Dopamine delays gastric emptying and prolongs orocaecal transit time in volunteers

Levein, N. G.; Thörn, Sven‐Egron; Wattwil, Magnus

doi:10.1046/j.1365-2346.1999.00471.x

Cited by 31 publications

(9 citation statements)

References 17 publications

(22 reference statements)

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“…37,38 Dopamine is known to reduce antral contractions, shorten MMC duration 39 and slow GE and orocaecal transit. 40 However, dopamine was not administered to patients in this study and it is unclear whether these effects occur with other catecholamines. Ageing is also associated with a small but measurable slowing of GE.…”

Section: Discussionmentioning

confidence: 93%

Gastric emptying and the organization of antro‐duodenal pressures in the critically ill

Chapman

Fraser

Bryant

et al. 2007

Neurogastroenterology Motil

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The motor dysfunctions underlying delayed gastric emptying (GE) in critical illness are poorly defined. Our aim was to characterize the relationship between antro-duodenal (AD) motility and GE in critically ill patients. AD pressures were recorded in 15 mechanically ventilated patients and 10 healthy volunteers for 2 h (i) during fasting, (ii) following an intragastric nutrient bolus with concurrent assessment of GE using the (13)C-octanoate breath test and (iii) during duodenal nutrient infusion. Propagated waves were characterized by length and direction of migration. Critical illness was associated with: (i) slower GE (GEC: 3.47 +/- 0.1 vs 2.99 +/- 0.2; P = 0.046), (ii) fewer antegrade (duodenal: 44%vs 83%, AD: 16%vs 83%; P < 0.001) and more retrograde (duodenal: 46%vs 12%, AD: 38%vs 4%; P < 0.001) waves, (iii) shorter wave propagation (duodenal: 4.7 +/- 0.3 vs 6.0 +/- 0.4 cm; AD: 7.7 +/- 0.6 vs 10.9 +/- 0.9 cm; P = 0.004) and (iv) a close correlation between GE with the percentage of propagated phase 3 waves that were antegrade (r = 0.914, P = 0.03) and retrograde (r = -0.95, P = 0.014). In critical illness, the organization of AD pressure waves is abnormal and associated with slow GE.

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Section: Discussionmentioning

confidence: 93%

Gastric emptying and the organization of antro‐duodenal pressures in the critically ill

Chapman

Fraser

Bryant

et al. 2007

Neurogastroenterology Motil

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“…Rationale. Dopamine inhibits acetylcholine release and gastric motility and it has been proposed as a possible neurotransmitter in gastric relaxation [ 64 , 65 ]. The effect of dopamine has been thought to be mediated through the dopamine-2 receptor and dopamine-3 receptor [ 65 ].…”

Section: Drug Administration Animal Modelsmentioning

confidence: 99%

Choosing an Animal Model for the Study of Functional Dyspepsia

Wang

Zheng

et al. 2018

Canadian Journal of Gastroenterology and Hepatology

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Functional dyspepsia (FD) is a common functional gastrointestinal disorder with pain or discomfort in the upper abdomen as the main characteristic. The prevalence of FD worldwide varies between 5% and 11%. This condition adversely affects attendance and productivity in the workplace. Emerging evidence is beginning to unravel the pathophysiologies of FD, and new data on treatment are helping to guide evidence-based practice. In order to better understand the pathophysiologies of FD and explore better treatment options, various kinds of animal models of FD have been developed. However, it is unclear which of these models most closely mimic the human disease. This review provides a comprehensive overview of the currently available animal models of FD in relationship to the clinical features of the disease. The rationales, methods, merits, and disadvantages for modelling specific symptoms of FD are discussed in detail.

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“…All breath samples were analyzed for 13 CO 2 using an infrared (IR) spectrophotometer (Otsuka Electronics Inc., Tokyo, Japan). [13]C is a safe, naturally-occurring isotope. The principle of the breath test is that ingestion of a liquid test meal containing 13 C-acetate results in slower or faster gastric emptying, absorption from the digestive tract, metabolism in the liver (production of 13 CO 2 ), expiration from the lung, and increase of 13 CO 2 in expired breath.…”

Section: Methodsmentioning

confidence: 99%

“…Previously, drugs that act on myenteric dopamine 14 or 5-hydroxytryptamine [5-HT, serotonin] receptors 15 have been used to treat delayed gastric emptying in PD, showing variable benefits. The purpose of this study is to present the results of our 13 C-sodium acetate expiration breath analyses before and after administration of nizatidine (NZT) that acts on histamine H2-receptors 16 in patients with PD.…”

mentioning

confidence: 99%