Dopamine receptor D2 polymorphism is associated with alleviation of obesity after 8-year follow-up: a retrospective cohort study in obese Chinese children and adolescents

Zhu, Jian; Chen, Lianhui; Yuan, Ke; Li, Liang; Wang, Chunlin

doi:10.1631/jzus.b1800155

Cited by 6 publications

(4 citation statements)

References 24 publications

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“…Previous study has reported the regulatory role of DRD2 gene in metabolism through mediating food intake behavior. In a study on childhood obesity, the rs2075654 polymorphism of DRD2 gene was determined to be associated with long-term obesity alleviation in obese Chinese children and adolescents [Zhu et al, 2018]. Besides, Cardel et al have also reported the close relationship between the Taq1a polymorphism (rs1800497) of DRD2 gene with diet and adiposity in a multi-ethnic cohort of children [Cardel et al, 2019].…”

Section: Discussionmentioning

confidence: 99%

Analysis of Dopamine Receptor D2 Gene Polymorphism and Correlation with Dyslipidemia in the Chinese Population

Tan,

Wang,

Zhang

et al. 2023

Mol Syndromol

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Objective: The study aimed to explore the genotype and allele distributions of dopamine D2-like receptor (DRD2) gene -141C and C957T polymorphisms in the Chinese Han population with dyslipidemia, as well as their association with serum lipid levels. Methods: One hundred fifty patients with dyslipidemia and 150 healthy people were recruited as the case and the control groups, respectively. Serum total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol levels were detected. The target sequence of DRD2 polymorphisms was amplified by polymerase chain reaction and genotyped via Sanger sequencing. Results: In DRD2 gene C957T (rs6277), three genotypes of CC, CT, and TT were detected with the frequencies of 92.67%, 6.67%, 0.67% in dyslipidemia cases, and 83.33%, 14.67%, 2.00% in the controls, respectively. The CT genotype and T allele frequencies were significantly low in the case group relative to the control group. After adjusting to other clinical indicators, the CT genotype of C957T polymorphism (hazard ratio = 0.401, 95% confidence interval = 0.181–0.890, p < 0.05) was still related to a significantly reduced risk of dyslipidemia. The C957T CT genotype carriers had the lowest values of serum TC, TG, LDL, and the highest values of serum HDL-C. Conclusion: DRD2 gene C957T polymorphism was an independent influencing factor associated with the susceptibility to dyslipidemia, and the CT genotype was associated with decreased odds of susceptibility to dyslipidemia.

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Section: Discussionmentioning

confidence: 99%

Analysis of Dopamine Receptor D2 Gene Polymorphism and Correlation with Dyslipidemia in the Chinese Population

Tan,

Wang,

Zhang

et al. 2023

Mol Syndromol

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“…At first glance, it may seem contradictory that individuals with a genetic susceptibility to addictive eating and obesity would have such a positive response to bariatric surgery. However, compliance to addiction treatment has been observed in alcoholics with the A1 polymorphism [103]. Bromocriptine treatment (dopamine agonist therapy) proved to produce the most significant attenuations in craving and anxiety amongst A1 carrier alcoholics [103].…”

Section: Discussionmentioning

confidence: 99%

“…However, compliance to addiction treatment has been observed in alcoholics with the A1 polymorphism [103]. Bromocriptine treatment (dopamine agonist therapy) proved to produce the most significant attenuations in craving and anxiety amongst A1 carrier alcoholics [103]. This genotype was associated with reductions in body weight, fat mass, and BMI after among subjects who underwent resistance training and calorie restriction for weight loss.…”

Section: Discussionmentioning

confidence: 99%

Genetic Correlates as a Predictor of Bariatric Surgery Outcomes after 1 Year

Thanos,

Hanna,

Mihalkovic

et al. 2023

Biomedicines

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This study analyzed genetic risk assessments in patients undergoing bariatric surgery to serve as a predictive factor for weight loss parameters 1 year after the operation. Thirty (30) patients were assessed for Genetic Addiction Risk Severity (GARS), which analyzes neurogenetic polymorphisms involved in addiction and reward deficiency. Genetic and psychosocial data collected before the operation were correlated with weight loss data, including changes in weight, body mass index (BMI), and percent of expected weight loss (%EWL). Results examined correlations between individual gene risk alleles, 1-year body weight data, and psychosocial trait scores. Spearman’s correlations revealed that the OPRM1 (rs1799971) gene polymorphism had significant negative correlation with 1-year weight (rs = −0.4477, p < 0.01) and BMI (rs = −0.4477, p < 0.05). In addition, the DRD2 risk allele (rs1800497) was correlated negatively with BMI at 1 year (rs = −0.4927, p < 0.05), indicating that one risk allele copy was associated with lower BMI. However, this allele was positively correlated with both ∆Weight (rs = 0.4077, p < 0.05) and %EWL (rs = 0.5521, p < 0.05) at 1 year post-surgery. Moreover, the overall GARS score was correlated with %EWL (rs = 0.4236, p < 0.05), ∆Weight (rs = 0.3971, p < 0.05) and ∆BMI (rs = 0.3778, p < 0.05). Lastly, Food Cravings Questionnaire (FCQ) scores were negatively correlated with %EWL (rs = −0.4320, p < 0.05) and ∆Weight at 1 year post-surgery (rs = −0.4294, p < 0.05). This suggests that individuals with a higher genetic addiction risk are more responsive to weight loss treatment, especially in the case of the DRD2 polymorphism. These results should translate clinically to improve positivity and attitude related to weight management by those individuals born with the risk alleles (rs1800497; rs1799971).

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“…45,46 A retrospective cohort study in Chinese children and adolescents with obesity also found that DRD2 rs2075654 is related to long-term remission of obesity. 47 Similarly, the polymorphism of the brain-derived neurotrophic factor (BDNF) Val66Met is associated with Conscientiousness and obesity in adolescents. 48,49…”

Section: Confoundingmentioning

confidence: 99%

The association of personality traits with childhood obesity: a systematic review and meta-analysis

Jiang

Huang

Chen

et al. 2022

Preprint

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A growing body of evidence has shown the association of personality with obesity, but findings of such studies in children remain mixed. This review aimed to systematically summarize the existing literature regarding the association between personality and childhood obesity and explore the underlying mechanisms. A meta-analysis was performed based on the data from 12 included studies and personality traits were classified into five domains (Extraversion, Agreeableness, Conscientiousness, Neuroticism, and Openness) based on the five-factor model. Conscientiousness was significantly associated with BMI across 2 studies and the pooled correlation coefficient was -0.09 (95% CI: -0.17 to 0.00; I2 = 0%); another 3 studies indicated a significant difference in Conscientiousness between children with obesity and those with normal weight, and the pooled SMD was -0.08 (95% CI: -0.13 to -0.03; I2 = 66%). No consistent patterns were found in the associations between other personality traits and childhood obesity. We hypothesized three possible pathways (moderation, mediation, and confounding) underlying the personality-obesity associations. Findings of our review indicate that, within the context of childhood obesity interventions, identification of subgroups of children with specific personality traits is necessary, especially for measures of Conscientiousness.

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Dopamine receptor D2 polymorphism is associated with alleviation of obesity after 8-year follow-up: a retrospective cohort study in obese Chinese children and adolescents

Cited by 6 publications

References 24 publications

Analysis of Dopamine Receptor D2 Gene Polymorphism and Correlation with Dyslipidemia in the Chinese Population

Analysis of Dopamine Receptor D2 Gene Polymorphism and Correlation with Dyslipidemia in the Chinese Population

Genetic Correlates as a Predictor of Bariatric Surgery Outcomes after 1 Year

The association of personality traits with childhood obesity: a systematic review and meta-analysis

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