Dopamine D2-like receptor-mediated inhibition of glutamatergic synaptic transmission onto dopaminergic neurons in the rat ventral tegmental area

Koga, Eiko; Momiyama, Toshihiko

doi:10.1016/s0168-0102(98)81932-9

Neuroscience Research

1998

DOI: 10.1016/s0168-0102(98)81932-9

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Dopamine D2-like receptor-mediated inhibition of glutamatergic synaptic transmission onto dopaminergic neurons in the rat ventral tegmental area

Eiko Koga¹,

Toshihiko Momiyama²

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2000

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“…Preliminary results have been published previously in an abstract form (Koga & Momiyama, 1998, 1999).…”

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confidence: 99%

Presynaptic dopamine D₂‐like receptors inhibit excitatory transmission onto rat ventral tegmental dopaminergic neurones

Koga

Momiyama

2000

The Journal of Physiology

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The effects of dopamine (DA) on non‐NMDA glutamatergic transmission onto dopaminergic neurones in the ventral tegmental area (VTA) were examined in rat midbrain slices using the whole‐cell patch‐clamp technique. EPSCs in dopaminergic neurones evoked by focal stimulation within the VTA were reversibly blocked by 5 μM CNQX in the presence of bicuculline (20 μM), strychnine (0.5 μM) and D‐amino‐5‐phosphonopentanoic acid (D‐AP5, 25 μM). Bath application of DA reduced the amplitude of EPSCs up to 65.1 ± 9.52% in a concentration‐dependent manner between 0.3‐1000 μM (IC50, 16.0 μM) without affecting the holding current at −60 mV measured using a Cs+‐filled electrode. The effect of DA on evoked EPSCs was mimicked by the D2‐like receptor agonist quinpirole but not by the D1‐like receptor agonist SKF 81297, and was antagonized by the D2‐like receptor antagonist sulpiride (KB, 0.96 μM), but not by the D1‐like receptor antagonist SCH 23390 (KB, 228.6 μM). Dopamine (30 μM) reduced the mean frequency of spontaneous miniature EPSCs (mEPSCs) without affecting their mean amplitude, and the DA‐induced effect on the mEPSCs was dependent on the external Ca2+ concentration. These results suggest that afferent glutamatergic fibres which terminate on VTA dopaminergic neurones possess presynaptic D2‐like receptors, activation of which inhibits glutamate release by reducing Ca2+ influx.

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“…Preliminary results have been published previously in an abstract form (Koga & Momiyama, 1998, 1999).…”

mentioning

confidence: 99%

Presynaptic dopamine D₂‐like receptors inhibit excitatory transmission onto rat ventral tegmental dopaminergic neurones

Koga

Momiyama

2000

The Journal of Physiology

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Dopamine D2-like receptor-mediated inhibition of glutamatergic synaptic transmission onto dopaminergic neurons in the rat ventral tegmental area

Cited by 1 publication

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Presynaptic dopamine D₂‐like receptors inhibit excitatory transmission onto rat ventral tegmental dopaminergic neurones

Presynaptic dopamine D₂‐like receptors inhibit excitatory transmission onto rat ventral tegmental dopaminergic neurones

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Dopamine D2-like receptor-mediated inhibition of glutamatergic synaptic transmission onto dopaminergic neurons in the rat ventral tegmental area

Cited by 1 publication

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Presynaptic dopamine D2‐like receptors inhibit excitatory transmission onto rat ventral tegmental dopaminergic neurones

Presynaptic dopamine D2‐like receptors inhibit excitatory transmission onto rat ventral tegmental dopaminergic neurones

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Presynaptic dopamine D₂‐like receptors inhibit excitatory transmission onto rat ventral tegmental dopaminergic neurones

Presynaptic dopamine D₂‐like receptors inhibit excitatory transmission onto rat ventral tegmental dopaminergic neurones