Dopamine D1-like receptor blockade and stimulation decreases operant responding for nicotine and food in male and female rats

Chellian, Ranjithkumar; Behnood‐Rod, Azin; Wilson, Ryann; Lin, Karen; King, Grace Wing-Yan; Ruppert-Gomez, Marcella; Teter, Alexandria Nicole; Febo, Marcelo; Bruijnzeel, Adrie W.

doi:10.1038/s41598-022-18081-3

Cited by 7 publications

(18 citation statements)

References 68 publications

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“…have sedative effects or induce motor impairments by evaluating their effects on locomotor activity in Wistar rats. 36 Treatment with 0.01 and 0.03 mg/kg of SCH 23390 decreased locomotor activity in male rats. In contrast, treatment with A77636 did not affect locomotor activity.…”

Section: Discussionmentioning

confidence: 94%

“…In our previous work, we determined if SCH 23390 and A77636 have sedative effects or induce motor impairments by evaluating their effects on locomotor activity in Wistar rats 36 . Treatment with 0.01 and 0.03 mg/kg of SCH 23390 decreased locomotor activity in male rats.…”

Section: Discussionmentioning

confidence: 99%

“…There were at least 48 h between injections with SCH 23390 and 72 h between injections with A77636. The doses of SCH 23390 and A77636 were based on a previous study with rats 36 . During the self‐administration period, the rats received 90–95% of their normal ad libitum food intake in the home cage.…”

Section: Methodsmentioning

confidence: 99%

“…The catheters were implanted as described before. 26,36,37 The rats were anaesthetised with an isoflurane-oxygen vapour mixture (1-3%) and prepared with a catheter in the right jugular vein. The catheters consisted of polyurethane tubing (length 10 cm, inner diameter 0.64 mm, outer diameter 1.0 mm, model 3Fr, Instech Laboratories, Plymouth Meeting, PA).…”

Section: Intravenous Catheter Implantationmentioning

confidence: 99%

“…The doses of SCH 23390 and A77636 were based on a previous study with rats. 36 During the self-administration period, the rats received 90-95% of their normal ad libitum food intake in the home cage. The rats were fed (23 g) immediately after the operant sessions.…”

Section: Experimental Designmentioning

confidence: 99%

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Dopamine D1‐like receptor activation decreases nicotine intake in rats with short or long access to nicotine

et al. 2023

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The use of nicotine and tobacco products is highly addictive. The dopaminergic system plays a key role in the initiation and maintenance of nicotine intake. Dopamine D1‐like receptor blockade diminishes nicotine intake in rats with daily short (1 h) access to nicotine, but little is known about the effects of dopamine receptor antagonists or agonists on nicotine intake in rats with intermittent long (23 h) access. Because of the extended access conditions and high nicotine intake, the intermittent long access procedure might model smoking and vaping better than short access models. We investigated the effects of the dopamine D1‐like receptor antagonist SCH 23390 and the D1‐like receptor agonist A77636 on nicotine intake in male rats with intermittent short or long access to nicotine. The rats self‐administered nicotine for 5 days (1 h/day) and were then given 15 intermittent short (1 h/day) or long (23 h/day) access sessions (3 sessions/week, 0.06 mg/kg/inf). The D1‐like receptor antagonist SCH 23390 decreased nicotine intake to a similar degree in rats with short or long access to nicotine. The D1‐like receptor agonist A77636 induced a greater decrease in nicotine intake in the rats with long access to nicotine than in rats with short access. Treatment with A77636 induced a prolonged decrease in nicotine intake that lasted throughout the dark and light phase in the long access rats. These findings indicate that blockade and stimulation of D1‐like receptors decrease nicotine intake in an intermittent long access animal model that closely models human smoking and vaping.

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Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Intravenous Catheter Implantationmentioning

confidence: 99%

Section: Experimental Designmentioning

confidence: 99%

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Dopamine D1‐like receptor activation decreases nicotine intake in rats with short or long access to nicotine

et al. 2023

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Fluorocitrate inhibition of astrocytes reduces nicotine self-administration and alters extracellular levels of glutamate and dopamine within the nucleus accumbens in male wistar rats

Tan,

Neslund,

Fentis

et al. 2024

Neuropharmacology

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No major effect of dopamine receptor 1/5 antagonist SCH‐23390 on epileptic activity in the Tg2576 mouse model of amyloidosis

B. Szabo,

Sayegh,

Gauzin

et al. 2024

Eur J of Neuroscience

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The excitation‐inhibition imbalance manifesting as epileptic activities in Alzheimer's disease is gaining more and more attention, and several potentially involved cellular and molecular pathways are currently under investigation. Based on in vitro studies, dopamine D1‐type receptors in the anterior cingulate cortex and the hippocampus have been proposed to participate in this peculiar co‐morbidity in mouse models of amyloidosis. Here, we tested the implication of dopaminergic transmission in vivo in the Tg2576 mouse model of Alzheimer's disease by monitoring epileptic activities via intracranial EEG before and after treatment with dopamine antagonists. Our results show that neither the D1‐like dopamine receptor antagonist SCH23390 nor the D2‐like dopamine receptor antagonist haloperidol reduces the frequency of epileptic activities. While requiring further investigation, our results indicate that on a systemic level, dopamine receptors are not significantly contributing to epilepsy observed in vivo in this mouse model of Alzheimer's disease.

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Dopamine D1-like receptor blockade and stimulation decreases operant responding for nicotine and food in male and female rats

Cited by 7 publications

References 68 publications

Dopamine D1‐like receptor activation decreases nicotine intake in rats with short or long access to nicotine

Dopamine D1‐like receptor activation decreases nicotine intake in rats with short or long access to nicotine

Fluorocitrate inhibition of astrocytes reduces nicotine self-administration and alters extracellular levels of glutamate and dopamine within the nucleus accumbens in male wistar rats

No major effect of dopamine receptor 1/5 antagonist SCH‐23390 on epileptic activity in the Tg2576 mouse model of amyloidosis

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