Dopamine

Neff, Norton H.; Hadjiconstantinou, Maria; Lacković, Zdravko

doi:10.1007/978-1-4757-0310-8_7

Cited by 3 publications

(2 citation statements)

References 64 publications

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“…For example, activation of D 1 -like receptors located in blood vessels results in smooth muscle relaxation, 10 while stimulation of D 2 -like receptors on perivascular sympathetic nerves inhibits noradrenaline release with a subsequent decrease in blood pressure due to a fall in peripheral vascular resistance. 10 Likewise, some studies suggest that activation of D 3 receptor subtypes induced an endothelium-independent vasorelaxation, while costimulation of the D 1 and D 3 receptor subtypes resulted in an additive vasorelaxation. 11 Moreover, dopamine can also modulate (by presynaptic inhibition via the D 4 receptor subtype) primary Cand Aδ-fiber nociceptive (CGRPergic) sensory pathways.…”

Section: ■ Introductionmentioning

confidence: 99%

“…Notably, its contribution to the modulation of vascular tone and blood pressure depends mainly on the dopamine receptor (sub)types involved and their location. For example, activation of D 1 -like receptors located in blood vessels results in smooth muscle relaxation, while stimulation of D 2 -like receptors on perivascular sympathetic nerves inhibits noradrenaline release with a subsequent decrease in blood pressure due to a fall in peripheral vascular resistance . Likewise, some studies suggest that activation of D 3 receptor subtypes induced an endothelium-independent vasorelaxation, while costimulation of the D 1 and D 3 receptor subtypes resulted in an additive vasorelaxation .…”

Section: Introductionmentioning

confidence: 99%

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Activation of Dopamine D₃ Receptor Subtypes Inhibits the Neurogenic Systemic Vasodilation Induced by Stimulation of the Perivascular CGRPergic Discharge

Manrique-Maldonado¹,

Altamirano-Espinoza²,

Rivera‐Mancilla³

et al. 2019

ACS Chem. Neurosci.

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The sensory nervous system controls cardiovascular homeostasis via capsaicin-sensitive neurons that release calcitonin gene-related peptide (CGRP), which subsequently activates CGRP receptors. How this perivascular CGRPergic discharge is modulated, nevertheless, remains unclear. In pithed rats, systemic vasodilation induced by CGRPergic discharge stimulation results in diastolic blood pressure (BP) decrements that are inhibited by the dopamine D 2 -like receptor agonist quinpirole. Since this inhibition is mediated by raclopride-or haloperidol-sensitive D 2 -like receptors (comprising the D 2 , D 3 , and D 4 subtypes), the present study pharmacologically investigated the specific contribution of these subtypes to the modulation of the systemic CGRPergic vasodilation, using highly specific antagonists. To that end, 55 male Wistar rats were pithed for thoracic (T 9 −T 12 ) spinal stimulation of the perivascular CGRPergic discharge. The resulting frequency-dependent decrements in diastolic BP were inhibited by quinpirole, and this sensory-inhibition was (a) unchanged after i.v. injections of the antagonists L-741,626 (D 2 ) or L-745,870 (D 4 ) and (b) completely blocked by SB-277011-A (D 3 ). Accordingly, we suggest the main role of the D 3 receptor subtypes in the inhibition by quinpirole of the neurogenic CGRPergic systemic vasodilation. These findings contribute to a better understanding of the dopaminergic modulation of the rat perivascular CGRPergic discharge producing systemic vasodilation.

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Section: ■ Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Activation of Dopamine D₃ Receptor Subtypes Inhibits the Neurogenic Systemic Vasodilation Induced by Stimulation of the Perivascular CGRPergic Discharge

Manrique-Maldonado¹,

Altamirano-Espinoza²,

Rivera‐Mancilla³

et al. 2019

ACS Chem. Neurosci.

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Sources of Circulating Dopamine—A Personal View

Cuche¹

1988

Peripheral Actions of Dopamine

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Renal Dopaminergic Mechanisms and Hypertension: A Chronology of Advances

O’Connell

Aherne

2000

Clinical and Experimental Hypertension

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Dopamine (DA) has been shown to influence kidney function through endogenous synthesis and subsequent interaction with locally expressed dopamine receptor subtypes (D1, D5 as D1-like and D2, D3, and D4 as D2-like). DA, and DA-receptor specific agonists and antagonists can alter renal water and electrolyte excretion along with renin release when infused systemically or intrarenally. Such effects are brought about by a combination of renal hemodynamic and direct tubular effects evoked along the full length of the nephron. The cellular mechanisms that direct these dopamine-mediated renal electrolyte fluxes have recently been clarified and include alterations in adenylyl cyclase, phospholipase C, and phospholipase A1 activity. The dopaminergic system also interacts directly with the renal kallikrein-kinin, prostaglandin and other neurohumoral systems. Aberrant renal dopamine production and/or dopamine receptor function have been reported in salt-dependent and low-renin forms of human primary hypertension as well as in genetic models of animal hypertension, including the SHR and Dahl SS rat. DA D1 or D3 receptor knockout mice have been shown to develop hypertension.

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Dopamine

Cited by 3 publications

References 64 publications

Activation of Dopamine D₃ Receptor Subtypes Inhibits the Neurogenic Systemic Vasodilation Induced by Stimulation of the Perivascular CGRPergic Discharge

Activation of Dopamine D₃ Receptor Subtypes Inhibits the Neurogenic Systemic Vasodilation Induced by Stimulation of the Perivascular CGRPergic Discharge

Sources of Circulating Dopamine—A Personal View

Renal Dopaminergic Mechanisms and Hypertension: A Chronology of Advances

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Dopamine

Cited by 3 publications

References 64 publications

Activation of Dopamine D3 Receptor Subtypes Inhibits the Neurogenic Systemic Vasodilation Induced by Stimulation of the Perivascular CGRPergic Discharge

Activation of Dopamine D3 Receptor Subtypes Inhibits the Neurogenic Systemic Vasodilation Induced by Stimulation of the Perivascular CGRPergic Discharge

Sources of Circulating Dopamine—A Personal View

Renal Dopaminergic Mechanisms and Hypertension: A Chronology of Advances

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Activation of Dopamine D₃ Receptor Subtypes Inhibits the Neurogenic Systemic Vasodilation Induced by Stimulation of the Perivascular CGRPergic Discharge

Activation of Dopamine D₃ Receptor Subtypes Inhibits the Neurogenic Systemic Vasodilation Induced by Stimulation of the Perivascular CGRPergic Discharge