Dopamine in the Turkey Retina—An Impact of Environmental Light, Circadian Clock, and Melatonin

Lorenc-Duda, Anna; Berezińska, Małgorzata; Urbańska, Anna; Gołembiowska, Krystyna; Zawilska, Jolanta B.

doi:10.1007/s12031-008-9153-8

Cited by 10 publications

(7 citation statements)

References 44 publications

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“…The opposite effects of dark rearing on the b-/a-wave ratio of WT and D1−/− mice seem to be the result of a stronger reduction of b-wave of dark reared D1−/− mice, particularly the b-wave evoked by low intensity of lights. Because dopamine release in the retina is likely to be reduced in dark reared animals [56] – [58] , [101] – [104] , dark rearing would reduce the activation of D1 dopamine receptors in WT mice but not induce any D1 receptor mediated effects in D1−/− mice. The fact that dark rearing reduced the b-/a-wave ratio of D1−/− mice to the level of WT mice raised under the cyclic light conditions suggests that dopamine reduces the b-/a-wave ratio through activation of D1 dopamine receptors and enhances the b-/a-wave ratio through another mechanism.…”

Section: Discussionmentioning

confidence: 99%

Dopamine D1 Receptors Regulate the Light Dependent Development of Retinal Synaptic Responses

He¹,

Wang

et al. 2013

PLoS ONE

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Retinal synaptic connections and function are developmentally regulated. Retinal synaptic activity plays critical roles in the development of retinal synaptic circuitry. Dopamine receptors have been thought to play important roles in the activity-dependent synaptic plasticity in central nervous system. The primary goal of this study is to determine whether dopamine D1 receptor regulates the activity-dependent development of retinal light responsiveness. Accordingly, we recorded electroretinogram from wild type mice and mice with genetic deletion of D1 dopamine receptor (D1−/− mice) raised under cyclic light conditions and constant darkness. Our results demonstrated that D1−/− mice have reduced amplitudes of all three major components of electroretinogram in adulthood. When the relative strength of the responses is considered, the D1−/− mice have selective reduction of the amplitudes of a-wave and oscillatory potentials evoked by low-intermediate intensities of lights. During postnatal development, D1−/− mice have increased amplitude of b-wave at the time of eye-opening but reduced developmental increase of the amplitude of b-wave after eye opening. Light deprivation from birth significantly reduced the amplitudes of b-wave and oscillatory potentials, increased the outer retinal light response gain and altered the light response kinetics of both a- and b-waves of wild type mice. In D1−/− mice, the effect of dark rearing on the amplitude of oscillatory potentials was diminished and dark rearing induced effects on the response gain of outer retina and the kinetics of a-wave were reversed. These results demonstrated roles of dopamine D1 receptor in the activity-dependent functional development of mouse retina.

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Section: Discussionmentioning

confidence: 99%

Dopamine D1 Receptors Regulate the Light Dependent Development of Retinal Synaptic Responses

He¹,

Wang

et al. 2013

PLoS ONE

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“…Activation of D2 receptors regulates gap junction couplings between rods and cones, gap junction couplings between RGCs (Mills et al, 2007;Ribelayga & Mangel, 2010), transmembrane currents in rods (Kawai et al, 2011), the amplitudes of electroretinogram (ERG) b-waves (Miranda-Anaya et al, 2002) and oscillatory potentials (OPs) (Perry & George, 2007), and the light responses of RGCs (Bodis-Wollner & Tzelepi, 1998). In addition, development and visual activity regulates the expression of dopamine receptors, the number of dopaminergic cells (Melamed et al, 1986;Klitten et al, 2008), and the storage and release of dopamine (Melamed et al, 1986;Spira & Parkinson, 1991;Shelke et al, 1997;Lorenc-Duda et al, 2009). Therefore, it is highly likely that D2 receptors might also regulate the activity-dependent development of the retina.…”

Section: Introductionmentioning

confidence: 99%

Dopamine D2 receptors preferentially regulate the development of light responses of the inner retina

Tian

Wang

2014

Eur J of Neuroscience

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Retinal light responsiveness measured via electroretinography undergoes developmental modulation and is thought to be critically regulated by both visual experience and dopamine. The primary goal of this study is to determine whether the dopamine D2 receptor regulates the visual experience-dependent functional development of the retina. Accordingly, we recorded electroretinograms from wild type mice and mice with a genetic deletion of the gene that encodes the dopamine D2 receptor raised under normal cyclic light conditions and constant darkness. Our results demonstrate that mutation of the dopamine D2 receptors preferentially increases the amplitude of the inner retinal light responses evoked by high intensity light measured as oscillatory potentials in adult mice. During postnatal development, all three major components of electroretinograms, the a-wave, b-wave and oscillatory potentials, increase with age. Comparatively, mutation of the dopamine D2 receptors preferentially reduces the age-dependent increase of b-waves evoked by low intensity light. Light deprivation from birth reduces the amplitude of b-waves and completely diminishes the increased amplitude of oscillatory potentials. Taken together, these results demonstrate that the dopamine D2 receptor plays an important role in the activity-dependent functional development of the mouse retina.

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“…Light is one of the important environmental factors affecting crustaceans’ survival, directly or indirectly influencing their growth, feeding and reproduction[ 13 , 46 , 47 ], and light environment is the major factor regulating the synthesis and metabolism of dopamine[ 16 ]. As a benthic animal, the Chinese mitten crab prefers a dark environment, and planting waterweed can have a shading and cooling effect that is beneficial to growth and survival[ 48 ].…”

Section: Discussionmentioning

confidence: 99%

“…Light influences the growth and development of crustaceans[ 12 , 13 ], such as Macrobrachium rosenbergii and Portunus pelagicus , and daily changes in dopamine synthesis and release depend on the interactions between the photoreceptors and the dopaminergic neurons, where dopamine release is induced by light[ 14 , 15 ]. High levels of dopamine have been detected during light periods and low levels during dark periods[ 16 – 18 ], for this reason, it is believed that dopamine promotes light adaptation. However, constant light results in a dramatic reduction in dopamine levels in chicken retina[ 19 ].…”

Section: Introductionmentioning

confidence: 99%

Cloning and functional characterization of the DA2 receptor gene in Chinese mitten crab (Eriocheir sinensis)

Yang

Huang

et al. 2018

PLoS ONE

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Dopamine (DA) plays a modulatory role in numerous physiological processes such as light adaptation and food intake, and exerts these functions through DA receptors (DARs). This study presents, for the first time, isolation and characterization of the dopamine receptor 2(DA2 receptor) cDNA from the intestinal tissue of Eriocheir sinensis, an economically important freshwater aquaculture species in China. The DA2 receptor cDNA sequence, which was obtained by rapid amplification of cDNA ends, is 2369bp long, encode peptide of 589 amino acid, and is highly homologous to related sequences in crustaceans. Analysis of the deduced amino acid sequence and the structure of the DA2 indicated that this receptor is a member of the family of G protein-coupled receptors (GPCRs), as it contains seven transmembrane domains and other common signatures of GPCRs. RT-PCR showed that the expression of the DA2 receptor gene was distributed in various tissues, and high expression levels were observed in the cranial ganglia and the thoracic ganglia. Further study of the effect of photoperiod on DA2 expression showed that constant darkness induced a significant increase in DA2 expression in the cranial ganglia. Finally, analysis of DA2 receptor expression under different feeding statuses showed that there was significantly greater expression in the hepatopancreas and intestines after feeding than before feeding, but there were no differences in expression between the before feeding and during feeding periods in either tissue. Our results indicate that the DA2 receptor structurally belongs to the family of G protein-coupled receptors, and that the cranial ganglia are the main tissues in which the DA2 receptor participates in light adaptation during dark hours. In addition, the DA2 receptor in E. sinensis may be involved in the physiological regulation of the hepatopancreas and digestive tract after the ingestion of food. This study provides a foundation for further exploration of the light adaptation and digestive functions of the DA2 receptor in decapods.

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Dopamine in the Turkey Retina—An Impact of Environmental Light, Circadian Clock, and Melatonin

Cited by 10 publications

References 44 publications

Dopamine D1 Receptors Regulate the Light Dependent Development of Retinal Synaptic Responses

Dopamine D1 Receptors Regulate the Light Dependent Development of Retinal Synaptic Responses

Dopamine D2 receptors preferentially regulate the development of light responses of the inner retina

Cloning and functional characterization of the DA2 receptor gene in Chinese mitten crab (Eriocheir sinensis)

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