Dopamine D2 receptor mediated presynaptic inhibition of striatopallidal GABAA IPSCs in vitro

Cooper, Alexandra; Stanford, Ian M.

doi:10.1016/s0028-3908(01)00038-7

Cited by 137 publications

(124 citation statements)

References 44 publications

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“…If that were true, a consistent dopaminergic modulation should be seen, which was the case, resulting in the initial description of this modulation. In addition, neostriatal projection neurons express D 1 or D 2 receptors (Surmeier et al, 1993;Hernandez-Lopez et al, 1997, 2000Aizman et al, 2000), and consistent presynaptic actions as the result of the activation of these receptors have been reported at the target nuclei (Floran et al, 1990(Floran et al, , 1997Cameron and Williams, 1993;Radnikow and Misgeld, 1998;Cooper and Stanford, 2001). Moreover, D 1 postsynaptic actions are facilitatory (Hernandez-Lopez et al, 1997), whereas D 2 postsynaptic actions depress firing (Hernandez-Lopez et al, 2000) in spiny neurons.…”

Section: Ipscs From Axon Collateralsmentioning

confidence: 64%

“…With this method, a presynaptic D 2 -mediated modulation similar to that shown on the striatopallidal pathway (Cooper and Stanford, 2001;Mengual and Pickel, 2002) or in the cholinergic or fastspiking (FS) interneurons (Pisani et al, 2000;Momiyama and Koga, 2001;Centonze et al, 2003) was shown. Similarly, a presynaptic modulation by D 1 receptor agonists as that reported in the striatonigral pathway (Floran et al, 1990(Floran et al, , 1997Cameron and Williams, 1993;Radnikow and Misgeld, 1998) was also shown, despite postsynaptic dopaminergic actions (Pacheco-Cano et al, 1996) on the subthreshold inward rectification Nisenbaum and Wilson, 1995;Mermelstein et al, 1998;Farries and Perkel, 2000) that shunts inhibitory inputs (Fitzpatrick et al, 2001).…”

Section: Discussionmentioning

confidence: 79%

“…Measurement of PPR has proven to be a reliable method for studying presynaptic modulation (Dunwiddie and Haas, 1985;Kamiya and Zucker, 1994;Zucker, 1999;Barral et al, 2001;Cooper and Stanford, 2001;Gerdeman et al, 2002). With this method, a presynaptic D 2 -mediated modulation similar to that shown on the striatopallidal pathway (Cooper and Stanford, 2001;Mengual and Pickel, 2002) or in the cholinergic or fastspiking (FS) interneurons (Pisani et al, 2000;Momiyama and Koga, 2001;Centonze et al, 2003) was shown.…”

Section: Discussionmentioning

confidence: 96%

“…Synaptic terminals from spiny neurons are presynaptically modulated by dopamine at their target nuclei (e.g., pallidum and substantia nigra reticulata) (Floran et al, 1990(Floran et al, , 1997Radnikow and Misgeld, 1998;Cooper and Stanford, 2001). Consequently, our hypothesis was that the same type of regulation should be present within the neostriatum.…”

Section: Introductionmentioning

confidence: 95%

“…The globus pallidus (GP) was first lesioned with ibotenic acid to destroy intrinsic pallidal cells. Related questions were whether modulation produced by D 1 receptor agonists is different from, or even opposed to, that produced by D 2 receptor agonists (Floran et al, 1990(Floran et al, , 1997Radnikow and Misgeld, 1998;Cooper and Stanford, 2001) and whether spiny neurons from the direct and the indirect pathways (Gerfen and Young, 1988;Albin et al, 1989) are synaptically interconnected (Aronin et al, 1986;Bolam and Izzo, 1988;Yung et al, 1996).…”

Section: Introductionmentioning

confidence: 99%

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Dopaminergic Modulation of Axon Collaterals Interconnecting Spiny Neurons of the Rat Striatum

et al. 2003

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Dopamine is a critical modulator of striatal function; its absence produces Parkinson's disease. Most cellular actions of dopamine are still unknown. This work describes the presynaptic actions of dopaminergic receptor agonists on GABAergic transmission between neostriatal projection neurons. Axon collaterals interconnect projection neurons, the main axons of which project to other basal ganglia nuclei. Most if not all of these projecting axons pass through the globus pallidus. Thus, we lesioned the intrinsic neurons of the globus pallidus and stimulated neostriatal efferent axons antidromically with a bipolar electrode located in this nucleus. This maneuver revealed a bicuculline-sensitive synaptic current while recording in spiny cells. D 1 receptor agonists facilitated whereas D 2 receptor agonists depressed this synaptic current. In contrast, a bicuculline-sensitive synaptic current evoked by field stimulation inside the neostriatum was not consistently modulated, in agreement with previous studies. The data are discussed in light of the most recent experimental and modeling results. The conclusion was that inhibition of spiny cells by axon collaterals of other spiny cells is quantitatively important; however, to be functionally important, this inhibition might be conditioned to the synchronized firing of spiny neurons. Finally, dopamine exerts a potentially important role regulating the extent of lateral inhibition.

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Section: Ipscs From Axon Collateralsmentioning

confidence: 64%

Section: Discussionmentioning

confidence: 79%

Section: Discussionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Dopaminergic Modulation of Axon Collaterals Interconnecting Spiny Neurons of the Rat Striatum

et al. 2003

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Dual effects of intermittent or continuous L‐DOPA administration on gene expression in the globus pallidus and subthalamic nucleus of adult rats with a unilateral 6‐OHDA lesion

Nielsen

Soghomonian

2003

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Intermittent oral doses of levodopa (L-DOPA) are routinely used to treat Parkinson's disease, but with prolonged use can result in adverse motor complications, such as dyskinesia. Continuous administration of L-DOPA achieves therapeutic efficacy without producing this effect, yet the molecular mechanisms are unclear. This study examined, by in situ hybridization histochemistry, the effects of continuous or intermittent L-DOPA administration on gene expression in the globus pallidus and subthalamic nucleus of adult rats with a unilateral 6-hydroxydopamine (6-OHDA) lesion of the nigrostriatal pathway. Results were compared to 6-OHDA-treated rats receiving vehicle. Our results provide original evidence that continuous L-DOPA normalizes the 6-OHDA-lesion-induced increase in mRNA levels encoding for the 67 kDa isoform of glutamate decarboxylase in neurons of the globus pallidus and cytochrome oxidase subunit I mRNA levels in the subthalamic nucleus. The extent of normalization did not differ between the continuous and intermittent groups. In addition, intermittent L-DOPA induced an increase in the mRNA levels encoding for the 65 kDa isoform of glutamate decarboxylase in globus pallidus neurons ipsilateral to the lesion and a bilateral increase in c-fos mRNA expression in the subthalamic nucleus. These results suggest that continuous L-DOPA tends to normalize the 6-OHDA-lesion-induced alterations in cell signaling in the pallido-subthalamic loop. On the other hand, we propose that chronic intermittent L-DOPA exerts a dual effect by normalizing cell signaling in a subpopulation of neurons in the globus pallidus and subthalamic nucleus while inducing abnormal signaling in another subpopulation.

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Molecular, chemical, and anatomical characterization of globus pallidus dopamine D2 receptor mRNA‐containing neurons

Hoover¹,

Marshall²

2004

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Essential for normal movement, the globus pallidus (GP) is a prominent nucleus whose neurons project to all other basal ganglia nuclei. The GP is composed of at least two distinct neuron populations. GP neurons of the rodent contain either the calcium-binding protein parvalbumin (PV) or preproenkephalin (PPE) mRNA, differentially innervate several basal ganglia structures, and have distinct immediate early gene responses to dopamine agonists or antagonists. Recent research has revealed that dopamine directly influences GP neurons, with D2 receptors contributing to both pre- and postsynaptic effects of dopaminergic agents. The existence of D2 mRNA-expressing (D2+) GP neurons has been established, but little is known concerning their numbers, regional distribution, or relationship to pallidal subpopulations identified on the basis of PV immunocytochemistry, PPE mRNA, or axonal targets. Detection of pallidal D2 mRNA with a 35S-cRNA probe revealed that D2+ neurons are found throughout the GP, comprising approximately one-half of pallidal neurons, but they are most dense within a dorsoventral band in lateral GP. While a substantial proportion (42-51%) of all chemically and anatomically labeled pallidal neuron subpopulations expressed D2 transcript, the D2+ neurons exhibited both population-based and regional heterogeneities. Overall, the pallidostriatal cells had a greater density of D2 mRNA than did pallidosubthalamic cells. Also, compared to other pallidal regions, the ventromedial GP contained fewer D2+ cells, and the PPE mRNA-expressing cells in this region had lower densities of D2 mRNA per neuron. These results reveal heterogeneous chemical and anatomical properties of the extensive population of D2+ GP neurons, a potential cellular substrate for dopamine's effects in pallidum.

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Dopamine D2 receptor mediated presynaptic inhibition of striatopallidal GABAA IPSCs in vitro

Cited by 137 publications

References 44 publications

Dopaminergic Modulation of Axon Collaterals Interconnecting Spiny Neurons of the Rat Striatum

Dopaminergic Modulation of Axon Collaterals Interconnecting Spiny Neurons of the Rat Striatum

Dual effects of intermittent or continuous L‐DOPA administration on gene expression in the globus pallidus and subthalamic nucleus of adult rats with a unilateral 6‐OHDA lesion

Molecular, chemical, and anatomical characterization of globus pallidus dopamine D2 receptor mRNA‐containing neurons

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