Dopamine D1 receptor subtype mediates acute stress-induced dendritic growth in excitatory neurons of the medial prefrontal cortex and contributes to suppression of stress susceptibility in mice

Shinohara, Ryota; Taniguchi, Masayuki; Ehrlich, Aliza T.; Yokogawa, Kentarou; Deguchi, Yuichi; Chérasse, Yoan; Lazarus, Michael; Urade, Yoshihiro; Ogawa, Atsubumi; Kitaoka, Siho; Sawa, Akira; Narumiya, Shuh; Furuyashiki, Tomoyuki

doi:10.1038/mp.2017.177

Cited by 86 publications

(86 citation statements)

References 76 publications

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“…Evidence has been provided that DA mediates dendritic/axonal growth (Parish et al, 2001; Penrod et al, 2015; Shinohara et al, 2017) and facilitates the induction of Hebbian synaptic plasticity and learning and memory (Gangarossa and Valjent, 2012; Sariñana et al, 2014; Ntamati and Lüscher, 2016). Whether DA is instructive in mediating these effects, or rather permissive (by blocking homeostasis), requires further investigation.…”

Section: Discussionmentioning

confidence: 99%

Dopamine Modulates Homeostatic Excitatory Synaptic Plasticity of Immature Dentate Granule Cells in Entorhino-Hippocampal Slice Cultures

Strehl

Galanis

Radic

et al. 2018

Front. Mol. Neurosci.

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Homeostatic plasticity mechanisms maintain neurons in a stable state. To what extent these mechanisms are relevant during the structural and functional maturation of neural tissue is poorly understood. To reveal developmental changes of a major homeostatic plasticity mechanism, i.e., homeostatic excitatory synaptic plasticity, we analyzed 1-week- and 4-week-old entorhino-hippocampal slice cultures and investigated the ability of immature and mature dentate granule cells (GCs) to express this form of plasticity. Our experiments demonstrate that immature GCs are capable of adjusting their excitatory synaptic strength in a compensatory manner at early postnatal stages, i.e., in 1-week-old preparations, as is the case for mature GCs. This ability of immature dentate GCs is absent in 4-week-old slice cultures. Further investigations into the signaling pathways reveal an important role of dopamine (DA), which prevents homeostatic synaptic up-scaling of immature GCs in young cultures, whereas it does not affect immature and mature GCs in 4-week-old preparations. Together, these results disclose the ability of immature GCs to express homeostatic synaptic plasticity during early postnatal development. They hint toward a novel role of dopaminergic signaling, which may gate activity-dependent changes of newly born neurons by blocking homeostasis.

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Section: Discussionmentioning

confidence: 99%

Dopamine Modulates Homeostatic Excitatory Synaptic Plasticity of Immature Dentate Granule Cells in Entorhino-Hippocampal Slice Cultures

Strehl

Galanis

Radic

et al. 2018

Front. Mol. Neurosci.

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“…Interindividual variation may also be relevant in determining treatment response. There is evidence that repeated stress exposure disrupts D1 signaling in the prefrontal cortex (Shinohara et al, 2018). Given the complexities of dopamine signaling (different receptor subtypes, brain regional and cell-type-specific differences in dopaminergic regulation, temporal-specific effects during learning) (Bamford et al, 2018), additional study of these agents is needed to determine their place in PTSD therapeutics.…”

Section: Discussionmentioning

confidence: 99%

Genomic Characterization of Posttraumatic Stress Disorder in a Large US Military Veteran Sample

Stein

Levey

Cheng

et al. 2019

Preprint

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Individuals vary in their liability to develop Posttraumatic Stress Disorder (PTSD), the symptoms of which are highly heterogeneous, following exposure to life-threatening trauma. Understanding genetic factors that contribute to the biology of PTSD is critical for refining diagnosis and developing new treatments. Using genetic data from more than 250,000 participants in the Million Veteran Program, genomewide association analyses were conducted using a validated electronic health record-based algorithmically-defined PTSD diagnosis phenotype (48,221 cases and 217,223 controls), and PTSD quantitative symptom phenotypes (212,007 individuals). We identified several genome-wide significant loci in the case-control analyses, and numerous such loci in the quantitative trait analyses, including some (e.g., MAD1L1; TCF4; CRHR1) that were associated with multiple symptom sub-domains and total symptom score, and others that were more specific to certain symptom sub-domains (e.g., CAMKV to reexperiencing; SOX6 to hyperarousal). Genetic correlations between all pairs of symptom sub-domains and their total were very high (rg 0.93 -0.98) supporting validity of the PTSD diagnostic construct. We also demonstrate strong shared heritability with a range of traits, show that heritability persists when conditioned on other major psychiatric disorders, present independent replication results, provide support for one of the implicated genes in postmortem brain of individuals with PTSD, and use this information to identify potential drug repositioning candidates. These results point to the utility of genetics to inform and validate the biological coherence of the PTSD syndrome despite considerable heterogeneity at the symptom level, and to provide new directions for treatment development.

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“…Social defeat stress was performed as previously described with minor modifications . In the present study, we subjected 9‐week‐old male C57BL/6N mice to single social defeat stress.…”

Section: Methodsmentioning

confidence: 99%

“…Social defeat stress was performed as previously described with minor modifications. 6,15 In the present study, we subjected 9-weekold male C57BL/6N mice to single social defeat stress. Prior to social defeat stress, male ICR mice were screened for their aggressiveness to a novel C57BL/6N mouse for 3 minutes daily for 3 days.…”

Section: Social Defeat Stressmentioning

confidence: 99%

“…We previously reported that single exposure to social defeat stress induces the phosphorylation of extracellular signal-regulated kinase (ERK) at Thr202 and Tyr204 residues coupled to dopamine D1 receptor activation in the medial prefrontal cortex in mice. 15 In this study, we examined the ERK phosphorylation in other brain areas or cell types and happened to find that single exposure to social defeat stress induces the ERK phosphorylation in the leptomeninges.…”

Section: Introductionmentioning

confidence: 99%

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Social defeat stress induces phosphorylation of extracellular signal‐regulated kinase in the leptomeninges in mice

Okamura

Nagai

Numa

et al. 2019

Neuropsychopharm Rep

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Aims Animal studies using various stress models have shown that excessive environmental stress induces depression? and anxiety?like behaviors through inflammatory responses in the brain and periphery. Although the leptomeningeal cells have multiple functions related to inflammatory responses in the brain, whether environmental stress influences the leptomeninges remains unknown. In this study, we aimed to examine phosphorylation of the extracellular signal‐regulated kinase (ERK) in the leptomeninges. Methods We subjected C57BL/6 male mice to a single episode of social defeat stress and analyzed the expression of phosphorylated ERK in the leptomeninges by immunohistochemistry. Results Social defeat stress in mice induced phosphorylation of ERK in the leptomeninges, adjacent to vascular endothelial cells and the glia limitans. This ERK phosphorylation was maintained for at least one hour after the stress. Conclusions This study shows the effect of environmental stress on the leptomeninges for the first time and paves the way for elucidating its functional role in stress‐induced changes in neural functions.

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Dopamine D1 receptor subtype mediates acute stress-induced dendritic growth in excitatory neurons of the medial prefrontal cortex and contributes to suppression of stress susceptibility in mice

Abstract: Dopamine D1 receptor subtype mediates acute stress-induced dendritic growth in excitatory neurons of the medial prefrontal cortex and contributes to suppression of stress susceptibility in mice

Cited by 86 publications

References 76 publications

Dopamine Modulates Homeostatic Excitatory Synaptic Plasticity of Immature Dentate Granule Cells in Entorhino-Hippocampal Slice Cultures

Dopamine Modulates Homeostatic Excitatory Synaptic Plasticity of Immature Dentate Granule Cells in Entorhino-Hippocampal Slice Cultures

Genomic Characterization of Posttraumatic Stress Disorder in a Large US Military Veteran Sample

Social defeat stress induces phosphorylation of extracellular signal‐regulated kinase in the leptomeninges in mice

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