Dopamine deficiency in the cerebral cortex in Parkinson disease

Scatton, B.; Rouquier, L.; Javoy‐Agid, F.; Agid, Yves

doi:10.1212/wnl.32.9.1039

Cited by 176 publications

(51 citation statements)

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“…Our observations are in accordance with postmortem studies that have reported only mild depletion of DA in the prefrontal cortex in PD. 31,32 Studies in vivo with 18 F-dopa PET also have shown either a small decline 33 or no changes in prefrontal tracer uptake in advanced PD patients in comparison with controls. 20 Prefrontal deficits of executive functions, such as planning and spatial working memory, have been reported in PD 34 -36 even early in the disease process.…”

Section: Discussionmentioning

confidence: 99%

Endogenous dopamine release after pharmacological challenges in Parkinson's disease

Piccini

Pavese

Brooks

2003

Annals of Neurology

144

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Using (11)C-raclopride positron emission tomography after methamphetamine challenge, we have evaluated regional brain changes in synaptic dopamine (DA) levels in six volunteers and six advanced Parkinson's disease (PD) patients. The pharmacological challenge induced significant release of endogenous DA in putamen not only in the normal subjects, as reflected by a 25.2% reduction in (11)C-raclopride binding potential as compared with placebo, but also in the PD patients (6.8%). In individual PD patients, we found a correlation between putamen DA release and DA storage, as measured by (18)F-dopa uptake. Localization of significant changes in (11)C-raclopride binding after methamphetamine at a voxel level with statistical parametric mapping identified striatal and prefrontal DA release in both cohorts. Statistical comparisons between normal subjects and PD confirmed significantly reduced DA release in striatal areas in PD, but normal levels of prefrontal DA release. In conclusion, significant endogenous DA release can still be induced by pharmacological challenges in the putamen of advanced PD patients, and this release correlates with residual DA storage capacity. Our data also show that the capacity to release normal DA levels in prefrontal areas after a pharmacological challenge is preserved in severe stages of the disease.

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Section: Discussionmentioning

confidence: 99%

Endogenous dopamine release after pharmacological challenges in Parkinson's disease

Piccini

Pavese

Brooks

2003

Annals of Neurology

144

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“…Six-hydroxydopamine lesions within the principal sulcus, for example, produce deficits in monkeys performing working memory tasks comparable to surgical lesions (Brozoski et al, 1979), while local infusion of selective dopamine antagonists disrupts performance in oculomotor delayed response tasks Goldman-Rakic, 1991, 1994). In man, hypoactivity of prefrontal dopamine has also been linked to cognitive disturbances in schizophrenia and Parkinson's disease, including substandard performance on frontal lobe tasks such as the Wisconsin Card Sorting Test (e.g., Scatton et al, 1982;Weinberger, 1987;Goldman-Rakic, 1991). Dopamine levels also drop sharply and, among catecholamines, with some selectivity in the prefrontal cortex of aged primates (Goldman-Rakic and Brown, 1981).…”

Section: Indexing Terms: Schizophrenia; Association Cortex; Estrogen;mentioning

confidence: 99%

Ovarian hormones influence the morphology, distribution, and density of tyrosine hydroxylase immunoreactive axons in the dorsolateral prefrontal cortex of adult Rhesus monkeys

1998

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The maturation, adult functioning and dysfunction of the prefrontal cortex in disorders such as schizophrenia show gender biases in human and non-human primates. Although the basis for the hormone influence suggested in these observations is unknown, one possibility is that circulating hormones stimulate catecholamine innervation in the frontal lobe. This innervation is essential for prefrontal cortical function, and gonadal, especially ovarian hormones, profoundly influence catecholamine function and physiology in subcortical structures. This study was undertaken to determine whether influence is also exerted upon the catecholamine innervation of the association cortex by combining ovarian hormone manipulation with immunocytochemistry for tyrosine hydroxylase in the dorsolateral prefrontal cortex of adult female macaque monkeys. Qualitative and quantitative analyses of immunoreactive fibers were carried out and compared in cortices of ovariectomized animals, ovariectomized animals treated with estrogen, ovariectomized animals treated with estrogen followed by progesterone, and in intact, age- and sex-matched controls. These analyses revealed striking, layer-specific anomalies in fiber morphology and profound reductions in fiber density in ovariectomized animals. While hormone replacement with estrogen alone had limited influence, estrogen followed by progesterone was particularly effective in restoring tyrosine hydroxylase innervation in ovariectomized animals. Thus, ovarian hormones appear to be potent regulators of the catecholamine innervation of the primate prefrontal cortex. Such regulation is anticipated in the gender differences observed in prefrontal cortical development and function, and may also be relevant for the prefrontal dysfunction in disorders such as schizophrenia.

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“…PD's signature lesion is loss of neurons in the pars compacta of the substantia nigra and consequent dopamine depletion in the striatum (49). In addition, there is damage to the mesocortical dopaminergic projection from the ventral tegmental area to the frontal lobes (50,51). PD patients in even the earliest stages of the disease exhibit a pattern of intact and impaired cognition and memory that is strikingly similar to that shown by patients with frontal-lobe lesions (reviewed in ref.…”

Section: Pd and Strategic Memorymentioning

confidence: 99%

Memory systems analyses of mnemonic disorders in aging and age-related diseases

Gabrieli

1996

Proc. Natl. Acad. Sci. U.S.A.

105

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The effects upon memory of normal aging and two age-related neurodegenerative diseases, Alzheimer disease (AD) and Parkinson disease, are analyzed in terms of memory systems, specific neural networks that mediate specific mnemonic processes. An occipital memory system mediating implicit visual-perceptual memory appears to be unaffected by aging or AD. A frontal system that may mediate implicit conceptual memory is affected by AD but not by normal aging. Another frontal system that mediates aspects of working and strategic memory is affected by Parkinson disease and, to a lesser extent, by aging. The aging effect appears to occur during all ages of the adult life-span. Finally, a medial-temporal system that mediates declarative memory is affected by the late onset of AD. Studies of intact and impaired memory in age-related diseases suggest that normal aging has markedly different effects upon different memory systems.A major goal of cognitive neuroscience is to identify and characterize memory systems of the human brain, which are specific neural networks that mediate specific mnemonic processes. One purpose is to provide an accurate and comprehensive understanding of the functional neural architecture of human memory. A second purpose is to understand how acute or degenerative injuries to particular systems result in particular memory disabilities. These two purposes are intertwined in research because, historically, identification and characterization of human memory systems has occurred through clinical and experimental evaluations of patients with focal brain lesions. More recently, functional neuroimaging has provided new views of the memory systems that record, retain, and retrieve various forms of experience.The modern study of memory systems began in the 1950s with the appreciation of the brain-behavior relations underlying global amnesia, a neurological syndrome characterized by a deficit in learning new information that does not appear to be secondary to any other behavioral incapacity

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Dopamine deficiency in the cerebral cortex in Parkinson disease

Cited by 176 publications

References 0 publications

Endogenous dopamine release after pharmacological challenges in Parkinson's disease

Endogenous dopamine release after pharmacological challenges in Parkinson's disease

Ovarian hormones influence the morphology, distribution, and density of tyrosine hydroxylase immunoreactive axons in the dorsolateral prefrontal cortex of adult Rhesus monkeys

Memory systems analyses of mnemonic disorders in aging and age-related diseases

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