Dopamine agonists and valvular heart disease

Cheung, Dianne S; Heaney, Anthony P.

doi:10.1097/med.0b013e32832d9f64

Cited by 11 publications

(4 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our database does not offer any information regarding the intake of dopamine agonists, which have been shown to induce valvular heart disease. 32 The diagnosis of diabetes itself or the higher rate of myocardial infarctions in the diabetes group might have led to an increased probability of seeing a cardiologist and receiving an echocardiogram and thus incidental detection of AS. Similarly, the fact that a guideline-compliant diagnosis of aortic valve stenosis was carried out is not documented for every single patient.…”

Section: Discussionmentioning

confidence: 99%

Diabetes mellitus is associated with an increased incidence of aortic valve stenosis

Roderburg

Loosen

Luedde

et al. 2021

Diabetes and Vascular Disease Research

View full text Add to dashboard Cite

Background: The prognosis of patients with diabetes mellitus (DM) is particularly determined by vascular comorbidities. A recent theory implies that DM could also promote aortic valve stenosis (AS). The present study investigates this association in a large collective of outpatients. Methods: This retrospective cohort study compared the incidence of AS in patients with an initial diagnosis of type 2 DM and a matched non-DM cohort in 809 general and diabetologist practices in Germany between January 2005 and December 2018. Cox regression models were performed to study the association between type 2 DM and AS incidence. Results: A total of 78,805 patients with type 2 DM and 78,805 patients without diabetes were analysed. Diabetes patients were more frequently diagnosed with obesity (52% vs 21%). Four percent of patients with and three percent of without diabetes were diagnosed with AS ( p < 0.001). Diabetes was significantly associated with an increased incidence of AS (HR: 1.36, p < 0.001). This association was higher in men (HR: 1.41) versus women (HR: 1.30). The strongest association was observed in young patients (18–50 years, HR: 2.35, p < 0.001). Conclusion: In our study, diabetes patients had a higher incidence of aortic stenosis during their disease course.

show abstract

Section: Discussionmentioning

confidence: 99%

Diabetes mellitus is associated with an increased incidence of aortic valve stenosis

Roderburg

Loosen

Luedde

et al. 2021

Diabetes and Vascular Disease Research

View full text Add to dashboard Cite

show abstract

“…Recent studies using high-dose D 2 -agonist therapy in Parkinson's disease patients have demonstrated cardiac valvular defects due to drug but in this Cushing's study, no patients developed deterioration of cardiac function, although one patient with a history of tricuspid regurgitation did develop worsening valvular function. 47 Of note, a majority of patients did experience improvement in hypertension and glucose intolerance, even in the absence of cortisol normalization. These findings renew interest in the potential use of dopamine agonists in Cushing's disease, although in many cases, high D 2 -agonist doses may be required.…”

Section: -Agonistsmentioning

confidence: 97%

Medical treatment of Cushing's disease: Overview and recent findings

Praw¹,

Heaney

2009

IJGM

Self Cite

View full text Add to dashboard Cite

Cushing's disease, due to pituitary adrenocorticotropic hormone (ACTH) hypersecretion, is the most common etiology of spontaneous excess cortisol production. The majority of pituitary tumors causing Cushing's disease measure 1 cm and the excess morbidity associated with these tumors is mostly due to the effects of elevated, nonsuppressible, ACTH levels leading to adrenal steroid hypersecretion. Elevated circulating cortisol levels lead to abnormal fat deposition, hypertension, diabetes, coronary artery disease, osteoporosis, muscle weakness and psychological disturbances. At experienced centers, initial surgical remission rate via transnasal, transphenoidal resection approaches 80% for tumors less than 1 cm, but may be as low as 30% for larger lesions and long-term recurrence in all groups approaches 25%. Residual disease may be managed with more radical surgery, pituitary-directed radiation, bilateral adrenalectomy, or medical therapy. This paper addresses current and novel therapies in various stages of development for Cushing's disease.

show abstract

“…It is recommended, if the dose of cabergoline is higher than 2 mg per week, that echocardiograms be performed periodically to monitor for heart valve abnormalities [8].…”

Section: Treatment Of Pituitary Adenomasmentioning

confidence: 99%

Mini review of the pathogenesis, incidence, and treatment of Pituitary adenomas

Andre Manov,

S. Chauhan

2023

World J. Adv. Res. Rev.

View full text Add to dashboard Cite

In this review article, we are discussing the origin of pituitary tumors. We are showing the pathological transcription factors playing role in the differentiation of the pituitary cells. We are also describing the regulation of pituitary hormone secretion, describing the incidence of pituitary tumors, and at length describe the modern treatment of them with surgery, medications, or stereotactic radiosurgery (gamma knife) as well as a combination of different treatment modalities.

show abstract

Dopamine agonists and valvular heart disease

Cited by 11 publications

References 25 publications

Diabetes mellitus is associated with an increased incidence of aortic valve stenosis

Diabetes mellitus is associated with an increased incidence of aortic valve stenosis

Medical treatment of Cushing's disease: Overview and recent findings

Mini review of the pathogenesis, incidence, and treatment of Pituitary adenomas

Contact Info

Product

Resources

About