Dopamine decreases release of luteinizing hormone releasing hormone from superfused rat mediobasal hypothalamus

Tasaka, Keiichi; Miyake, Akira; Sakumoto, Tetsuro; Aono, Toshihiro

doi:10.1007/bf03348517

Cited by 18 publications

(8 citation statements)

References 18 publications

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“…These results are consistent with the hypothesis that dopaminergic system is one of the main inhibitory neuronal systems that control the development of the reproductive systems (Becu-Villalobos and Libertun, 1995) and productivity (Sotowska-Brochocka et al, 1994). In rodents, the biological functions of DA on productivity had been confirmed by administrating exogenous DA that significantly reduced the LHRH level from the hypothalamus and lowered LH secretion from the pituitary (Tasaka et al, 1985). Provided studies had shown that endogenous DA secreted in the hypothalamus exhibited catecholamine's tonic inhibition of Luteinising hormone-releasing hormone (LHRH) release (Contijoch et al, 1992) and suppression LH secretion (Martin et al, 1981).…”

Section: Dopamine and Selection For High Productivity And Longevity Wsupporting

confidence: 88%

“…In rodents, the biological functions of DA on productivity had been confirmed by administrating exogenous DA that significantly reduced the LHRH level from the hypothalamus and lowered LH secretion from the pituitary (Tasaka et al, 1985). The later had been verified by either administrating of DA receptor agonist 2-Br-alpha-ergocryptine to lower plasma LH levels (Owens et al, 1980) or blocking DA inhibitory effect by use of DA receptor blocker halperidol (Tasaka et al, 1985). In hens, increase in dopaminergic activity inhibited the release of LH by exerting an inhibitory influence on the LHRH containing cells in the hypothalamus (Macnamee and Sharp 1989).…”

Section: Dopamine and Selection For High Productivity And Longevity Wmentioning

confidence: 99%

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Mechanisms of aggression and production in chickens: genetic variations in the functions of serotonin, catecholamine, and corticosterone

Cheng

Muir

2007

World's Poultry Science Journal

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The neuroendocrine systems, such as dopamine (DA) and serotonin (5-HT) as well as corticosterone (CORT), are involved in regulating behavioural patterns and reproduction in humans and other mammals. Similar functions of neuroendocrine system may present in laying hens. To test the hypothesis, two divergent chicken lines were used in the study. Each line has distinct levels of aggressiveness and productivity at a group setting and exhibits differen susceptibility to various environmental stressors. We found that, at 21 wks of age, LGPS (Low Group Productivity and Survivability) birds had significantly higher blood concentrations of DA and epinephrine than the KGB birds (Kind Gentle Birds, also previously termed HGPS, birds with a High Group Productivity and Survivability) (P<0.01, respectively). The blood concentration of norepinephrine was not significantly different between the lines but the ratio of epinephrine to norepinephrine was higher in LGPS birds (P<0.01). The blood concentration of 5-HT was also significantly higher in LGPS birds compared to KGB birds (P<0.01). In contrast, KGB birds tended to have a higher level of blood CORT (P=0.1). The results suggest that genetic selection for productivity and survivability with domestic behaviours alters the birds' neuroendocrine homeostasis. The selection-associated plasticity of the neuroendocrine system in controlling animal aggression and productivity were discussed in the article.Abbreviation Key: CNS = Central nervous system; CORT = Corticosterone; DA = Dopamine; DβH = Dopamine-β-hydroxylase; EP = epinephrine; DXL = Commercial Dekalb XL line; HA line = chicken line selected for high antibody response to SRBC; HAP axis = Hypothalamic-pituitary-adrenal axis; H:L = Heterophil:lymphocyte ratio; KGB = Kinder Gentler Bird selected for high group productivity and longevity; LA line = chicken line selected for high antibody response to SRBC; LH = luteinising hormone; LHRH = luteinising hormone-releasing hormone; LGPS = chicken line selected for low group productivity and survivability; MHC = Major histocompatibility complex; NE = norepinephrine; RIA = radioimmunoassay; SRBC = Sheep red blood cell; TH = tyrosine effects of selection on behavioural adaptation and productivity could lead to selectionassociated functional alterations of the neuroendocrine systems in releasing endogenous psychotropic compounds, such as 5-HT, DA, and CORT; and to evaluate whether the changes of these monoamines and CORT an be used as physiological indicators of an animal's coping ability and well-being. Material and methods DEVELOPMENT OF THE GENETIC LINESThe process for developing the genetic lines, KGB and LGPS, has been described previously (Muir, 1996; Cheng and Muir, 2005). Briefly, a programme termed "group selection" was used for developing the research lines. The programme turns "survival of the fittest" emphasized on the individuals to "survival of the adequate" in the group. Results from group selection studies have showed that productivity can be increase while at the same time...

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Section: Dopamine and Selection For High Productivity And Longevity Wsupporting

confidence: 88%

Section: Dopamine and Selection For High Productivity And Longevity Wmentioning

confidence: 99%

Mechanisms of aggression and production in chickens: genetic variations in the functions of serotonin, catecholamine, and corticosterone

Cheng

Muir

2007

World's Poultry Science Journal

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“…However, the mechanisms underlying dopaminergic regulation of gonadotropic hormone release remain unclear, particularly in fish. Previous studies demonstrate that in tetrapods, dopamine inhibits GnRH1 release (Ching and Lin, 1994;Lacau-Mengido et al, 1993;Owens et al, 1980;Tasaka et al, 1985) via actions at both the hypothalamic soma of GnRH1 neurons and their synaptic terminals within the portal vasculature (Contijoch et al, 1992;Corio et al, 1990;Kuljis and Advis, 1989;Lehman et al, 1988;Pehrson et al, 1983;Ugrumov et al, 1989). In fish, dopamine was thought to act primarily within the pituitary, reducing gonadotropin release either indirectly, by suppressing GnRH1-releasing axons, or directly, by inhibiting pituitary gonadotropes (Levavi-Sivan et al, 1995;Vacher et al, 2002;Van Goor et al, 1998;Yu and Peter, 1992;Yu et al, 1991).…”

Section: Introductionmentioning

confidence: 99%

Dopaminergic inhibition of gonadotropin-releasing hormone neurons in the cichlid fish,Astatotilapia burtoni

Bryant

Greenwood

Juntti

et al. 2016

Journal of Experimental Biology

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Dopamine regulates reproduction in part by modulating neuronal activity within the hypothalamic-pituitary-gonadal (HPG) axis. Previous studies suggested numerous mechanisms by which dopamine exerts inhibitory control over the HPG axis, ultimately changing the levels of sex steroids that regulate reproductive behaviors. However, it is not known whether these mechanisms are conserved across vertebrate species. In particular, it is unknown whether mechanisms underlying dopaminergic control of reproduction are shared between mammals and teleost fish. In mammals, dopamine directly inhibits gonadotropin-releasing hormone (GnRH1) hypothalamic neurons, the gatekeepers for activation of the HPG axis. Here, we demonstrate, for the first time in teleost fish, dopaminergic control of GnRH1 neurons via direct dopamine type-2-like receptor (D2R)-mediated inhibition within the hypothalamus. These results suggest that direct dopaminergic control of GnRH1 neurons via interactions in the hypothalamus is not exclusive to tetrapod reproductive control, but is likely conserved across vertebrate species.

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“…Despite conclusive evidences of the importance of catecholaminergic influences in the control of hypothalamic LHRH secretion (1 S), the role of dopamine in the functional control of the LHRH secreting neuron remains controversial. Evidence exists to support a stimulatory and/or and inhibitory role of dopamine in the maintenance of LHRH secretion (1 3, 14, [16][17][18][19][20][21]37). In adult rats the mechanism of dopamine induced stimulation of LHRH efflux from the medium basal hypothalamus perifused in vitro is probably attributable to the action of dopamine in causing release of endogenous noradrenaline (14); and dopamine inhibition of LHRH release from medium basal hypothalami is apparently achieved by increasing endogenous opioid activity (18).…”

Section: Discussionmentioning

confidence: 99%

Antidopaminergic‐lnduced Hypothalamic LHRH Release and Pituitary Gonadotrophin Secretion in 12 Day‐Old Female and Male Rats

Lacau-Mengido

Becú-Villalobos

Thyssen

et al. 1993

J Neuroendocrinology

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In previous studies we have shown that the developing rat provides an interesting physiologic model in which the dopaminergic control of both LH and FSH is well defined in contrast to the controversial results obtained in adult rats. We wished to establish the role of testosterone in antidopaminergic induced gonadotrophins release in 12 day-old male and female rats, and evaluate the effect of antidopaminergic drugs at the hypothalamic level during this developmental stage. Haloperidol, an antidopaminergic drug, increased both LH and FSH in female 12 day-old rats but not in male littermates. The effect was blocked by bromocriptine and not by phentolamine indicating that haloperidol acted on the dopaminergic receptor, and that unspecific stimulation of the noradrenergic system was not involved. Haloperidol was ineffective when female rats were previously ovariectomized and injected with testosterone propionate at 9 days of age. If females were treated on the day of birth with testosterone propionate, haloperidol-induced FSH and LH release was also abolished. In control males haloperidol had no effect on the release of LH or FSH. But if males were orchidectomized at birth or at 9 days of age, haloperidol released both LH and FSH during the infantile period. In an attempt to establish the site of action of antidopaminergic drugs on gonadotrophin release, hypothalami (mediobasal and preoptic-suprachiasmatic area) from 12 day-old infant female rats were perifused with either haloperidol or domperidone (2*10(-6) M). Both drugs increased LHRH release into the perifusate. Besides haloperidol did not modify the release of LH or FSH from adenohypophyseal cells incubated in vitro. We therefore conclude that antidopaminergic-induced gonadotrophins release is modulated by serum testosterone concentrations, and that the site of action is probably the LHRH-secreting neuron of the hypothalamus.

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Dopamine decreases release of luteinizing hormone releasing hormone from superfused rat mediobasal hypothalamus

Cited by 18 publications

References 18 publications

Mechanisms of aggression and production in chickens: genetic variations in the functions of serotonin, catecholamine, and corticosterone

Mechanisms of aggression and production in chickens: genetic variations in the functions of serotonin, catecholamine, and corticosterone

Dopaminergic inhibition of gonadotropin-releasing hormone neurons in the cichlid fish,Astatotilapia burtoni

Antidopaminergic‐lnduced Hypothalamic LHRH Release and Pituitary Gonadotrophin Secretion in 12 Day‐Old Female and Male Rats

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