Dopamine receptors in the striatum and limbic system of various strains of mice: Relation to differences in responses to apomorphine

Michaluk, Jerzy; Antkiewicz-Michaluk, Lucyna; Rokosz-Pelc, A; Sansone, Mario; Oliverio, Alberto; Vetulani, Jerzy

doi:10.1016/0091-3057(82)90104-6

Cited by 35 publications

(10 citation statements)

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“…The vigorous gnawing response of apo-sus rats after in agreement with results of previous studies in rats [7,11] and mice [8,15,25] showing that specifically striatal apomorphine administration suggested high dopamine redopaminergic receptor binding correlates with the intensity ceptor responsiveness. This assumption was substantiated of apomorphine-induced stereotypes.…”

Section: Discussionsupporting

confidence: 90%

Rats bred for enhanced apomorphine susceptibility have elevated tyrosine hydroxylase mRNA and dopamine D2-receptor binding sites in nigrostriatal and tuberoinfundibular dopamine systems

Rots¹,

Cools²,

Bérod³

et al. 1996

Brain Research

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From a Wistar population two rat lines were generated using as criterion the behavioral response to the dopamine agonist :e in :*1 F i* apomorphine. Rats of the apomorphine-susceptible (apo-sus) line revealed a vigorous gnawing response to i while the other rat line, the apomorphine-unsusceptible (apo-unsus) line, was selected for lack of response to the drug. In the present study using the 12th and 13th generation of these genetically selected lines, we have investigated whether this responsiveness was correlated with changes in dopamine neurochemistry. Therefore, we measured tyrosine hydroxylase ( No difference was found in the A 10 cell group of the VTA and the A 6 cell group of the locus coeruleus. The density of I)2 well as D, receptor mRNA levels in the striatal projection area of the A g substantia nigra neurons, were significantly elevated in apo-sus rats. Dopamine D2 receptor mRNA and D t receptor binding levels in caudate putamen and nucleus accumbens, however, were similar in rats of both lines. In conclusion, high apomorphine susceptibility is related to a potentially enhanced dopamine responsiveness selective for the nigrostriatal and tuberoinfundibular pathways.

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Section: Discussionsupporting

confidence: 90%

Rats bred for enhanced apomorphine susceptibility have elevated tyrosine hydroxylase mRNA and dopamine D2-receptor binding sites in nigrostriatal and tuberoinfundibular dopamine systems

Rots¹,

Cools²,

Bérod³

et al. 1996

Brain Research

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“…[ 3 H]Spiperone binding to D 2 -dopaminergic receptors in striatal membranes was measured essentially as described (Michaluk et al, 1982). The final pellet had been resuspended in 50 mM Tris HCl buffer (pH 7.4), containing 120 mM NaCl, 5 mM KCl, 2 mM CaCl 2 , 1 mM MgCl 2 , 10 μM pargyline, and 0.1% ascorbic acid.…”

Section: [ 3 H]spiperone Bindingmentioning

confidence: 99%

Chronic caffeine alters the density of adenosine, adrenergic, cholinergic, GABA, and serotonin receptors and calcium channels in mouse brain

et al. 1993

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SUMMARY1. Chronic ingestion of caffeine by male NIH strain mice alters the density of a variety of central receptors.2. The density of cortical A 1 adenosine receptors is increased by 20%, while the density of striatal A 2A adenosine receptors is unaltered.3. The densities of cortical β 1 and cerebellar β 2 adrenergic receptors are reduced by ca. 25%, while the densities of cortical α 1 and α 2 adrenergic receptors are not significantly altered.Densities of striatal D 1 and D 2 dopaminergic receptors are unaltered. The densities of cortical 5 HT 1 and 5 HT 2 serotonergic receptors are increased by 26-30%. Densities of cortical muscarinic and nicotinic receptors are increased by 40-50%. The density of cortical benzodiazepine-binding sites associated with GABA A receptors is increased by 65%, and the affinity appears slightly decreased. The density of cortical MK-801 sites associated with NMDA-glutaminergic receptors appear unaltered.4. The density of cortical nitrendipine-binding sites associated with calcium channels is increased by 18%.5. The results indicate that chronic ingestion of caffeine equivalent to about 100 mg/kg/day in mice causes a wide range of biochemical alterations in the central nervous system.

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“…Differences in dopamine D2 receptor-binding characteristics between different inbred mice and rat strains have been repeatedly confirmed. [16][17][18][19][20][21][22][23][24] In inbred mice strains a genome-wide search for catalepsy-related genes using a quantitative trait loci approach detected a locus near or at the DRD2.25 Therefore, also in humans several attempts have been performed searching for associations between dopamine D2 receptor polymorphisms and different measures of dopaminergic binding parameters or glucose metabolism in brain regions containing dopaminergic innervation (Table 1).In a recent PET investigation of Finnish healthy individuals the DRD2 TaqIA1 allele, suggested to be connected with alcoholism, 26 was associated with reduced striatal D2 receptor availability.3 So far there is no evidence that the DRD2 TaqIA polymorphism has a functional role. It has rather been assumed that the relationships obtained between the DRD2 TaqIA polymorphism and phenotype data are due to linkage disequilibrium between the DRD2 TaqIA polymorphism and another adjacent functional polymorphism.…”

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confidence: 99%

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Polymorphisms in the dopamine D2 receptor gene and their relationships to striatal dopamine receptor density of healthy volunteers

et al. 1999

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The density of striatal dopamine D2 receptors has been shown to vary considerably among healthy subjects. 1This variability might be due to genetic or environmental factors. In the present analysis we searched for relationships between dopamine D2 receptor gene (DRD2) polymorphisms and striatal dopamine D2 receptor density in vivo, as measured by positron emission tomography and [ 11 C]raclopride in 56 healthy subjects. There was a significant association between presence of a putative functional DRD2 promoter allele (−141C Del) and high striatal dopamine receptor density (t = 2.32, P = 0.02). In agreement with some previous studies 2-4 the presence of the DRD2 TaqIA1 allele was associated with measures of low dopamine receptor density (t = 2.58, P = 0.01). Also the DRD2 TaqIB1 allele was associated with low dopamine receptor density (t = 2.58, P = 0.01) wheras there was no significant relationship between another common silent intronic DRD2 short tandem repeat polymorphism (STRP) and striatal dopamine D2 receptor density. The results suggest that DRD2 genotypes may participate differentially in the regulation of striatal dopamine D2 receptor density in healthy human subjects. The results should be interpreted with caution because of the limited sample size.Positron emission tomography (PET) has been used to demonstrate a considerable variability of dopamine D2 receptor density in healthy subjects in vivo.1 This variability has recently been associated with the personality trait Detachment, 5 indicating that dopamine D2 receptor density may have functional importance for personality characteristics in human subjects. A fundamental issue is the extent to which the dopamine D2 receptor variability is due to environmental influences or genetic contributions. A number of environmental influences such as antipsychotic medication, 6 age 7-9 and menstrual phases 10 have been suggested to alter dopamine D2 receptor density. Low dopamine D2 receptor binding in subjects with alcohol, 11,12 cocaine, 13,14 and opiate 15 dependence may suggest that these drugs also have an effect on D2 receptor density. However, the degree to which these factors may alter the receptor density cannot explain the two to threefold variability seen among healthy subjects.1 Animal data suggest a genetic contribution to the variation in dopamine receptor density. Differences in dopamine D2 receptor-binding characteristics between different inbred mice and rat strains have been repeatedly confirmed. [16][17][18][19][20][21][22][23][24] In inbred mice strains a genome-wide search for catalepsy-related genes using a quantitative trait loci approach detected a locus near or at the DRD2.25 Therefore, also in humans several attempts have been performed searching for associations between dopamine D2 receptor polymorphisms and different measures of dopaminergic binding parameters or glucose metabolism in brain regions containing dopaminergic innervation (Table 1).In a recent PET investigation of Finnish healthy individuals the DRD2 TaqIA1 allele, suggeste...

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Dopamine receptors in the striatum and limbic system of various strains of mice: Relation to differences in responses to apomorphine

Cited by 35 publications

References 13 publications

Rats bred for enhanced apomorphine susceptibility have elevated tyrosine hydroxylase mRNA and dopamine D2-receptor binding sites in nigrostriatal and tuberoinfundibular dopamine systems

Rats bred for enhanced apomorphine susceptibility have elevated tyrosine hydroxylase mRNA and dopamine D2-receptor binding sites in nigrostriatal and tuberoinfundibular dopamine systems

Chronic caffeine alters the density of adenosine, adrenergic, cholinergic, GABA, and serotonin receptors and calcium channels in mouse brain

Polymorphisms in the dopamine D2 receptor gene and their relationships to striatal dopamine receptor density of healthy volunteers

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