Dopamine D1 receptor activity is involved in the increased anxiety levels observed in STZ-induced diabetes in rats

Rebolledo-Solleiro, Daniela; Araiza, Luis Fernando Ontiveros; Broccoli, Laura; Hansson, Anita C.; Rocha-Arrieta, Luisa L.; Aguilar‐Roblero, Raúl; Crespo-Ramírez, Minerva; Fuxé, Kjell; Mora, Miguel Pérez de la

doi:10.1016/j.bbr.2016.06.060

Cited by 13 publications

(6 citation statements)

References 49 publications

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“…Taken together with the increase of SAP in diabetic rats, this may be interpreted as an increase in ALB. Furthermore, since diabetic animals seem to pre- fer passive strategies to cope with anxiogenic stimuli (Rebolledo-Solleiro et al, 2016), due to their poorer physical conditions, freezing may be a better behavioral measure for assessing ALB. Additionally, freezing responses are associated with anxiety and may be etiologically related to several anxiety disorders (Riskind et al, 2016), and they have also been used to model anxiety disorders (Likhtik et al, 2005).…”

Section: Discussionmentioning

confidence: 99%

Aerobic exercise has an anxiolytic effect on streptozotocin-induced diabetic rats

Çalışkan¹,

Akat²,

Ömercioğlu³

et al. 2020

Acta Neurobiologiae Experimentalis

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Diabetes is a metabolic disorder characterized by hyperglycemia and impaired insulin secretion or action. Psychological comorbidities, such as depression and anxiety, are more common in people with diabetes. Exercise results in anxiolytic effects, as demonstrated in numerous studies. This study aims to evaluate potential anxiolytic effects of aerobic exercise in streptozotocin (STZ)-induced diabetes. Male Wistar albino rats (n=40) were randomly divided into four groups of control, exercise, diabetes, and diabetes + exercise. Diabetes was induced with a single i.p. injection of STZ. The incremental load test was applied to exercise groups to determine maximal exercise capacity. Rats exercised on a treadmill at 70% of their maximal capacity for 45 min, five days per week for 12 weeks. On the day after the last exercise session the open field test and elevated plus maze test were carried out. Diabetes caused an increase in anxiety level, reflected in stretch-attend posture, self-grooming behaviors, and freezing time, with no significant changes for other behavioral parameters. Training normalized diabetes-induced deteriorations and also induced a significant anxiolytic effect both on diabetic and non-diabetic rats. This effect was observed for all behavioral parameters. The results of the open field test and elevated plus maze were consistent. The current results demonstrated a slight increase in anxiety with diabetes and a prominent anxiolytic effect of aerobic exercise. Considering the conflicting results in exercise-anxiety studies, this study highlights the importance of individually designed exercise protocols.

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Section: Discussionmentioning

confidence: 99%

Aerobic exercise has an anxiolytic effect on streptozotocin-induced diabetic rats

Çalışkan¹,

Akat²,

Ömercioğlu³

et al. 2020

Acta Neurobiologiae Experimentalis

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“…Since VTA neurons are the origin of the dopamine (DA) innervation of the amygdala [67] and it has been demonstrated that conditional knock-out mice lacking leptin receptor (Lepr dat-Cre mice) in the VTA show an anxiogenic profile [58], it is conceivable that leptin resistance within VTA may underlie the anxiety behavior observed in our experiments. Moreover, it is tempting to speculate, that such anxiogenic effects may be mediated through activity of dopamine D1 receptors since the intra-amygdaloid administration of SCH-23390, a selective D1 receptor antagonist, attenuated anxiety in Lepr dat-Cre mice [58] and induces anxiolytic responses in rats subjected both to the LDBT [67], the EPM [68] and the SPBT [69]. …”

Section: Discussionmentioning

confidence: 99%

Increased anxiety-like behavior is associated with the metabolic syndrome in non-stressed rats

et al. 2017

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Metabolic syndrome (MS) is a cluster of signs that increases the risk to develop diabetes mellitus type 2 and cardiovascular disease. In the last years, a growing interest to study the relationship between MS and psychiatric disorders, such as depression and anxiety, has emerged obtaining conflicting results. Diet-induced MS rat models have only examined the effects of high-fat or mixed cafeteria diets to a limited extent. We explored whether an anxiety-like behavior was associated with MS in non-stressed rats chronically submitted to a high-sucrose diet (20% sucrose in drinking water) using three different anxiety paradigms: the shock-probe/burying test (SPBT), the elevated plus-maze (EPM) and the open-field test (OFT). Behaviorally, the high-sucrose diet group showed an increase in burying behavior in the SPBT. Also, these animals displayed both avoidance to explore the central part of the arena and a significant increase in freezing behavior in the OFT and lack of effects in the EPM. Also, high-sucrose diet group showed signs of an MS-like condition: significant increases in body weight and body mass index, abdominal obesity, hypertension, hyperglycemia, hyperinsulinemia, and dyslipidemia. Plasma leptin and resistin levels were also increased. No changes in plasma corticosterone levels were found. These results indicate that rats under a 24-weeks high-sucrose diet develop an MS associated with an anxiety-like behavior. Although the mechanisms underlying this behavioral outcome remain to be investigated, the role of leptin is emphasized.

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“…The control rats were provided with the same volume and duration of citrate buffer alone. The STZ dosage was selected based on earlier report ( 13 ). In addition, the fasting glucose was measured on the second day after STZ injections to assess the success of the established type 1 diabetes model.…”

Section: Methodsmentioning

confidence: 99%

Systematic assessment of streptozotocin-induced diabetic metabolic alterations in rats using metabolomics

Guo

Yang

et al. 2023

Front. Endocrinol.

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PurposeType 1 diabetes is characterized by elevated blood glucose levels, which negatively impacts multiple organs and tissues throughout the body, and its prevalence is on the rise. Prior reports primarily investigated the serum and urine specimen from diabetic patients. However, only a few studies examined the overall metabolic profile of diabetic animals or patients. The current systemic investigation will benefit the knowledge of STZ-based type 1 diabetes pathogenesis.MethodsMale SD rats were arbitrarily separated into control and streptozotocin (STZ)-treated diabetic rats (n = 7). The experimental rats received 50mg/kg STZ intraperitoneal injection daily for 2 consecutive days. Following 6 weeks, metabolites were assessed via gas chromatography-mass spectrometry (GC-MS), and multivariate analysis was employed to screen for differentially expressed (DE) metabolites between the induced diabetic and normal rats.ResultsWe identified 18, 30, 6, 24, 34, 27, 27 and 12 DE metabolites in the serum, heart, liver, kidney, cortex, renal lipid, hippocampus, and brown fat tissues of STZ-treated diabetic rats, compared to control rats. Based on our analysis, the largest differences were observed in the amino acids (AAs), B-group vitamin, and purine profiles. Using the metabolic pathway analysis, we screened 13 metabolic pathways related to the STZ-exposed diabetes pathogenesis. These pathways were primarily AA metabolism, followed by organic acids, sugars, and lipid metabolism.ConclusionBased on our GC-MS analysis, we identified potential metabolic alterations within the STZ-exposed diabetic rats, which may aid in the understanding of diabetes pathogenesis.

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Dopamine D1 receptor activity is involved in the increased anxiety levels observed in STZ-induced diabetes in rats

Cited by 13 publications

References 49 publications

Aerobic exercise has an anxiolytic effect on streptozotocin-induced diabetic rats

Aerobic exercise has an anxiolytic effect on streptozotocin-induced diabetic rats

Increased anxiety-like behavior is associated with the metabolic syndrome in non-stressed rats

Systematic assessment of streptozotocin-induced diabetic metabolic alterations in rats using metabolomics

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