Dopamine D4 receptor gene exon III polymorphism associated with binge drinking attitudinal phenotype

Vaughn, Michael G.; Beaver, Kevin M.; DeLisi, Matt; Howard, Matthew O.; Perron, Brian E.

doi:10.1016/j.alcohol.2009.02.001

Cited by 23 publications

(18 citation statements)

References 29 publications

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“…It could be that marijuana use is an activity youth engage in to cope with the negative environmental stressors as suggested by the PBT. However, unlike previous research (Kilpatrick et al, 2000;Vaughn et al, 2009), the environment system variable (i.e., exposure to delinquent peers) was not related to the annual frequency of marijuana use. Although this observation does not lend support to the PBT, it is important FIGURE 1.…”

Section: Discussioncontrasting

confidence: 82%

“…Moreover, research has established a direct relationship between exposure to delinquent peers and substance use, including marijuana, in adolescents (Kilpatrick et al, 2000;Vaughn, Beaver, DeLisi, Howard, & Perron, 2009). Specifically, drug-using peers have been found to represent a strong correlate of drug experimentation.…”

Section: The Environmental Factors and Marijuana Usementioning

confidence: 98%

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Individual and Peer Correlates of the Annual Frequency of Marijuana Use Among African American Adolescents Living in US Urban Public Housing Neighborhoods

Nebbitt

Lombe

et al. 2013

Substance Use & Misuse

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Marijuana is the most commonly used illegal drug in the United States. Urban minority youth reports the highest consumption. Using a sample of 550 African American youth living in public housing located in three large Northeastern US cities, this article examines individual and peer correlates of the annual frequency of marijuana use. Data were collected between the Fall of 2007 and the Spring of 2008. The sample reported a mean age of 15 with 48% being female. Pearson's bivariate correlation and sequential regression analysis were conducted. The model explained 35% of the variance. Limitations and implications are discussed.

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Section: Discussioncontrasting

confidence: 82%

Section: The Environmental Factors and Marijuana Usementioning

confidence: 98%

Individual and Peer Correlates of the Annual Frequency of Marijuana Use Among African American Adolescents Living in US Urban Public Housing Neighborhoods

Nebbitt

Lombe

et al. 2013

Substance Use & Misuse

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“…Other studies have suggested that long repeats may interact with polymorphisms at other sites such as DRD2 (Beaver et al, 2007;Boutwell & Beaver, 2008) and DAT (Congdon, Lesch, & Canli, 2008) in impulsivity or disruptive behavior disorders. Still other lines of research point to long repeats in binge drinking, smoking, and novelty seeking (Laucht, Becker, El-Faddagh, Hohm, & Schmidt, 2005;Ray, MacKillop, McGeary, Hesterberg, & Hutchinson, 2009;Vaughn, Beaver, DeLisi, & Perron, 2009). Table 4 provides an overview of the recent studies cited above, ordered primarily by site, and then by year and first author.…”

Section: Dopamine Receptorsmentioning

confidence: 95%

Behavioral genetics in antisocial spectrum disorders and psychopathy: A review of the recent literature

Gunter

Vaughn

Philibert

2010

Behavioral Sci & The Law

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Behavioral geneticists are increasingly using the tools of molecular genetics to extend upon discoveries from twin, family, and adoption studies concerning the heritability of antisocial spectrum disorders and psychopathy. While there is a substantial body of research concerning antisocial spectrum disorders in the behavioral genetics literature, only a few studies could be located using the phenotype of psychopathy. In this report we summarize some of the recent molecular genetics work concerning antisocial spectrum disorders and psychopathy, with a focus on genes involved in the serotonergic and dopaminergic pathways, while also mentioning some of the novel genetic factors being considered. Monoamine oxidase (MAOA) and the serotonin transporter (5HTT) are reviewed at length, as these genes have received significant scientific attention in recent years and are sites of high biological plausibility in antisocial spectrum disorders and psychopathy.

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“…One genetic polymorphism of interest in the alcoholism literature is the number of variable number tandem repeats (VNTR) in the third exon of the DRD4 dopamine receptor gene. The presence of a long DRD4 allele (involving 7+ repeats) decreases dopamine reception efficiency (Asghari et al, 1995) and has been linked with increased craving in response to alcohol cues (McGeary, 2009; Ray et al, 2010), greater alcohol use (Vaughn et al, 2009), and personality correlates of alcohol use such as thrill seeking (Dmitrieva et al, 2011), as well as other types of problem and addictive behaviors such as delinquency (Boutwell and Beaver, 2008) and smoking (Hutchison et al, 2002). This study examines the interaction of DRD4 polymorphism with a key environmental factor in alcohol use – peer drinking (Windle, 2000), across several developmental periods from adolescence through young adulthood.…”

Section: Introductionmentioning

confidence: 99%

DRD4 and susceptibility to peer influence on alcohol use from adolescence to adulthood

Mrug

Windle

2014

Drug and Alcohol Dependence

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Background The long allele of DRD4 is associated with greater susceptibility to peer influences on alcohol use in young adulthood, but it is unclear whether this increased susceptibility extends to other developmental periods. This study examined the interactive effects of DRD4 polymorphism and friends' alcohol use from adolescence to adulthood. Methods Participants (N=340; 59% female; 98% White) reported on their own and their friends' alcohol use at four time points between mean ages 17 and 33. Autoregressive cross-lagged models evaluated reciprocal relationships between friends' alcohol use and participants' own alcohol use and frequency of heavy drinking over time. Multigroup modeling tested differences in model paths and covariances across high vs. low risk DRD4 polymorphisms. Results Alcohol use at age 33 was predicted by previous friends' alcohol use and correlated with current friends' alcohol use only for carriers of the DRD4 long allele. Regardless of DRD4 genotype, friends' alcohol use at age 17 predicted greater alcohol use and more frequent heavy drinking at age 23. Alcohol use and/or heavy drinking predicted greater friends' alcohol use at later time points for both genotype groups across adolescence and adulthood. Conclusions The long allele of DRD4 is associated with increased susceptibility to peer influences on alcohol use in young adulthood, but not earlier in development. Adults with the long allele of DRD4 may benefit from interventions educating them about this risk and equipping them with strategies to reduce affiliations with and influence of drinking friends.

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Dopamine D4 receptor gene exon III polymorphism associated with binge drinking attitudinal phenotype

Cited by 23 publications

References 29 publications

Individual and Peer Correlates of the Annual Frequency of Marijuana Use Among African American Adolescents Living in US Urban Public Housing Neighborhoods

Individual and Peer Correlates of the Annual Frequency of Marijuana Use Among African American Adolescents Living in US Urban Public Housing Neighborhoods

Behavioral genetics in antisocial spectrum disorders and psychopathy: A review of the recent literature

DRD4 and susceptibility to peer influence on alcohol use from adolescence to adulthood

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