Dopamine D2‐Like Receptor Signaling and Downregulation of Filamin‐A May Drive the Association Between Neighborhood Socioeconomic Status and CCR2 Expression on Monocytes
Abstract:Social determinants of health (SDoH) include socioeconomic, environmental, and psychological factors that impact health. Low neighborhood socioeconomic status (nSES) is a SDoH that associates with cardiovascular mortality in longitudinal studies. While nSES as a chronic stress contributes to adverse health outcomes, the molecular mechanisms and pathogenesis are poorly understood. Previously, we found that residing in lower nSES areas may alter monocyte expression of C‐C chemokine receptor type 2 (CCR2), a regu… Show more
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