Dopamine modulates neuronal excitability pre- and post-synaptically in the rat subfornical organ

Miyahara, Nobutaka; Ono, Kentaro; Hitomi, Suzuro; Hirase, Masaki; Inenaga, Kiyotoshi

doi:10.1016/j.brainres.2012.01.063

Cited by 6 publications

(3 citation statements)

References 33 publications

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“…It has been reported that an i.c.v. injection of dopamine suppresses water intake [67]. These findings are consistent with the suppression of dopamine release by a high dose of EtOH, which, in turn, may represent an additional pathway that increases thirst sensation (or sodium appetite) after heavy-alcohol drinking.…”

Section: Acetaldehyde Induces Thirst Sensationsupporting

confidence: 79%

Thirst sensation and oral dryness following alcohol intake

Inenaga

Ono

Hitomi

et al. 2017

Japanese Dental Science Review

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SummarySubstantial acute and chronic intakes of alcohol or ethanol (EtOH) severely influence oral sensations, such as thirst and oral dryness (dry mouth, xerostomia). Thirst sensation and oral dryness are primarily caused by the activation of neurons in brain regions, including the circumventricular organs and hypothalamus, which are referred to as the dipsogenic center, and by a decrease in salivary secretion, respectively. The sensation of thirst experienced after heavy-alcohol drinking is widely regarded as a consequence of EtOH-induced diuresis; however, EtOH in high doses induces anti-diuresis. Recently, it has been proposed that the ethanol metabolite acetaldehyde induces thirst via two distinct processes in the central nervous system from EtOH-induced diuresis, based on the results of animal experiments. The present review describes new insights regarding the induction mechanism of thirst sensation and oral dryness after drinking alcohol.

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Section: Acetaldehyde Induces Thirst Sensationsupporting

confidence: 79%

Thirst sensation and oral dryness following alcohol intake

Inenaga

Ono

Hitomi

et al. 2017

Japanese Dental Science Review

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“…Of note, we did not detect any significant change in burst size, which is also used as a measure of hedonic impact (D'Aquila, ). Therefore, more work is needed to elucidate the mechanism(s) by which D1 agonists ameliorate the water drinking behaviour of DSI mice, which may involve alterations in postingestive feedback and basal thirst (Bouchaud & Bosler, ; Miyahara, Ono, Hitomi, Hirase, & Inenaga, ). Nevertheless, the restoration of the drinking behaviour in DSI mice is evidence that the D1 receptor agonist A68930 may be a drug candidate to treat illnesses related to mild to moderate DA loss, including anorexia nervosa, as suggested by G. K. W. Frank (Frank, ).…”

Section: Discussionmentioning

confidence: 99%

Differential effects of dopamine D1‐like and D2‐like receptor agonists on water drinking behaviour under thirsty conditions in mice with reduced dopamine secretion

Kao

Hisatsune

2019

Eur J of Neuroscience

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The mesolimbic dopamine system is important for reward‐oriented behaviours, such as drinking and eating. However, the precise involvement of dopaminergic neurons and dopamine receptors in water drinking behaviour remains unclear. Here, we generated triple transgenic mice harbouring Slc6a3(DAT)‐icre/ERT2, Camk2a‐loxP‐STOP‐loxP‐tetracycline transactivator and tetO‐tetanus toxin constructs, in which the release of dopamine is blocked by tetanus toxin. These mice, referred to as dopamine secretion interference mice, had reduced dopamine secretion in the striatum (61.4%) and the nucleus accumbens (54.5%). They showed adequate limb strength and food consumption, similarly to control mice, but exhibited motor control impairment in a challenging rotarod test. Dopamine secretion interference mice made fewer licks and had fewer bursts than control mice during a licking test under thirsty conditions. To elucidate the influence of dopamine receptors in the altered drinking behaviour, a dopamine D1 or D2/D3 receptor agonist (A68930 or ropinirole, respectively) was administered prior to the licking microstructure analysis. Treatment with the D1 agonist restored the total number of licks but not the burst number in dopamine secretion interference mice. By contrast, the D2/3 agonist impeded water drinking behaviour in both transgenic and control mice. The present findings indicate that D1 receptor activation partially ameliorates the altered drinking behaviour of the dopamine secretion interference mice and suggest that D1 receptor activity impacts drinking under thirsty conditions.

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“…The concentrations of L-dopa and catecholamines were 50 nmol 50 μl −1 , based on a previous study showing moderate heat hypersensitivity in the hind paw following local injection of norepinephrine at 20–200 nmol 30 μl −1 62 . The three dopamine receptor agonists were administered at a lower concentration (15 nmol) than that of dopamine, based on a previous in vitro study showing that 30% lower concentrations of the agonists induced similar neuronal activity to dopamine 63 . The SCH23390 and entacapone concentrations were 50 nmol and the kojic acid concentration was 1.5 μmol.…”

Section: Methodsmentioning

confidence: 99%

Cutaneous pigmentation modulates skin sensitivity via tyrosinase-dependent dopaminergic signalling

Ono

Viet

et al. 2017

Sci Rep

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We propose a new mechanism of sensory modulation through cutaneous dopaminergic signalling. We hypothesize that dopaminergic signalling contributes to differential cutaneous sensitivity in darker versus lighter pigmented humans and mouse strains. We show that thermal and mechanical cutaneous sensitivity is pigmentation dependent. Meta-analyses in humans and mice, along with our own mouse behavioural studies, reveal higher thermal sensitivity in pigmented skin relative to less-pigmented or albino skin. We show that dopamine from melanocytes activates the D1-like dopamine receptor on primary sensory neurons. Dopaminergic activation increases expression of the heat-sensitive TRPV1 ion channel and reduces expression of the mechanically-sensitive Piezo2 channel; thermal threshold is lower and mechanical threshold is higher in pigmented skin.

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Dopamine modulates neuronal excitability pre- and post-synaptically in the rat subfornical organ

Cited by 6 publications

References 33 publications

Thirst sensation and oral dryness following alcohol intake

Thirst sensation and oral dryness following alcohol intake

Differential effects of dopamine D1‐like and D2‐like receptor agonists on water drinking behaviour under thirsty conditions in mice with reduced dopamine secretion

Cutaneous pigmentation modulates skin sensitivity via tyrosinase-dependent dopaminergic signalling

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