Dopamine receptor DOP-4 modulates habituation to repetitive photoactivation of a <i>C. elegans</i> polymodal nociceptor

Ardiel, Evan L.; Giles, Andrew C.; Yu, Alex J.; Lindsay, Theodore H.; Lockery, Shawn R.; Rankin, Catharine H.

doi:10.1101/lm.041830.116

Cited by 50 publications

(60 citation statements)

References 56 publications

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“…[39,65] Indeed, C. elegans displays many aspects of plasticity, including learning and memory, [66][67][68] in the absence of which navigational trajectories become more random, less ordered, and less directional. [39,65] Indeed, C. elegans displays many aspects of plasticity, including learning and memory, [66][67][68] in the absence of which navigational trajectories become more random, less ordered, and less directional.…”

Section: Rudimentary Neural Circuits That Mediate Sensorimotor Computmentioning

confidence: 99%

Prominent Inhibitory Projections Guide Sensorimotor Computation: An Invertebrate Perspective

Hughes

Celikel

2019

BioEssays

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From single-cell organisms to complex neural networks, all evolved to provide control solutions to generate context-and goal-specific actions. Neural circuits performing sensorimotor computation to drive navigation employ inhibitory control as a gating mechanism as they hierarchically transform (multi)sensory information into motor actions. Here, the focus is on this literature to critically discuss the proposition that prominent inhibitory projections form sensorimotor circuits. After reviewing the neural circuits of navigation across various invertebrate species, it is argued that with increased neural circuit complexity and the emergence of parallel computations, inhibitory circuits acquire new functions. The contribution of inhibitory neurotransmission for navigation goes beyond shaping the communication that drives motor neurons, and instead includes encoding of emergent sensorimotor representations. A mechanistic understanding of the neural circuits performing sensorimotor computations in invertebrates will unravel the minimum circuit requirements driving adaptive navigation.

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Section: Rudimentary Neural Circuits That Mediate Sensorimotor Computmentioning

confidence: 99%

Prominent Inhibitory Projections Guide Sensorimotor Computation: An Invertebrate Perspective

Hughes

Celikel

2019

BioEssays

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“…As reported in Ardiel et al. (), light stimuli of different intensities and durations evoke responses of different likelihoods and magnitudes. Light stimuli of higher intensities and/or longer durations evoke more robust responses.…”

Section: Commentarymentioning

confidence: 54%

“…Here, we describe a detailed basic protocol that uses our high‐throughput behavioral tracking system, the Multi‐Worm Tracker (freely available at https://sourceforge.net/projects/mwt/), in conjunction with a low‐cost and effective custom‐built light‐emitting diode (LED) light source (Support Protocol 1) and a cofactor solution (Support Protocol 2) to study the behavior of populations of freely behaving C. elegans under the control of optogenetics (Ardiel et al., , ). This method is versatile and is easy to adapt to other worm‐tracking systems.…”

Section: Introductionmentioning

confidence: 99%

High‐Throughput Analysis of Behavior Under the Control of Optogenetics in Caenorhabditis elegans

McDiarmid

Ardiel

et al. 2018

CP Neuroscience

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In this unit, we describe an inexpensive and versatile method for optogenetic stimulation of a large population of genetically engineered Caenorhabditis elegans worms while quantitatively analyzing behavior. A custom light‐emitting diode light source is used to deliver blue‐light stimuli, causing direct depolarization of neurons expressing the light‐gated cation channel Channelrhodopsin‐2, which in turn evokes behavioral responses. The behavioral responses are recorded by a high‐throughput machine vision–based tracking system, the Multi‐Worm Tracker, for detailed analysis. This approach allows researchers to bypass technical obstacles to simultaneously deliver uniform stimuli to a large number of freely behaving animals and investigate the neural underpinnings of behavior. © 2018 by John Wiley & Sons, Inc.

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“…Previous studies have implicated both monoamine and peptide neuromodulators in driving sensitization in many species . Thus, we hypothesized that neuromodulators may be required for the information processing in cross‐modal integration in PVC.…”

Section: Resultsmentioning

confidence: 98%

Multimodal Stimulation in a Microfluidic Device Facilitates Studies of Interneurons in Sensory Integration in C. elegans

Cho

Lee

Chew

et al. 2020

Small

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Animals' perception and behavior involve integration of multiple sensory modalities. Caenorhabditis elegans is a useful model for studying multimodal sensory integration, as it has well‐characterized neuronal circuits in a relatively simple nervous system. However, most studies based on functional imaging have only been conducted on single modal stimuli, because well‐controlled multimodal experiments for C. elegans are technically difficult. For instance, no single systems currently deliver precise stimuli with spatial, temporal, and intensity control, despite prior hypotheses that interneurons do integrate these sensory inputs to control behavior. Here, a microfluidic platform that can easily deliver spatially and temporally controlled combination stimuli to C. elegans is presented. With this platform, both sensory and interneuron activity is measured in response to mechanical and chemical stimulations in a quantitative and high‐throughput manner. It is found that the activity of command interneuron PVC can be modulated by prior stimulation both within the same and across different modalities. The roles of monoaminergic and peptidergic signaling are further examined on the process of multimodal integration through PVC activity. The approach exemplified here is envisioned to be broadly applicable in different contexts to elucidate underlying mechanisms and identify genes affecting multisensory integration.

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Dopamine receptor DOP-4 modulates habituation to repetitive photoactivation of a C. elegans polymodal nociceptor

Cited by 50 publications

References 56 publications

Prominent Inhibitory Projections Guide Sensorimotor Computation: An Invertebrate Perspective

Prominent Inhibitory Projections Guide Sensorimotor Computation: An Invertebrate Perspective

High‐Throughput Analysis of Behavior Under the Control of Optogenetics in Caenorhabditis elegans

Multimodal Stimulation in a Microfluidic Device Facilitates Studies of Interneurons in Sensory Integration in C. elegans

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