Dopamine D2-Like Receptors and Behavioral Economics of Food Reinforcement

Soto, Paul L.; Hiranita, Takato; Xu, Ming; Hursh, Steven R.; Grandy, David K.; Katz, Jonathan L.

doi:10.1038/npp.2015.223

Cited by 19 publications

(14 citation statements)

References 37 publications

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“…Although effects on food did not reach statistical significance, it is perhaps worth noting that PG01037 was the only treatment that increased food intake after chronic administration in our studies, whereas L741,626 mostly decreased food-reinforced responding. This is consistent with recent studies using dopamine receptor knockout mice, which indicated that D 2 , rather D 3 or D 4 , receptors mediate reinforcing effects of food (Soto et al, 2016).…”

Section: Discussionsupporting

confidence: 93%

Effects of Acute and Chronic Treatments with Dopamine D₂ and D₃ Receptor Ligands on Cocaine versus Food Choice in Rats

Thomsen¹,

Barrett²,

Butler³

et al. 2017

J Pharmacol Exp Ther

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Dopamine D receptor ligands are potential medications for psychostimulant addiction. Medication assessment may benefit from preclinical studies that evaluate chronic medication effects on choice between an abused drug and an alternative, nondrug reinforcer. This study compared acute and chronic effects of dopamine D- and D-preferring ligands on choice between intravenous cocaine and palatable food in rats. Under baseline conditions, cocaine maintained dose-dependent increases in cocaine choice and reciprocal decreases in food choice. Acutely, the D agonist -(-)-norpropylapomorphine (NPA) and antagonist L-741,626 [3-[[4-(4-chlorophenyl)-4-hydroxypiperidin-l-yl]methyl-1-indole] produced leftward and rightward shifts in cocaine dose-effect curves, respectively, whereas the partial agonist terguride had no effect. All three drugs dose-dependently decreased food-maintained responding. Chronically, the effects of -(-)-norpropylapomorphine and L-741,626 on cocaine self-administration showed marked tolerance, whereas suppression of food-reinforced behavior persisted. Acute effects of the D ligands were less systematic and most consistent with nonselective decreases in cocaine- and food-maintained responding. Chronically, the D agonist PF-592,379 [5-[(2,5)-5-methyl-4-propylmorpholin-2-yl]pyridin-2-amine] increased cocaine choice, whereas an intermediate dose of the D antagonist PG01037 [-[()-4-[4-(2,3-dichlorophenyl)piperazin-1-yl]but-2-enyl]-4-pyridin-2-ylbenzamide] produced a therapeutically desirable decrease in cocaine choice early in treatment; however, tolerance to this effect developed, and lower and higher doses were ineffective. D ligands failed to significantly modify total cocaine intake but caused persistent decreases in food intake. Thus, D-and D-preferring ligands showed distinct profiles, consistent with different pharmacological actions. In addition, these results highlight the role of acute versus chronic treatment as a determinant of test drug effects. With the possible exception of the D antagonist PG01037, no ligand was promising in terms of cocaine addiction treatment.

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Section: Discussionsupporting

confidence: 93%

Effects of Acute and Chronic Treatments with Dopamine D₂ and D₃ Receptor Ligands on Cocaine versus Food Choice in Rats

Thomsen¹,

Barrett²,

Butler³

et al. 2017

J Pharmacol Exp Ther

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“…Although these earlier studies did not provide mathematical indices of elasticity of demand, recent studies demonstrated that low doses of the DA antagonist haloperidol and the DA depleting agent tetrabenazine increased point elasticity of demand (Salamone et al, 2017 ). Taken together, these findings are consistent with a recent article reporting that DA D2 receptor knockout also increased elasticity of demand (Soto et al, 2016 ).…”

Section: Summary General Conclusion and Broader Implicationssupporting

confidence: 92%

Dopamine, Effort-Based Choice, and Behavioral Economics: Basic and Translational Research

Salamone

Correa

Yang

et al. 2018

Front. Behav. Neurosci.

115

104

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Operant behavior is not only regulated by factors related to the quality or quantity of reinforcement, but also by the work requirements inherent in performing instrumental actions. Moreover, organisms often make effort-related decisions involving economic choices such as cost/benefit analyses. Effort-based decision making is studied using behavioral procedures that offer choices between high-effort options leading to relatively preferred reinforcers vs. low effort/low reward choices. Several neural systems, including the mesolimbic dopamine (DA) system and other brain circuits, are involved in regulating effort-related aspects of motivation. Considerable evidence indicates that mesolimbic DA transmission exerts a bi-directional control over exertion of effort on instrumental behavior tasks. Interference with DA transmission produces a low-effort bias in animals tested on effort-based choice tasks, while increasing DA transmission with drugs such as DA transport blockers tends to enhance selection of high-effort options. The results from these pharmacology studies are corroborated by the findings from recent articles using optogenetic, chemogenetic and physiological techniques. In addition to providing important information about the neural regulation of motivated behavior, effort-based choice tasks are useful for developing animal models of some of the motivational symptoms that are seen in people with various psychiatric and neurological disorders (e.g., depression, schizophrenia, Parkinson’s disease). Studies of effort-based decision making may ultimately contribute to the development of novel drug treatments for motivational dysfunction.

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“…In a more recent study with mice, Soto et al (2016) investigated the effect of economy type on elasticity of demand for food in mice. They equated food-deprivation level at the start of each session across economies by only running sessions on days when subjects were at 85% of free-feeding weights.…”

Section: Economy Type and Food Valuementioning

confidence: 99%

“…It is hard to estimate the extent to which deprivation level or economy type contributed to effects observed in such studies. It is worth reiterating, however, that a clear effect of economy type was observed when differences in food deprivation level could be ruled out as a potential alternative explanation (Soto et al, 2016). Equating deprivation and satiation across economies is a major challenge.…”

Section: Economy Type and Water Valuementioning

confidence: 99%

The effect of economy type on reinforcer value

Kearns

2019

Behavioural Processes

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This article reviews studies investigating the effect of economy type on reinforcer value. In a closed economy, consumption of the reinforcer depends entirely on the subject's behavior, whereas in an open economy it does not, due, for example, to the provision of free reinforcers after the session. In theory, reinforcers should have higher value in a closed economy than in an open economy. Experimental results relevant to this prediction and methods used to test economy type effects are summarized and discussed here. Studies have tested the effect of economy type on the value of a variety of reinforcers, including food, water, saccharin, various drugs, and video games. Subjects used have varied also and include humans, monkeys, rats, and mice. Whether economy type had an effect on reinforcer value appears to depend on the particular reinforcer studied and on the species used. In general, where there was a difference in reinforcer value across economies, the effect was consistent with the prediction that value should be lower in the open economy. In some studies, however, satiation across economy types may have been responsible for the difference, or at least contributed to it. Potential explanations for the economy type effect, including substitution of future reinforcers for current reinforcers, contingency degradation, anticipatory contrast, and optimal foraging, are discussed.

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Dopamine D2-Like Receptors and Behavioral Economics of Food Reinforcement

Cited by 19 publications

References 37 publications

Effects of Acute and Chronic Treatments with Dopamine D₂ and D₃ Receptor Ligands on Cocaine versus Food Choice in Rats

Effects of Acute and Chronic Treatments with Dopamine D₂ and D₃ Receptor Ligands on Cocaine versus Food Choice in Rats

Dopamine, Effort-Based Choice, and Behavioral Economics: Basic and Translational Research

The effect of economy type on reinforcer value

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Dopamine D2-Like Receptors and Behavioral Economics of Food Reinforcement

Cited by 19 publications

References 37 publications

Effects of Acute and Chronic Treatments with Dopamine D2 and D3 Receptor Ligands on Cocaine versus Food Choice in Rats

Effects of Acute and Chronic Treatments with Dopamine D2 and D3 Receptor Ligands on Cocaine versus Food Choice in Rats

Dopamine, Effort-Based Choice, and Behavioral Economics: Basic and Translational Research

The effect of economy type on reinforcer value

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Product

Resources

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Effects of Acute and Chronic Treatments with Dopamine D₂ and D₃ Receptor Ligands on Cocaine versus Food Choice in Rats

Effects of Acute and Chronic Treatments with Dopamine D₂ and D₃ Receptor Ligands on Cocaine versus Food Choice in Rats