Dopamine — Clinical Uses of an Endogenous Catecholamine

Goldberg, Leon I.

doi:10.1056/nejm197410032911405

Cited by 340 publications

(71 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Dopamine, a natural precursor of norepinephrine, is a clinically useful inotropic agent (3,10,11,18). Although it has been studied extensively in the mature animal, little information is available concerning the effect of dopamine on the neonatal myocardium.…”

Section: Speculationmentioning

confidence: 99%

Inotropic Response of the Neonatal Canine Myocardium to Dopamine

et al. 1978

View full text Add to dashboard Cite

Section: Speculationmentioning

confidence: 99%

Inotropic Response of the Neonatal Canine Myocardium to Dopamine

et al. 1978

View full text Add to dashboard Cite

“…The catecholamines have limitations in that they are arrhythmogenic, are chronotropic, have a short duration of action, and cannot be given orally (Goldberg, 1968). Dopamine (Goldberg, 1974;Beregovich et al, 1974) and the synthetic catecholamine, amine dobutamine (Tuttle and Mills, 1975;Goldberg et al, 1977), both of which have been introduced recently for clinical use, suffer from most of the same drawbacks as the older catecholamines. Other inotropic agents, such as glucagon (Farah and Tuttle, 1960;Glick et al, 1968), anthopleurin-A (Shibata et al, 1978), theophyUine (Rail and West, 1963;Blinks et al, 1972), ionophores (Schwartz et al, 1974), imidazole (Knope et al, 1973), and others, have been studied but have not found general clinical application for the treatment of heart failure.…”

mentioning

confidence: 99%

Cardiotonic activity of amrinone--Win 40680 [5-amino-3,4'-bipyridine-6(1H)-one].

Alousi¹,

Farah²,

Lesher³

et al. 1979

Circulation Research

218

View full text Add to dashboard Cite

SUMMARYThe cardiotonic activity of a new, noncatechol, nonglycoside agent, amrinone, waa investigated in vitro and in anesthestized and unanesthetized dogs. Amrinone (3-1000 /ig/ml) caused a dose-dependent increase in papillary muscle developed tension and df/dt without significant changes in duration of the contractile cycle or time-to-peak tension. Amrinone induced slight increases in right atrial rate with no changes in electrophysiological properties of the cat papillary muscle or dog Purkinje fibers. In anesthetized dogs, intravenous bolus injections of amrinone at doses ranging from 1 to 10 mg/kg caused increases in cardiac contractile force and left ventricular dp/dt max with relatively small changes in heart rate and blood pressure. No significant changes in lead II ECG were observed. In unanesthetized dogs, intravenous infusion of amrinone (10-100 /ig/kg per min) caused increases in left ventricular dp/dt max and only small changes in heart rate and blood pressure. Amrinone, tested orally in this model at doses of 2-10 mg/kg, produced a positive inotropic effect with a rapid onset and long duration of action. The inotropic response to amrinone was not blocked by propranolol, dibenzyline, chlorisondamine, atropine, metiamide, or reserpine. Amrinone's inotropic response was not associated with significant alterations in cardiac norepinephrine, phosphodiesterase, cyclic AMP, or Na + ,K + -activated ATPase. Ore Res 45: 666-677, 1979 A LARGE number of agents have positive inotropic effects on the heart. However, of these, only two classes of compounds have been found to be useful in the treatment of heart failure in man. The cardiac glycosides have enjoyed a valued position for nearly 200 years in spite of the fact that they have a narrow therapeutic range, and digitalis intoxication is one of the most common drug-induced adverse reactions in this country (Mason et al., 1971;Beller et al., 1971;Doherty and Kane, 1975). The catecholamines have limitations in that they are arrhythmogenic, are chronotropic, have a short duration of action, and cannot be given orally (Goldberg, 1968). Dopamine (Goldberg, 1974;Beregovich et al., 1974) and the synthetic catecholamine, amine dobutamine (Tuttle and Mills, 1975;Goldberg et al, 1977), both of which have been introduced recently for clinical use, suffer from most of the same drawbacks as the older catecholamines. Other inotropic agents, such as glucagon (Farah and Tuttle, 1960;Glick et al., 1968) has proved of value in the management of congestive heart failure (Cohn and Franciosa, 1977;Mehta, 1977).The development of an orally active non-catechol and non-glycoside cardiotonic agent has been the goal of this laboratory for several years (Alousi and Farah, 1975;Alousi et al., 1978;Farah and Alousi, 1978). Amrinone (Win 40680), a 5-amino-3,4'-bipyridine-6(lH)-one, is a novel chemical entity with rather unique cardiac inotropic properties Farah and Alousi, 1978). In this report, the action of amrinone on the heart is studied in several models, and in light of these res...

show abstract

“…10 Facilitation of diuresis by inotropic therapy presumably reflects improved renal blood flow through modest increases in cardiac output. Although low doses of dopamine (1 to 3 g · kg Ϫ1 · min…”

Section: Congestion With Impaired Renal Responsesmentioning

confidence: 99%

“…This agent increases contractility and heart rate primarily through cardiac ␤-receptors and vasoconstriction through peripheral ␣-receptors at these doses. 9,10 Peripheral vasodilation can occur to a modest degree with dobutamine and to a major degree with milrinone, 11 so these agents are unlikely to improve this situation ( Figure 1). If blood pressure cannot be maintained acutely with increasing doses of dopamine, epinephrine can be used as a more potent agonist for both ␤-and ␣-receptors.…”

mentioning

confidence: 99%

Clinical Use of Inotropic Therapy for Heart Failure: Looking Backward or Forward? Part I: Inotropic Infusions During Hospitalization

Stevenson

2003

Circulation

View full text Add to dashboard Cite

Dopamine — Clinical Uses of an Endogenous Catecholamine

Cited by 340 publications

References 27 publications

Inotropic Response of the Neonatal Canine Myocardium to Dopamine

Inotropic Response of the Neonatal Canine Myocardium to Dopamine

Cardiotonic activity of amrinone--Win 40680 [5-amino-3,4'-bipyridine-6(1H)-one].

Clinical Use of Inotropic Therapy for Heart Failure: Looking Backward or Forward? Part I: Inotropic Infusions During Hospitalization

Contact Info

Product

Resources

About