Dopamine D1 receptors in the nucleus accumbens: involvement in the reinforcing effect of tegmental stimulation

Kurumiya, Satoshi; Nakajima, Shinshu

doi:10.1016/0006-8993(88)91095-5

Cited by 54 publications

(16 citation statements)

References 31 publications

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“…These data support the idea that concurrent activation of D 1 -and D 2 -type receptors is involved in DA-mediated reinforcement processes within the ACB. Findings from the ICSA studies of Phillips et al (1994) and the brain electrical self-stimulation experiments of Kurumiya and Nakajima (1988) and Nakajima (1989) are in agreement with this interpretation. Phillips et al (1994) reported that coadministration of the D 1 antagonist SCH 23390 or the D 2 antagonist sulpiride decreased the rewarding effects of self-infusion of amphetamine into the ACB.…”

Section: Interaction Of D 1 -And D 2 -Type Receptorssupporting

confidence: 78%

“…Phillips et al (1994) reported that coadministration of the D 1 antagonist SCH 23390 or the D 2 antagonist sulpiride decreased the rewarding effects of self-infusion of amphetamine into the ACB. Microinjection of either the D 2 antagonist raclopride or the D 1 antagonist SCH 23390 alone into the ACB diminished brain electrical self-stimulation behavior (Kurumiya and Nakajima, 1988;Nakajima, 1989).…”

Section: Interaction Of D 1 -And D 2 -Type Receptorsmentioning

confidence: 97%

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Role of Dopamine D₁and D₂Receptors in the Nucleus Accumbens in Mediating Reward

et al. 1997

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The objectives of this study were to examine the involvement of D 1 and D 2 receptors within the nucleus accumbens (ACB) in mediating reinforcement. The intracranial self-administration (ICSA) of D 1 and D 2 agonists was used to determine whether activating D 1 and/or D 2 receptors within the ACB of Wistar rats is reinforcing. At concentrations of 0.25, 0.50, and 1.0 mM (25, 50, and 100 pmol/100 nl of infusion), neither the D 1 agonist R(ϩ)- 3,4,] hydrochloride nor the D 2 agonist (Ϫ)-quinpirole (Quin) hydrochloride was self-administered into the shell region of the ACB. On the other hand, equimolar mixtures of SKF and Quin (SKFϩQuin), at concentrations of 0.25, 0.50, and 1.0 mM each, were significantly self-infused into the ACB shell. The core region of the ACB did not support the ICSA of SKFϩQuin at any of these concentrations. Rats increased lever pressing when the response requirement was increased from a fixed ratio 1 (FR1) to FR3, and they responded significantly more on the infusion lever than they did on the control lever. Coadministration of either 0.50 mM R(ϩ) -7-chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine (SCH 23390) hydrochloride, a D 1 antagonist, or 0.50 mM S(Ϫ)-sulpiride, a D 2 antagonist, completely abolished the ICSA of the mixture of SKFϩQuin (each at 0.50 mM) into the ACB shell. The present results suggest that concurrent activation of D 1 -and D 2 -type receptors in the shell of the ACB had a cooperative effect on DA-mediated reward processes.

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Section: Interaction Of D 1 -And D 2 -Type Receptorssupporting

confidence: 78%

Section: Interaction Of D 1 -And D 2 -Type Receptorsmentioning

confidence: 97%

Role of Dopamine D₁and D₂Receptors in the Nucleus Accumbens in Mediating Reward

et al. 1997

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“…1989). While the affinity for the D 2 receptor predicts neuroleptic potency in blocking the reinforcing effect of brain stimulation (Gallistel and Davis, 1983;Lynch and Wise, 1985), the effect is reduced by a D 1 selective blocker (SCH 23390) but not by D 2 selective sulpiride (Nakajima, 1986;Nakajima and McKenzie, 1986;Kurumiya and Nakajima, 1988). The involvement of D 1 receptors in reward is also suggested in place preference conditioning experiments (Shippenberg and Herz, 1987).…”

Section: Towards a More Complete Model Of The Striatummentioning

confidence: 92%

Striatal dopamine in motor activation and reward-mediated learning: steps towards a unifying model

Wickens

1990

J. Neural Transmission

133

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On the basis of behavioural evidence, dopamine is found to be involved in two higher-level functions of the brain: reward-mediated learning and motor activation. In these functions dopamine appears to mediate synaptic enhancement in the corticostriatal pathway. However, in electrophysiological studies, dopamine is often reported to inhibit corticostriatal transmission. These two effects of dopamine seem incompatible. The existence of separate populations of dopamine receptors, differentially modulating cholinergic and glutamatergic synapses, suggests a possible resolution to this paradox. The synaptic enhancement which occurs in reward-mediated learning may also be involved in dopamine-mediated motor activation. The logical form of reward-mediated learning imposes constraints on which mechanisms can be considered possible. Dopamine D1 receptors may mediate enhancement of corticostriatal synapses. On the other hand, dopamine D2 receptors on cholinergic terminals may mediate indirect, inhibitory effects of dopamine on striatal neurons.

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“…Dopamine (DA) is implicated in reward-related learning (Wise and Rompré 1989;Wise and Bozarth 1987;Berridge 1995;Wise 2004) and is thought to mediate the incentive motivational effects of reinforcers (Berridge and Robinson 1998;Ikemoto and Panksepp 1999;Wise 2004). Rewards can elevate extracellular DA concentrations in mesocorticolimbic and mesostriatal systems (Hernandez and Hoebel 1988;Bradberry and Roth 1989;Pettit and Justice 1989;Chen and Reith 1994;Ranaldi et al 1999), and DA neurotransmission in these pathways appears critical for their rewarding effects; reductions in DA neurotransmission in the nucleus accumbens (NAcc), medial prefrontal cortex (mPFC), ventral tegmental area (VTA), striatum, or substantia nigra reduce responding maintained by food Aberman et al 1998;SmithRoe and Kelley 2000;Baldwin et al 2002;Sharf et al 2005), cocaine (McGregor and Roberts 1993;Ranaldi and Wise 2001;Quinlan et al 2004), or VTA brain stimulation (Kurumiya and Nakajima 1988).…”

Section: Introductionmentioning

confidence: 98%

Blockade of muscarinic acetylcholine receptors in the ventral tegmental area prevents acquisition of food-rewarded operant responding in rats

2006

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Dopamine D1 receptors in the nucleus accumbens: involvement in the reinforcing effect of tegmental stimulation

Cited by 54 publications

References 31 publications

Role of Dopamine D₁and D₂Receptors in the Nucleus Accumbens in Mediating Reward

Role of Dopamine D₁and D₂Receptors in the Nucleus Accumbens in Mediating Reward

Striatal dopamine in motor activation and reward-mediated learning: steps towards a unifying model

Blockade of muscarinic acetylcholine receptors in the ventral tegmental area prevents acquisition of food-rewarded operant responding in rats

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Dopamine D1 receptors in the nucleus accumbens: involvement in the reinforcing effect of tegmental stimulation

Cited by 54 publications

References 31 publications

Role of Dopamine D1and D2Receptors in the Nucleus Accumbens in Mediating Reward

Role of Dopamine D1and D2Receptors in the Nucleus Accumbens in Mediating Reward

Striatal dopamine in motor activation and reward-mediated learning: steps towards a unifying model

Blockade of muscarinic acetylcholine receptors in the ventral tegmental area prevents acquisition of food-rewarded operant responding in rats

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Role of Dopamine D₁and D₂Receptors in the Nucleus Accumbens in Mediating Reward

Role of Dopamine D₁and D₂Receptors in the Nucleus Accumbens in Mediating Reward