Dopamine Receptor D1/D5 Gene Expression in the Medial Prefrontal Cortex Predicts Impulsive Choice in Rats

Loos, Maarten; Pattij, Tommy; Janssen, Mieke C. W.; Counotte, Danielle S.; Schoffelmeer, Anton N. M.; Smit, August B.; Spijker, Sabine; Gaalen, Marcel M. van

doi:10.1093/cercor/bhp167

Cited by 84 publications

(83 citation statements)

References 53 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As previously mentioned, dopamine release in the mPFC plays a role in enhancing the control of impulsive behavior (Sokolowski and Salamone 1994;Loos et al 2010). Meanwhile, increased dopamine release in the NAc stimulates impulsive behavior (Cole and Robbins 1987;Pattij et al 2006).…”

Section: Discussionmentioning

confidence: 90%

“…The rat mPFC is implicated in various aspects of impulsivity (Passetti et al 2002;Chudasama et al 2003;Gill et al 2010;Loos et al 2010). The infralimbic cortex (IL), the ventral portion of the mPFC, plays a pivotal role in the control of impulsive action Murphy et al 2005;Tsutsui-Kimura et al 2010).…”

Section: Introductionmentioning

confidence: 99%

“…The infralimbic cortex (IL), the ventral portion of the mPFC, plays a pivotal role in the control of impulsive action Murphy et al 2005;Tsutsui-Kimura et al 2010). A previous study reported that dopamine release in the mPFC plays a role in enhancing the control of impulsive behavior (Sokolowski and Salamone 1994;Loos et al 2010). linked to an inhibition of cAMP production (Cooper et al 2003;Jose et al 2007).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Milnacipran enhances the control of impulsive action by activating D1-like receptors in the infralimbic cortex

et al. 2012

View full text Add to dashboard Cite

Rationale: Elevated impulsivity is often observed in patients with depression.We recently found that milnacipran, an antidepressant and a serotonin/noradrenaline reuptake inhibitor, could enhance impulse control in rats. However, the neural mechanisms underlying the effects of milnacipran on impulsive action remain unclear.Milnacipran increases not only extracellular serotonin and noradrenaline but also dopamine specifically in the medial prefrontal cortex, which is one of brain regions responsible for impulsive action.

show abstract

Section: Discussionmentioning

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Milnacipran enhances the control of impulsive action by activating D1-like receptors in the infralimbic cortex

et al. 2012

View full text Add to dashboard Cite

show abstract

“…All drugs were dissolved in physiological 0.9% saline, sonicated until dissolved, and protected from light. The selected doses have all been well documented by both our group and others to be behaviorally active when given intracerebrally (Seamans et al, 1998;Ragozzino, 2002;Chudasama and Robbins, 2004;Haluk and Floresco, 2009;Loos et al, 2010).…”

Section: Methodsmentioning

confidence: 88%

“…However, there have been comparatively few studies investigating the contribution of PFC DA transmission to different forms of cost/benefit decision making. Reducing DA activity in the anterior cingulate alters effort-based decisions (Schweimer et al, 2005;Schweimer and Hauber, 2006), whereas blockade or stimulation of medial PFC D 1 receptors reduces preference for larger, delayed rewards (Loos et al, 2010). Notably, there have been no studies investigating the contribution of different PFC DA receptors to risk-based decision making.…”

Section: Introductionmentioning

confidence: 99%

Dissociable Contributions by Prefrontal D1 and D2 Receptors to Risk-Based Decision Making

Onge

Abhari²,

Floresco³

2011

Journal of Neuroscience

162

142

View full text Add to dashboard Cite

Choices between certain and uncertain rewards of different magnitudes have been proposed to be mediated by both the frontal lobes and the mesocorticolimbic dopamine (DA) system. In rats, systemic manipulations of DA activity or inactivation of the medial prefrontal cortex (PFC) disrupt decision making about risks and rewards. However, it is unclear how PFC DA transmission contributes to these processes. We addressed this issue by examining the effects of pharmacological manipulations of D 1 and D 2 receptors in the medial (prelimbic) PFC on choice between small, certain and large, yet probabilistic rewards. Rats were trained on a probabilistic discounting task where one lever delivered one pellet with 100% probability, and the other delivered four pellets, but the probability of receiving reward decreased across blocks of trials (100, 50, 25, 12.5%). D 1 blockade (SCH23390) in the medial PFC decreased preference for the large/risky option. In contrast, D 2 blockade (eticlopride) reduced probabilistic discounting and increased risky choice. The D 1 agonist SKF81297 caused a slight, nonsignificant increase in preference for the large/risky lever. However, D 2 receptor stimulation (quinpirole) induced a true impairment in decision making, flattening the discounting curve and biasing choice away from or toward the risky option when it was more or less advantageous, respectively. These findings suggest that PFC D 1 and D 2 receptors make dissociable, yet complementary, contributions to risk/reward judgments. By striking a fine balance between D 1 /D 2 receptor activity, DA may help refine these judgments, promoting either exploitation of current favorable circumstances or exploration of more profitable ones when conditions change.

show abstract

Anxiety, aggression, reward sensitivity, and forebrain dopamine receptor expression in a laboratory rat model of early‐life disadvantage

Lonstein,

Vitale,

Olekanma

et al. 2023

Developmental Psychobiology

View full text Add to dashboard Cite

Despite early‐life disadvantage (ELD) in humans being a highly heterogenous construct, it consistently predicts negative neurobehavioral outcomes. The numerous environmental contributors and neural mechanisms underlying ELD remain unclear, though. We used a laboratory rat model to evaluate the effects of limited resources and/or heavy metal exposure on mothers and their adult male and female offspring. Dams and litters were chronically exposed to restricted (1‐cm deep) or ample (4‐cm deep) home cage bedding postpartum, with or without lead acetate (0.1%) in their drinking water from insemination through 1‐week postweaning. Restricted‐bedding mothers showed more pup‐directed behaviors and behavioral fragmentation, while lead‐exposed mothers showed more nestbuilding. Restricted bedding‐raised male offspring showed higher anxiety and aggression. Either restricted bedding or lead exposure impaired goal‐directed performance in a reinforcer devaluation task in females, whereas restricted bedding alone disrupted it in males. Lead exposure, but not limited bedding, also reduced sucrose reward sensitivity in a progressive ratio task in females. D1 and D2 receptor mRNA in the medial prefrontal cortex and nucleus accumbens (NAc) were each affected by the early‐life treatments and differently between the sexes. Most notably, adult males (but not females) exposed to both early‐life treatments had greatly increased D1 receptor mRNA in the NAc core. These results illuminate neural mechanisms through which ELD threatens neurobehavioral development and highlight forebrain dopamine as a factor.

show abstract

Dopamine Receptor D1/D5 Gene Expression in the Medial Prefrontal Cortex Predicts Impulsive Choice in Rats

Cited by 84 publications

References 53 publications

Milnacipran enhances the control of impulsive action by activating D1-like receptors in the infralimbic cortex

Milnacipran enhances the control of impulsive action by activating D1-like receptors in the infralimbic cortex

Dissociable Contributions by Prefrontal D1 and D2 Receptors to Risk-Based Decision Making

Anxiety, aggression, reward sensitivity, and forebrain dopamine receptor expression in a laboratory rat model of early‐life disadvantage

Contact Info

Product

Resources

About