Dopamine and noradrenaline transport into subcellular vesicles of the striatum

Philippu, A.; Beyer, Jens

doi:10.1007/bf00501482

Cited by 62 publications

(14 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Based on these data, we have speculated (Kuczenski, 1983;Florin et al, 1994) as have others with regard to the sympathetic nervous system (Trendelenburg,199 l), that a releasing action by AMPH requires mobilization of vesicular NE into the cytoplasm, and several mechanisms have been postulated by which AMPH, particularly at higher doses, can produce NE mobilization (Johnson et al, 1982;Phillips, 1982;Sulzer and Rayport, 1990). In this regard, AMPH exhibits a lower IC,, in its interaction with the neuronal transporter than with the vesicular transporter (Schumann and Philippu, 1962;Philippu and Beyer, 1973;Ferris and Tang, 1979;Knepper et al, 1988). Thus, AMPH would be expected to effectively inhibit NE uptake at lower doses than required to mobilize vesicular NE for release.…”

Section: Discussionmentioning

confidence: 93%

Hippocampus norepinephrine, caudate dopamine and serotonin, and behavioral responses to the stereoisomers of amphetamine and methamphetamine

et al. 1995

View full text Add to dashboard Cite

Microdialysis in behaving animals was used to concomitantly characterize the dopamine and 5-HT responses in the caudate and the norepinephrine response in the hippocampus to the D- and L-isomers of amphetamine and methamphetamine. Doses of all four drugs which promoted similar stereotypy responses produced a D-amphetamine-like response profile of dopamine and dopamine metabolites, suggesting that all these drugs interact with dopamine systems to facilitate the release of transmitter. However, in contrast to the similar behavioral profiles, the magnitude of the dopamine responses diverged significantly. In addition, all four drugs increased extracellular norepinephrine and 5- HT, but the relative responses differed markedly from dopamine and from each other. The contrasting structure-activity relationships for these drugs likely reflect their differential potency at the various neuronal uptake transporters in promoting either transmitter release, and/or uptake blockade. In addition, the interaction of each drug at the vesicular transporters, as well as the availability of a cytoplasmic pool of transmitter likely also contribute to the neurotransmitter response. Because of the particularly divergent transmitter response profiles exhibited by L-methamphetamine, its behavioral and neurotransmitter effects were characterized over a more extended range of doses. Although the duration of the increase in extracellular dopamine was clearly proportional to dose, the dose-dependent increases in the magnitude of the dopamine response did not parallel the behavioral profiles. The results of these studies indicate that, while the dopamine, norepinephrine and 5-HT responses to these drugs probably contribute to the expression of stimulant-induced behaviors, simple relationships between the neurotransmitter responses and the behavioral profiles were not evident.

show abstract

Section: Discussionmentioning

confidence: 93%

Hippocampus norepinephrine, caudate dopamine and serotonin, and behavioral responses to the stereoisomers of amphetamine and methamphetamine

et al. 1995

View full text Add to dashboard Cite

show abstract

“…This short-term local feedback inhibition may be a result of changes in the state of tyrosine hydroxylase in the nerve terminal, which is presumably mediated by DA action on autoreceptors (Morgenroth et al, 1976;Walters and Roth, 1976). Furthermore, DA in the nerve terminals is normally stored in vesicles (Philippu and Beyer, 1973), whereas the major degradation of DA occurs in the extravesicular fractions (Broch and Fonnum, 1972;Russel et al, 1979). Thus, when a large amount of DA is present in the brain, the excessive DA could be readily metabolized to inactive compounds.…”

Section: Discussionmentioning

confidence: 99%

Short- and long-term effects ofl-dopa administration on striatal acetylcholinesterase activity

Messripour

Shahidi

1990

Molecular and Chemical Neuropathology

View full text Add to dashboard Cite

Exogenously applied dopamine may interfere with cholinergic activity in the brain. The aim of the present work was to study the effect of L-dopa administration on acetylcholinesterase (EC 3.1.1.7) activity in rat (Wistar) brain striatum. Short-term administration of a mixture of L-dopa (10 mg/kg) and carbidopa (1 mg/kg) resulted in an increase in dopamine content and a decrease in acetylcholinesterase activity of the tissue. The greatest changes were found 30 min postinjection, and activity returned to near-control values after 2 h. When the drug mixture was injected for a period of 30 d and the animals were killed 24 h after the last injection, a lower dopamine content and higher enzyme activity were seen, compared to control values. It would appear that chronic administration of L-dopa gradually reduced the dopamine-storage capacity of the striatum and that the activity of acetylcholinesterase might be controlled by the levels of dopamine in the brain striatum.

show abstract

“…In the past few years, new techniques for the isolation and characterization o f vesicles from neuronal tissues have been developed which permit studies to be performed similarly to those done originally in adrenomedullary vesi cles (39)(40)(41)46). The current review, in addi tion to summarizing results obtained in adrenal preparations, indicates that the use o f the adre nal medulla as a model o f neurons has been only partially valid, and that differences do exist in the catecholamine uptake properties of synaptic vesicles from neurons compared to adrenomedullary vesicles.…”

mentioning

confidence: 99%