Dopamine, BDNF and Motor Function Postbilateral Anodal Transcranial Direct Current Stimulation in Parkinson’s Disease

Hadoush, Hikmat; Banihani, Saleem Ali; Khalil, Hanan; Al-Qaisi, Yasir; Al‐Sharman, Alham; Al-Jarrah, Muhammed

doi:10.2217/nmt-2017-0048

Cited by 17 publications

(21 citation statements)

References 34 publications

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“…The mechanisms underlying improved retrieval of motor encoding even during untrained tasks are presently illusive. Recently, it was shown that bilateral atDCS increased brain-derived neurotrophic factor (BDNF) serum levels together with improved motor function in PD, 43 a result that was also found after intensive rehabilitation. 44 BDNF may play a role in processes that are involved in synaptic efficacy linked to neuroplasticity (i.e.…”

Section: Discussionmentioning

confidence: 95%

tDCS-Enhanced Consolidation of Writing Skills and Its Associations With Cortical Excitability in Parkinson Disease: A Pilot Study

Broeder

Nackaerts

Cuypers

et al. 2019

Neurorehabil Neural Repair

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Background. Learning processes of writing skills involve the re-engagement of previously established motor programs affected by Parkinson disease (PD). To counteract the known problems with consolidation in PD, transcranial direct current stimulation (tDCS) could be imperative to achieve a lasting regeneration of habitual motor skills. Objective. To examine tDCS-enhanced learning of writing and explore alterations in cortical excitability after stimulation in PD compared with healthy controls (HCs). Methods. Ten patients and 10 HCs received 2 training sessions combined with 20 minutes of 1-mA anodal tDCS or sham on the left primary motor cortex in a randomized crossover design. Writing skills on a tablet and paper were assessed at baseline, after training, and after 1 week of follow-up. Before and immediately after the intervention, cortical excitability and inhibition were measured during rest and activity. Results. Writing amplitude and velocity improved when practice was tDCS supplemented compared with sham in PD. Benefits were sustained at retention for trained and untrained tasks on the tablet as well as for writing on paper. No improvements were found for HCs. Reduced resting motor thresholds after tDCS indicated tDCS-enhanced cortical excitability. Additionally, increments in motor-evoked potential amplitudes correlated with improved writing in PD, whereas HCs showed the opposite pattern. Conclusion. Our results endorse the usefulness of tDCS-boosted learning in PD, at least when applied to improving writing capacity. Although further confirmatory studies are needed, these novel findings are striking because tDCS-mediated consolidation was found for learning a motor task directly affected by PD.

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Section: Discussionmentioning

confidence: 95%

tDCS-Enhanced Consolidation of Writing Skills and Its Associations With Cortical Excitability in Parkinson Disease: A Pilot Study

Broeder

Nackaerts

Cuypers

et al. 2019

Neurorehabil Neural Repair

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“…One study tested in both off and on dopaminergic medication [ 33 ], one tested in the off state [ 49 ], and one did not report medication status [ 52 ]. Five investigations had open-label designs [ 38 , 43 , 45 , 46 , 47 ]; seven were parallel arm, randomized, double-blind, sham-controlled designs [ 33 , 40 , 41 , 42 , 44 , 50 , 52 ]; and eight were crossover, randomized, sham-controlled designs, with six being double-blind [ 36 , 37 , 39 , 48 , 49 , 51 ] and two with unstated blinding [ 34 , 35 ]. The tDCS intensities ranged from 1 to 2.8 mA (range of current densities = 0.02 mA/cm 2 –0.12 mA/cm 2 ) and stimulation was applied for 7–30 min (mode = 20 min).…”

Section: Resultsmentioning

confidence: 99%

“…The third study did not have any unusual stimulation parameters that might explain the reported tingling and light flash experienced by one subject and the reported event might be attributed to the individual characteristics of that subject or slightly different electrode placement in that session [ 40 ]. Lastly, although the group sizes and characteristics were not identical, the possibility of at least some of the subjects being included in all three of the Hadoush et al papers is noted [ 45 , 46 , 47 ], and the results of Grüner et al [ 34 ] and Eggers et al [ 35 ] were explicitly stated to be from the same subjects.…”

Section: Resultsmentioning

confidence: 99%

Tolerability and Blinding of Transcranial Direct Current Stimulation in People with Parkinson’s Disease: A Critical Review

2020

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Transcranial direct current stimulation (tDCS) is accompanied by transient sensations (e.g., tingling, itching, burning), which may affect treatment outcomes or break the blinding of the study protocol. Assessing tolerability and blinding is integral to providing ample evidence of a “real effect” from the applied stimulation and dispelling the possibility of placebo effects. People with Parkinson’s disease (PwPD) endure many motor and non-motor symptoms that might be amenable to tDCS. However, because the disease also affects sensation capabilities, these subjects might report tolerability and blinding differently than other cohorts. Therefore, the purpose of this review was to aggregate the tolerability and blinding reports of tDCS studies in PwPD and recommend a standard tolerability and blinding reporting practice. A literature search of the PubMed and Scopus databases from 1 January 2020 to 1 April 2020 was performed to identify publications that applied tDCS to PwPD. Seventy studies were potentially reviewable, but only 36 (nine with quantitative tolerability reports, 20 with qualitative tolerability reports, and seven that only reported blinding) provided sufficient information to be included in the review. Quantitative information on tDCS tolerability and blinding maintenance in PwPD is scarce, and future reviews and metanalyses should carefully consider the possibility of placebo effects in their included studies.

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“…According to recent molecular studies, direct current stimulation produces significant changes in neurotrophic factors, especially on brain-derived neurotrophic factor (BDNF). Thus, variations in BDNF secretion correlated to recovery after direct stimulation in preoperative treatment of pain control and Parkinson's disease ( 27 , 28 ). Similarly, elevated nerve growth factor (NGF) serum levels in patients with depression have been suggested as adaptive neuroplasticity and associated with cognitive improvement after direct current stimulation ( 29 ).…”

Section: Discussionmentioning

confidence: 99%

Neuroplasticity and Epilepsy Surgery in Brain Eloquent Areas: Case Report

et al. 2020

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Introduction: Neuronal plasticity includes changes in any component of the central nervous system in response to intrinsic or extrinsic stimuli. Brain functions that depend on the epileptogenic cortex pose a challenge in epilepsy surgery because many patients are excluded from pre-surgical evaluation for fear of the possible sequelae. Some of these patients may be rescued by enhancing neuronal plasticity with brain neuromodulation techniques. Case Report: We describe a 6-year-old child with refractory focal motor seizures symptomatic to a neuroepithelial dysembryoblastic tumor in the left temporo-parietal region. He underwent limited resection of the lesion in order to avoid sequelae in his language function. A functional study at age of 17 years revealed an overlap of Wernicke's area with the tumor and areas of incipient language reorganization in the contralateral hemisphere. An invasive neuromodulation procedure was designed to enhance neuroplasticity. After craniotomy, he underwent language training and simultaneous electrical inhibition of language using an electrode grid placed over the lesion. The intensity of the language inhibitory stimulus was increased every day to force the use of accessory language areas in the right hemisphere by neuroplasticity. Results: The language of the patient improved for six consecutive days until he was able to speak and understand while undergoing maximum electrical inhibition. The tumor was resected using a cortical mapping guide. Discussion: Application of direct cortical stimulation techniques and language pre-habilitation before epilepsy surgery can be useful to rescue patients excluded from resective surgery, especially young patients with long-term lesions.

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Dopamine, BDNF and Motor Function Postbilateral Anodal Transcranial Direct Current Stimulation in Parkinson’s Disease

Abstract: Bilateral anodal tDCS is a safe stimulation protocol that leads to motor functions' improvement and BDNF serum level increase in patients with Parkinson's disease, however the findings of this feasible study are preliminary and further study is needed.

Cited by 17 publications

References 34 publications

tDCS-Enhanced Consolidation of Writing Skills and Its Associations With Cortical Excitability in Parkinson Disease: A Pilot Study

tDCS-Enhanced Consolidation of Writing Skills and Its Associations With Cortical Excitability in Parkinson Disease: A Pilot Study

Tolerability and Blinding of Transcranial Direct Current Stimulation in People with Parkinson’s Disease: A Critical Review

Neuroplasticity and Epilepsy Surgery in Brain Eloquent Areas: Case Report

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