2005
DOI: 10.1074/jbc.m505560200
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Dopamine D2-like Receptors Are Expressed in Pancreatic Beta Cells and Mediate Inhibition of Insulin Secretion

Abstract: Dopamine is a neurotransmitter that plays a critical role in neurological and psychiatric disorders, such as schizophrenia, Parkinson disease, and drug addiction (1). Increasing evidence also shows implication of dopamine in various physiological functions such as cell proliferation (2), gastrointestinal protection (3), and inhibition of prolactin secretion (4). Effects of dopamine on insulin secretion in general and on pancreatic beta cell function in particular have been poorly studied. Insulin exocytosis fr… Show more

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Cited by 225 publications
(235 citation statements)
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“…The pancreatic uptake of 111 In-labelled exendin was clearly decreased in patients with type 1 diabetes, with marked differences between diabetic patients and healthy individuals. To date, no other radiotracer tested for BCM determination has shown such large maximum differences between healthy individuals and patients with type 1 diabetes, nor has such a high interindividual variability of the uptake been reported previously [37][38][39][40][41][42][43][44]. A recent study in healthy individuals and patients with type 1 diabetes, involving PET after injection of [ 18 F]fluoropropyl-dihydrotetrabenazine ([ 18 F]FP-(+)-DTBZ), showed a maximum difference in pancreatic uptake of <40% [45].…”
Section: Discussionmentioning
confidence: 99%
“…The pancreatic uptake of 111 In-labelled exendin was clearly decreased in patients with type 1 diabetes, with marked differences between diabetic patients and healthy individuals. To date, no other radiotracer tested for BCM determination has shown such large maximum differences between healthy individuals and patients with type 1 diabetes, nor has such a high interindividual variability of the uptake been reported previously [37][38][39][40][41][42][43][44]. A recent study in healthy individuals and patients with type 1 diabetes, involving PET after injection of [ 18 F]fluoropropyl-dihydrotetrabenazine ([ 18 F]FP-(+)-DTBZ), showed a maximum difference in pancreatic uptake of <40% [45].…”
Section: Discussionmentioning
confidence: 99%
“…Cytosolic calcium concentration was monitored in INS-1E cells by ratiometric measurements of Fura-2 fluorescence with filters set at 340/380 nm for excitation and 510 nm for emission in multiwell mode as detailed previously (Rubi et al, 2005). ATP levels were assessed in INS-1E cells using a Seahorse XF e 24 Flux Analyzer (Seahorse Biosciences) as described (Vanderperre et al, 2016).…”
Section: Insulin Secretion Calcium Measurements Atp and Amino Acid mentioning
confidence: 99%
“…Indeed, chronic administration of sulpiride, a dopamine D2-D3 receptor antagonist, leads to elevated circulating insulin and glucose levels in rats during a glucose tolerance test (Baptista et al, 2002c). In addition, dopamine D2-like receptors are expressed in both rat and human pancreatic β cells and mediate inhibition of glucose-stimulated but not basal insulin secretion (Rubi et al, 2005). However, it is interesting to note that the risperidone-treated rats did not increase basal serum insulin significantly despite high occupancy of D2 receptors at the dose used.…”
Section: Effect Of Haloperidol or Risperidone On Body Tissue Compositionmentioning
confidence: 99%