“Dopamine homeostasis” requires balanced polypharmacy: Issue with destructive, powerful dopamine agents to combat America’s drug epidemic

Abstract

The well-researched pro-dopamine regulator KB220 and variants result in increased functional connectivity in both animal and human brains, and prolonged neuroplasticity (brain cell repair) having been observed in rodents. Moreover, in addition to increased functional connectivity, recent studies show that KB220Z increases overall brain connectivity volume, enhances neuronal dopamine firing, and eliminates lucid dreams in humans over a prolonged period. An unprecedented number of clinical studies validating this patented nutrigenomic technology in re-balancing brain chemistry and optimizing dopamine sensitivity and function have been published. On another note, it is sad that unsuspecting consumers could be deceived and endangered by false promises of knock-off marketers with look- and- sound-alike products. Products containing ingredients having potential dangers (i.e., combinations of potent D2 agonists including L-Dopa and L-Theanine) threaten the credibility and reputation of validated, authentic, and ethical products. We encourage clinicians and neuroscientists to continue to embrace the concept of “dopamine homeostasis” and search for safe, effective, validated and authentic means to achieve a lifetime of recovery, instead of reverting to anti-dopaminergic agents doomed to fail in the war against the devastating drug epidemic, or promoting powerful D2 agonists that compromise needed balance.

Introducing Precision Addiction Management of Reward Deficiency Syndrome, the Construct That Underpins All Addictive Behaviors

“…Here clinicians and neuroscientists are encouraged to continue to embrace the concept of “dopamine homeostasis” and search for safe, effective, validated and authentic means to achieve a lifetime of recovery, instead of reverting to anti-dopaminergic agents. Anti-dopaminergic agents are doomed to fail because chronic use continues and exacerbates hypodopaminergia while promoting powerful D2 agonists like bromocriptine and L-Dopa compromises needed balance ( 36 ). Increased resting state functional connectivity as well as an increased neuronal recruitment has been demonstrated acutely on fMRI in both animal and humans within 15 (animal) to 60 (human) minutes post administration of neuro nutrient therapy.…”

An Iron-Free VMP35 Multi-nutrient Complex Modulates an Array of Homeostatic Biological Parameters: Promoting Hemoglobinization, Aerobic Metabolism, Viral Immuno-competence, and Inflammatory Regulation

“…Optimizing the ideal pH in the blood is the result of the compensatory homeostatic exchange of acid and alkaline pH buffers. A pH of the blood below 7.35 is acidemia, while a pH above 7.45 is alkalemia, with a pH of 7.40 being ideal [59][60][61][62][64][65][66][67][68]. Due to the importance of sustaining a pH level in the narrow speci ed range, the human body exerts a compensatory mechanistic acid/alkaline exchange via Homeostatic Counterbalancing [64][65][66][67][68].…”

“…A progressive inability of cells to effectively use cellular oxygen leads to Progressive Acidemia, a metabolic shift toward cellular anaerobic glycolysis, and a compensatory expenditure of alkalinizing histidine molecules from the heme protein of deconjugated hemoglobin, which releases iron. Iron is taken out of circulation and accumulates in the liver, bone marrow, and other organs, which appears to be iron de cient anemia ('IDA') but can result in dangerous accumulations of iron in the various tissue storage depots [9,10,67,68]. Our group suggests that ACD and IDA have been misconceptualized and asserts that Chronic Anemia Syndrome (CAS) is a more appropriate and accurate descriptor for the anaerobic/hypoxic conditions inducing chronic disease pathologies.…”

“…cross talk) and neuroplasticity of brain cells are impaired; among other consequences. This type of impairment can exacerbate and/or lead to excessive reward-seeking thoughts and behavioral disorders such as ADD, ADHD, Obstinate De ance Disorder (ODD), hypersexuality, substance use disorder (SUD), dementia, tics, Tourette's, Parkinson's Disease, sleep disorders and vivid nightmares, depression; obsessive, compulsive, impulsive and addictive behaviors; autism spectrum disorder, intermittent explosive disorder, bipolar disorder, uncontrolled cravings, extreme self-medicating behaviors, stress intolerance, fatigue, relapse, and poor decision making, among many others types of RDS behaviors[9,10,67,68].…”

Would induction of dopamine homeostasis via coupling genetic addiction risk score (GARS®) and pro-dopamine regulation benefit benzodiazepine use disorder (BUD)

“…Importantly, while it is widely accepted that dopamine is a major neurotransmitter implicated in behavioral and substance addictions, including BUD, there remains controversy about how to modulate dopamine clinically. One important question relates to genetic antecedents of hypodopaminergia, placing people at high risk for all addictive behaviors including BUD [61]. We believe that early genetic identification of hypodopaminergia could translate to early intervention.…”