupporting

confidence: 92%

Dopamine D1 receptor activation leads to object recognition memory in a coral reef fish

2017

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Object recognition memory is the ability to identify previously seen objects and is an adaptive mechanism that increases survival for many species throughout the animal kingdom. Previously believed to be possessed by only the highest order mammals, it is now becoming clear that fish are also capable of this type of memory formation. Similar to the mammalian hippocampus, the dorsolateral pallium regulates distinct memory processes and is modulated by neurotransmitters such as dopamine. Caribbean bicolour damselfish () live in complex environments dominated by coral reef structures and thus likely possess many types of complex memory abilities including object recognition. This study used a novel object recognition test in which fish were first presented two identical objects, then after a retention interval of 10 min with no objects, the fish were presented with a novel object and one of the objects they had previously encountered in the first trial. We demonstrate that the dopamine D-receptor agonist (SKF 38393) induces the formation of object recognition memories in these fish. Thus, our results suggest that dopamine-receptor mediated enhancement of spatial memory formation in fish represents an evolutionarily conserved mechanism in vertebrates.

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Section: Discussionsupporting

confidence: 92%

Dopamine D1 receptor activation leads to object recognition memory in a coral reef fish

2017

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“…DA plays a significant role in cognition and motor movement, so disruptions in the normal ontogeny of the DA system during critical windows of CNS development are expected to alter behavior. Modulation of the DA system, for example, impacts ZF learning and memory, illustrated through the application of different agonists and antagonists . Apomorphine, a nonselective DA agonist, impairs acquisition and consolidation of latent learning in ZF, characterized by prolonged latency to leave the start chamber, increased dwelling time in incorrect tunnels, and latency in reaching reward chambers .…”

Section: Discussionmentioning

confidence: 99%

“…Modulation of the DA system, for example, impacts ZF learning and memory, illustrated through the application of different agonists and antagonists . Apomorphine, a nonselective DA agonist, impairs acquisition and consolidation of latent learning in ZF, characterized by prolonged latency to leave the start chamber, increased dwelling time in incorrect tunnels, and latency in reaching reward chambers . In the assay used here, zebrafish larvae become hyperactive in the dark following light stimulation (dark photokinesis) and exhibit nondirectional light‐seeking behavior proposed to be related to hunting for food and predator avoidance .…”

Section: Discussionmentioning

confidence: 99%

“…18,42 Apomorphine, a nonselective DA agonist, impairs acquisition and consolidation of latent learning in ZF, characterized by prolonged latency to leave the start chamber, increased dwelling time in incorrect tunnels, and latency in reaching reward chambers. 18 In the assay used here, zebrafish larvae become hyperactive in the dark following light stimulation (dark photokinesis) and exhibit nondirectional light-seeking behavior proposed to be related to hunting for food and predator avoidance. 26 Molecular studies have showed that there are direct connections between photosensory regions of the CNS and neurohormonal systems 43 ; indeed there is a close relationship between DA and light that can influence both physiology and behavior.…”

Section: Dmp Induces Hyperactivity In Zebrafish Larvaementioning

confidence: 99%

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Domperidone upregulates dopamine receptor expression and stimulates locomotor activity in larval zebrafish (Danio rerio)

Shontz

Souders

Schmidt

et al. 2018

Genes Brain and Behavior

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Dopamine (DA) plays a significant role in cognition, motor function and social behavior. The objectives of this study were to (1) quantify the temporal expression of transcripts (DA receptors, transporters and tyrosine hydroxylase) associated with DA signaling during early stages of zebrafish development and (2) determine their expression profiles following treatment with a D receptor antagonist domperidone (DMP). We also assessed locomotor behavior following treatment with DMP using alternating periods of light and dark (ie, dark photokinesis), as DA plays a key role in behavior. Relative expression levels of transcripts that were investigated and related to the DA system were detected after the first 24 hours postfertilization (hpf). Some DA receptor transcripts (eg, drd4c) increased in abundance earlier in the embryo compared with other receptors (eg, drd3), suggesting that DA receptor paralogs may have unique roles in development. Treatment of larvae with DMP resulted in the upregulation of DA receptor transcripts (ie, drd1, drd7, drd4b, drd4c) and DA transporter 1 (ie, slc6a3), and it is hypothesized that upregulation of genes related to the DA system is a compensatory neurophysiological response to DA receptor antagonism. Larval activity during dark photokinesis (measured by distance traveled) was also elevated by DMP. We hypothesize that behavioral responses observed with DMP may be related to the regulation of deep brain photoreception in zebrafish (Danio rerio) (ZF) larvae by DA.

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“…2C-D). The dopaminergic system is also critical to learning and memory formation 21 . Divided into two sub-groups, D1-like (D1 and D5 receptors) and D2-like (D2, D3 and D4 receptors) receptors are crucial to working memory and cognition-D1-like-and motivation and reward learning-D2-like 22 .…”

Section: Changes In Exploration Strategy Due To Pharmacological Blockmentioning

confidence: 99%

A Test of Memory: The Fish, The Mouse, The Fly And The Human

Fontana

Ranson

McBride³

et al. 2020

Preprint

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Simple mazes have provided numerous tasks for assessing working memory. The discrete nature of choices in the T-maze has provided a robust protocol with sensitivity to cognitive deficits, whilst the continuous Y-maze reduces manual handling and pre-trial training. We have combined these attributes to develop a new behavioural task for assessing working memory, the Free-movement pattern (FMP) Y-maze. Using sequentially recorded left and right turns we demonstrate that zebrafish and mice use a single dominant strategy predominantly consisting of alternations between left and right choices trial-to-trial. We further tested this protocol with Drosophila and discovered an alternative invertebrate search strategy. Finally, a virtual human FMP Y-maze confirmed a common strategy among all tested vertebrate species, validating the translational power of the task for human research. The FMP Y-maze combines robust investigation of working memory and high translational power, generating a simple task with far-reaching impact.

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Dopamine receptors participate in acquisition and consolidation of latent learning of spatial information in zebrafish (Danio rerio)

Cited by 29 publications

References 86 publications

Dopamine D1 receptor activation leads to object recognition memory in a coral reef fish

Dopamine D1 receptor activation leads to object recognition memory in a coral reef fish

Domperidone upregulates dopamine receptor expression and stimulates locomotor activity in larval zebrafish (Danio rerio)

A Test of Memory: The Fish, The Mouse, The Fly And The Human

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