Dopamine and serotonin contribute to Paecilomyces hepiali against chronic unpredictable mild stress induced depressive behavior in Sprague Dawley rats

Wang, Juan; Liu, Yange; Li, Lanzhou; Qi, Yidi; Zhang, Yuan‐Zhu; Li, Longtu; Teng, Lirong; Wang, Di

doi:10.3892/mmr.2017.7261

Cited by 13 publications

(8 citation statements)

References 36 publications

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“…Animal model experiments also confirm that hippocampal neurons in depressed rats are disordered and loose, the nuclei of hippocampal neurons are shrunken, the nuclear membrane is irregular and vague, and mitochondria are swelled and denatured ( 6 , 7 ). The etiology of depression is dominated by monoamine hypothesis, which suggests that the decrease of 5-hydroxy tryptamine, norepinephrine and dopamine functions is its pathological mechanism ( 8 ). Some studies have focused on the role of neuronal regeneration in the pathogenesis and treatment for depression.…”

Section: Introductionmentioning

confidence: 99%

MicroRNA-27a participates in the pathological process of depression in rats by regulating VEGFA

Cui¹,

Gong²,

Cao³

et al. 2018

Exp Ther Med

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The present study aimed to determine the expression of vascular endothelial growth factor A (VEGFA) and microRNA (miRNA/miR)-27a in hippocampal tissues, and serum from a depression model of rats. In addition, the present study aimed to understand the mechanism of regulation of miR-27a in depression. A total of 40 male rats were selected, and divided into the control and depression model groups. The rats in the model group were subjected to 14 types of stimulations to model depression. By determining the body weight, syrup consumption rate and open field test score, the extent of depression in the rats was evaluated. Quantitative-polymerase chain reaction was used to determine the expression of VEGFA mRNA and miR-27a in hippocampal tissues, and serum. ELISA was used to measure the content of VEGFA protein in serum, while western blotting was employed to determine the expression of VEGFA protein in hippocampal tissues. A dual luciferase assay was carried out to identify the interactions between VEGFA mRNA and miR-27a. The rats in the depression model group showed depression symptoms and the depression model was successfully constructed. Rats with depression had lower VEGFA mRNA and protein expression in the hippocampus, and peripheral blood compared with the control group. Rats in the depression model group had reduced levels of miR-27a in the hippocampus and peripheral blood, which may be associated with the levels of VEGFA. miR-27a was able to bind with the 3′-untranslated region of VEGFA mRNA to regulate its expression. The present study demonstrated that miR-27a expression in hippocampal tissues and blood from rats with depression is upregulated, while the expression of VEGFA mRNA and protein is downregulated. miR-27a may participate in the pathological process of depression in rats by regulating VEGFA.

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Section: Introductionmentioning

confidence: 99%

MicroRNA-27a participates in the pathological process of depression in rats by regulating VEGFA

Cui¹,

Gong²,

Cao³

et al. 2018

Exp Ther Med

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“…After such exposure, animals exhibited an emotional downturn, resulting in weight loss, total travelled distance reduction, reduction in frequency of grooming and rearing, and sucrose water preference decrease. Long-term treatment of Gl-E or uoxetine reversed rat mood and increased body weight and increased sucrose water preference in UCMS-induced rats [21].…”

Section: Discussionmentioning

confidence: 89%

Ganoderma Lucidum Ameliorated Depression-Like Behavior in an Unpredictable Chronic Mild Stress Rat Model Via Regulation of Monoamines

Cheng

2023

Preprint

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Purpose This study investigated antidepressant-like effect of Gl-E on rats exposed to UCMS and elucidated its potential mechanism of antidepressant action of Gl-E by detecting the levels of monoamines and their metabolites in the rats’ brains. Methods Sprague-Dawley rats were subjected to UCMS and treated with extract of G. lucidum (Gl-E) and fluoxetine (FLU) for 28 consecutive days. The sucrose preference test (SPT) and open field test (OFT) were applied to assess the antidepressant effects. The levels of monoamines including serotonin (5-hydroxytryptamine, 5-HT), norepinephrine (NE) and dopamine (DA) and their metabolites in the brain of rats were measured by HPLC. Results The results revealed that 4 weeks of UCMS exposure induced significant depression-like behavior, with low 5-HT, NE and DA levels in the rats’ brains. The treatment of Gl-E (0.1 and 0.5 g/kg) or FLU significantly alleviated the behavior deficiency and body weight reduction in UCMS rats. In addition, the levels of 5-HT, NE and DA in the brain of UCMS rats were increased after the Gl-E treatment. Conclusion The present study demonstrated that Gl-E could ameliorate depression-like behaviors in UCMS rats. Monoamines played an important role in the antidepressant action of Gl-E.

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“…The filtrate was filtered through a 0.22 mm filter membrane. Standard solutions were prepared at different concentrations (20,40,60,80, and 100 mg/L) using glucose standards, and standard curves were plotted to determine the polysaccharide content [31].…”

Section: Polysaccharide Determinationmentioning

confidence: 99%

“…This indicates that during the infection process, S. hepiali transforms part of the organic substances in the pupa into S. hepiali polysaccharides (SPs). As for SP, there have been many studies demonstrating its potential anti-diabetic nephropathy, anti-fatigue, hypoglycemic, anti-depressant, and anti-nociceptive properties [23,27,39,40]. A recent study on db/db mice showed that SP has pharmacological functions such as hypoglycemic, hypolipidemic, anti-diabetic, and anti-nephritic functions; the mechanism underlying this effect may be related to the Nrf2-meadited NF-κB signaling pathway in the mice [41].…”

Section: Polysaccharide Analysismentioning

confidence: 99%

“…anti-diabetic nephropathy, anti-fatigue, hypoglycemic, anti-depressant, and anti-nociceptive properties [23,27,39,40]. A recent study on db/db mice showed that SP has pharmacological functions such as hypoglycemic, hypolipidemic, anti-diabetic, and anti-nephritic functions; the mechanism underlying this effect may be related to the Nrf2-meadited NF-κB signaling pathway in the mice [41].…”

Section: Polysaccharide Analysismentioning

confidence: 99%

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Nutritional Profile Changes in an Insect–Fungus Complex of Antheraea pernyi Pupa Infected by Samsoniella hepiali

Wang

Meng

Wang

2023

Foods

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Historically, some edible insects have been processed into a complex of insect and fungus, such as Antherea pernyi and Samsoniella hepiali. Until now, the dynamics of the nutritional changes due to this infection were unclear. This study reveals the dynamic changes in nutritional components of Antherea pernyi pupa after infection with Samsoniella hepiali at post-infection time points of 0 d, 10 d, 20 d, and 30 d. The dynamic analysis of the components at different post-infection times showed that the content of polysaccharides and cordycepin increased with time while the content of fats and chitin decreased. The content of proteins showed a trend of decreasing at the beginning and then increasing. The essential amino acids (EAAs) decreased at the beginning and then increased, and non-essential amino acids (NEAA) changed similarly. The essential amino acid index showed a slight continuous decrease. Although the crude fat decreased dramatically due to the infection, from a value of 30.75% to 7.2%, the infection of S. hepiali produced five new fatty acids (14-methyl-pentadecanoic acid, docosanoic acid, succinic acid, arachidonic acid, and myristic acid) while the content of the seven fatty acids was greatly reduced after infection. Therefore, after being infected by S. hepiali and combined with it, the nutritional profile of A pernyi pupa was changed significantly and there were different characteristics at different infection stages. The above findings provide scientifically fundamental data to understand the nutritional value of the insect–fungus complex as human food and animal feed.

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Dopamine and serotonin contribute to Paecilomyces hepiali against chronic unpredictable mild stress induced depressive behavior in Sprague Dawley rats

Cited by 13 publications

References 36 publications

MicroRNA-27a participates in the pathological process of depression in rats by regulating VEGFA

MicroRNA-27a participates in the pathological process of depression in rats by regulating VEGFA

Ganoderma Lucidum Ameliorated Depression-Like Behavior in an Unpredictable Chronic Mild Stress Rat Model Via Regulation of Monoamines

Nutritional Profile Changes in an Insect–Fungus Complex of Antheraea pernyi Pupa Infected by Samsoniella hepiali

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