Dopamine output in the nucleus accumbens shell is related to the acquisition and the retention of a motivated appetitive behavior in rats

Masi, Flavio; Scheggi, Simona; Mangiavacchi, Simona; Tolu, Pierluigi; Tagliamonte, A.; Montis, Maria Graziella De; Gambarana, Carla

doi:10.1016/s0006-8993(01)02442-8

Cited by 15 publications

(17 citation statements)

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“…This finding is consistent with other studies demonstrating that DA transmission in the NAc shell is important in the acquisition of motivated behaviors and motivational learning in particular (8,17,21,41,42). Our findings demonstrated that animals treated with the opioid antagonist LY255582 did not show a rise in NAc shell DA levels in response to the same amount of HP diet that elicited an increase in DA levels in the pair-fed animals.…”

Section: Discussionsupporting

confidence: 93%

“…More specifically, manipulations of the opioid system regulate hedonic feeding or the intake and response to highly palatable (HP) macronutrients (high-fat and/or high-sucrose) (5,6,33,37). The acquisition of hedonic feeding appears to involve activation of the mesolimbic dopamine (DA) system, the dopaminergic projection from the ventral tegmental area to the nucleus accumbens (NAc) (8,11,17,21,41,42). This pathway is a key component of the brain reward circuit (33,60) that consists of neural pathways strongly implicated in reward and reinforcement mechanisms of drugs of abuse, as well as vital behaviors, including feeding and sexual behavior.…”

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confidence: 99%

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Activation of mesolimbic dopamine neurons during novel and daily limited access to palatable food is blocked by the opioid antagonist LY255582

Sahr¹,

Sindelar²,

Alexander-Chacko³

et al. 2008

American Journal of Physiology-Regulatory, Integrative and Comp

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Sahr AE, Sindelar DK, Alexander-Chacko JT, Eastwood BJ, Mitch CH, Statnick MA. Activation of mesolimbic dopamine neurons during novel and daily limited access to palatable food is blocked by the opioid antagonist LY255582. Am J Physiol Regul Integr Comp Physiol 295: R463-R471, 2008. First published June 4, 2008 doi:10.1152/ajpregu.00390.2007.-An analog of the trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidine series (LY255582) exhibits high in vitro binding affinity and antagonist potency for the -, ␦-, and -opioid receptors. In vivo, LY255582 exhibits potent effects in reducing food intake and body weight in several rodent models of obesity. In the present study, we evaluated the effects of LY255582 to prevent the consumption of a highly palatable (HP) diet (a high-fat/ high-carbohydrate diet) both when the food was novel and following daily limited access to the HP diet. Additionally, we examined the effects of consumption of the HP diet and of LY255582 treatment on mesolimbic dopamine (DA) signaling by in vivo microdialysis. Consumption of the HP diet increased extracellular DA levels within the nucleus accumbens (NAc) shell. Increased DA in the NAc shell was not related to the quantity of the HP diet consumed, and the DA response did not habituate following daily scheduled access to the HP diet. Interestingly, treatment with LY255582 inhibited consumption of the HP diet and the HP diet-associated increase in NAc shell DA levels. Moreover, the increased HP diet consumption observed following daily limited access to the HP diet was completely prevented by LY255582 treatment. LY255582 may be a useful tool in understanding the neural mechanisms involved in the reinforcement mechanisms regulating food intake. opiate; nucleus accumbens; obesity; food intake; microdialysis INVOLVEMENT OF THE CENTRAL opioid system in the regulation of food intake is well established (for review, see Refs. 22 and 49). Many studies have demonstrated that agonists at all three opioid receptor subtypes, , ␦, and , increase food intake (26, 44), whereas antagonists decrease food intake (22, 49). More specifically, manipulations of the opioid system regulate hedonic feeding or the intake and response to highly palatable (HP) macronutrients (high-fat and/or high-sucrose) (5, 6, 33, 37). The acquisition of hedonic feeding appears to involve activation of the mesolimbic dopamine (DA) system, the dopaminergic projection from the ventral tegmental area to the nucleus accumbens (NAc) (8,11,17,21,41,42). This pathway is a key component of the brain reward circuit (33, 60) that consists of neural pathways strongly implicated in reward and reinforcement mechanisms of drugs of abuse, as well as vital behaviors, including feeding and sexual behavior. Several neurotransmitter and neuropeptide systems that modulate feeding do so, at least in part, by acting through the mesolimbic DA pathway (1, 36, 59). Endogenous opioids regulate the mesolimbic DA projection at both the level of the ventral tegmental area and NAc (30, 54), providing a potential mech...

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Section: Discussionsupporting

confidence: 93%

mentioning

confidence: 99%

Activation of mesolimbic dopamine neurons during novel and daily limited access to palatable food is blocked by the opioid antagonist LY255582

Sahr¹,

Sindelar²,

Alexander-Chacko³

et al. 2008

American Journal of Physiology-Regulatory, Integrative and Comp

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“…Moreover, a drug able to restore the tendency to engage in dopamine stimulating behaviours in a condition of decreased dopaminergic transmission can be proposed to have anti-anhedonic activity. Interestingly, rats that have acquired VAB show a tonically increased dopamine output in the medial prefrontal cortex and NAcS (Masi et al, 2001) ; that is, VAB acquisition models a behavioural pattern that maintains elevated dopaminergic transmission. Thus, the finding that lithium treatment restored the dopaminergic response to VS consumption and the competence to acquire VAB in rats exposed to repeated unavoidable stress before or during Y-maze training allows for the conclusion that lithium is endowed with anti-anhedonic activity.…”

Section: Discussionmentioning

confidence: 99%

Anti-anhedonic activity of long-term lithium treatment in rats exposed to repeated unavoidable stress

Marchese

Scheggi

Secci

et al. 2013

International Journal of Neuropsychopharmacology

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Behavioural and neurochemical responses to palatable food exposure represent an index of hedonic competence. In rats, a palatable meal increases extra-neuronal dopamine levels in the nucleus accumbens shell (NAcS) that confers to it incentive salience and reinforcing value. Repeated stress exposure decreases dopamine output and impairs the NAcS dopaminergic response to palatable food and the competence to acquire a vanilla sugar (VS)-reinforced instrumental behaviour [VS-sustained appetitive behaviour (VAB)]. Moreover, chronic stress exposure disrupts reactivity to aversive stimuli. A 3-wk treatment with lithium, the gold-standard treatment in bipolar disorder, tonically reduces NAcS dopamine output and the reactivity to aversive stimuli. However, it does not affect the dopaminergic response to VS and the competence to acquire VAB. This study investigated whether repeated lithium administration is endowed with anti-anhedonic activity. The NAcS dopaminergic response to VS and the competence to acquire VAB and sucrose self-administration (SA), in terms of fixed-ratio (FR)1, FR5 and progressive ratio schedules of reinforcement, were studied in saline or lithium-treated groups of non-food-deprived rats exposed or not to repeated unavoidable stress. Chronic stress exposure impaired the NAcS dopaminergic response to VS, acquisition of VAB and sucrose SA, in terms of FR1 and FR5 schedules of reinforcement and breaking point score. Repeated lithium treatment restored these parameters to control group values, even when treatment began in rats already showing an anhedonia-like condition. Since the breaking point defines the reinforcement efficacy of a hedonic stimulus, the present data suggest that lithium treatment is endowed with anti-anhedonic activity in rats.

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“…Preclinical studies have shown that cortisol interacts with the rewarding properties of drugs of abuse by altering mesocorticolimbic dopamine neurotransmission (Belujon & Grace, 2011;Kosten, Zhang, & Kehoe, 2003;Lu, Liu, Huang, & Zhang, 2003;Marinelli & Piazza, 2002;Masi et al, 2001;Miczek, Nikulina, Shimamoto, & Covington, 2011;Saal, Dong, Bonci, & Malenka, 2003;Shimamoto, Debold, Holly, & Miczek, 2011;Yavich & Tiihonen, 2000). Indeed, glucocorticoids and stress interact with the dopamine reward system in ways that increase vulnerability for addiction (Marinelli & Piazza, 2002).…”

Section: Dopaminergic Reward Systemsmentioning

confidence: 99%

The Potential Role of Glucocorticoids and the HPA Axis in Alcohol Dependence

Stephens

McCaul

Wand

2014

Neurobiology of Alcohol Dependence

297

371

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Dopamine output in the nucleus accumbens shell is related to the acquisition and the retention of a motivated appetitive behavior in rats

Cited by 15 publications

References 17 publications

Activation of mesolimbic dopamine neurons during novel and daily limited access to palatable food is blocked by the opioid antagonist LY255582

Activation of mesolimbic dopamine neurons during novel and daily limited access to palatable food is blocked by the opioid antagonist LY255582

Anti-anhedonic activity of long-term lithium treatment in rats exposed to repeated unavoidable stress

The Potential Role of Glucocorticoids and the HPA Axis in Alcohol Dependence

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