Dopamine induces neutrophil apoptosis through a dopamine D-1 receptor–independent mechanism

Sookhai, S.; Wang, J.H.; McCourt, Morgan; O’Connell, Damian P.; Redmond, H. P.

doi:10.1016/s0039-6060(99)70171-6

Cited by 49 publications

(29 citation statements)

References 20 publications

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“…Therefore, we suggest that the paracrine cross-talk between Drd2 and the VEGF/VEGFR2 system and the additional effects exerted by quinagolide in the present study may be mediated by macrophages. In this regard, Drd2 activation in macrophages is known to increase their phagocytic activity (24). In addition, our PCR arrays revealed that PAI-1, a potent inhibitor of fibrinolysis, was the most down-regulated gene in L2 lesions.…”

Section: Lesion Size Before and After Quinagolide Treatmentmentioning

confidence: 70%

Effects of hyperprolactinemia treatment with the dopamine agonist quinagolide on endometriotic lesions in patients with endometriosis-associated hyperprolactinemia

Gómez¹,

Abad²,

Delgado³

et al. 2011

Fertility and Sterility

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Section: Lesion Size Before and After Quinagolide Treatmentmentioning

confidence: 70%

Effects of hyperprolactinemia treatment with the dopamine agonist quinagolide on endometriotic lesions in patients with endometriosis-associated hyperprolactinemia

Gómez¹,

Abad²,

Delgado³

et al. 2011

Fertility and Sterility

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“…Neutrophil apoptosis is known to be an important event in the maintenance of immune homeostasis [23]. However, immune complexes are detectable during mucosal inflammation, which can activate neutrophils and prolong apoptosis [24].…”

Section: Discussionmentioning

confidence: 99%

Adsorptive Depletion of Myeloid Lineage Leucocytes as Remission Induction Therapy in Patients with Ulcerative Colitis after Failure of First-Line Medications: Results from a Three-Year Real World, Clinical Practice

et al. 2017

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Background/Aims: In patients with active ulcerative colitis (UC), pharmacologics, although initially effective in most patients, are associated with refractoriness, loss of response or unfavourable side effects as additional morbidity factors. Depletion of myeloid lineage leucocytes like the CD14(+)CD16(+) monocyte phenotype, which is a major source of tumour necrosis factor-α, by granulocyte/monocyte apheresis (GMA) if effective, is also known to be free from side effects. Methods: In clinical practice setting, 77 consecutive patients with moderate to severe UC, who failed to respond to first-line medications received GMA with the Adacolumn as remission induction therapy. Patients who achieved remission were followed for 3 years. Results: Among the 77 patients, 46.8% were corticosteroids-naïve, 26% corticosteroid-dependent and 27.3% corticosteroid-refractory. The overall clinical remission rate was 79.2%, and the overall mucosal healing (MH) rate according to the Mayo endoscopic subscore ≤1 was 58.5%. MH rates incorticosteroid-naïve, corticosteroid-dependent and corticosteroid-refractory subgroups were 70.8, 56.3, and 38.5%, respectively. The 3-year sustained clinical remission rates in corticosteroid-naïve, corticosteroid-dependent and corticosteroid-refractory subgroups were 83.3, 68.8, and 23.1%, respectively. Conclusion: Corticosteroid-naïve patients appeared to benefit the most from the Adacolumn GMA, and attain a favourable long-term clinical course. Accordingly, GMA should be a first-line therapy in this clinical setting.

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“…107,151 Indeed, inflammation can stimulate angiogenesis: nutrients and oxygen are supplied from the formation of new vessels to allow the transport of inflammatory cells during inflammatory processes. Of note, changes in angiogenic and anti-angiogenic factors expression have been observed in patients with sepsis or those with localized infection.…”

Section: Discussionmentioning

confidence: 99%

Endoglin in Amniotic Fluid as a Risk Factor for the Subsequent Development of Bronchopulmonary Dysplasia

Kim

Romero

Savasan

et al. 2012

American J Rep Immunol

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Objective Cross-talk between inflammation and angiogenesis pathways has been recently reported. The objective of this study was to: 1) examine whether amniotic fluid (AF) concentrations of soluble endoglin (sEng), a protein with anti-angiogenic properties, changes during pregnancy, parturition or intraamniotic infection and/or inflammation (IAI); 2) determine whether an elevation of sEng in the AF of patients with preterm labor (PTL) and preterm prelabor rupture of membranes (PROM) is associated with adverse neonatal outcomes; and 3) investigate potential sources of sEng in AF. Study Design A cross-sectional study was conducted to include patients in the following groups: 1) midtrimester (n=20); 2) PTL with term delivery (n=95); 3) PTL leading to preterm delivery with (n=40) and without IAI (n=46); 4) preterm PROM with (n=37) and without IAI (n=37); 5) term in labor (n=48) and not in labor (n=44). AF concentrations of sEng were determined by ELISA. Chorioamniotic membranes, umbilical cord blood and AF macrophages were examined for the expression of endoglin. Results 1) Patients with IAI had a higher median AF concentration of sEng than those without IAI (p=0.02 for PTL; and 0.06 for preterm PROM); 2) AF concentrations of sEng in the 3rd and 4th quartiles were associated with IAI (OR 2.5 and 7.9 respectively); 3) an AF sEng concentration ≥779.5 pg/ml was associated with bronchopulmonary dysplasia (BPD) (OR 7.9); 4) endoglin was co-localized with CD14+ macrophages in AF pellets of patients with IAI by immunofluorescence and flow cytometry; and 5) the concentration of sEng in the supernatant was significantly increased after treatment of macrophages with endotoxin or TNF-α. Conclusions sEng participates in the host response against IAI. Activated macrophages may be a source of sEng concentrations in the AF of patients with IAI. An increase of sEng in the AF is associated with BPD and adverse neonatal outcomes.

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Dopamine induces neutrophil apoptosis through a dopamine D-1 receptor–independent mechanism

Cited by 49 publications

References 20 publications

Effects of hyperprolactinemia treatment with the dopamine agonist quinagolide on endometriotic lesions in patients with endometriosis-associated hyperprolactinemia

Effects of hyperprolactinemia treatment with the dopamine agonist quinagolide on endometriotic lesions in patients with endometriosis-associated hyperprolactinemia

Adsorptive Depletion of Myeloid Lineage Leucocytes as Remission Induction Therapy in Patients with Ulcerative Colitis after Failure of First-Line Medications: Results from a Three-Year Real World, Clinical Practice

Endoglin in Amniotic Fluid as a Risk Factor for the Subsequent Development of Bronchopulmonary Dysplasia

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