Dopamine 2 agonists for the management of type 2 diabetes: a systematic review and meta-analysis

Dereje, Beyene; Nardos, Aschalew

doi:10.1007/s40200-023-01230-4

Cited by 3 publications

(2 citation statements)

References 47 publications

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“…It is important to check regularly to detect diabetes-related health risks early, and maintaining healthy blood pressure, cholesterol, blood sugar level, HbA1c, and waist circumference levels is also essential. 18 , 21 Monitoring patients’ cognitive function, promoting vaccinations, caring for overweight patients, educating patients and caregivers, preventing comorbidities, and limiting the risk of repercussions are all part of managing diabetes mellitus. 6 , 17 …”

Section: Introductionmentioning

confidence: 99%

Antidiabetic Activities of 80% Methanol Extract and Solvent Fractions of Verbascum Sinaiticum Benth (Scrophulariaceae) Leaves in Mice

Dereje,

Nardos,

Abdela

et al. 2023

JEP

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Background Because of the scarcity, high cost, and severe side effects of current medications, it is necessary to discover novel, safe, and affordable anti-diabetic drugs. The current study was conducted to evaluate the antidiabetic activities of Verbascum sinaiticum Benth leaves in mice. Methods Leaf coarse powder was extracted with 80% methanol and then fractionated with n-hexane, ethyl acetate, and distilled water. The glucose-lowering effects of V. sinaiticum at 100, 200, and 400mg/kg were then studied. Glibenclamide was used as a positive control at a dose of 5 mg/kg. For oral glucose tolerance tests and hypoglycemia tests, Tween 2% was used as a negative control, while citrate buffer was used as a negative control for antihyperglycemic investigations. The results from the study were evaluated using one-way ANOVA, and then Tukey’s post hoc multiple comparison test was performed. Results Blood glucose levels were significantly reduced by the V. sinaiticum 80% methanol extract at 400 mg/kg (p<0.05). The blood glucose levels were significantly lowered by the aqueous residue at 400 mg/kg (p<0.05) and the ethyl acetate fractions at 200 mg/kg (p<0.01) and 400 mg/kg (p<0.001); however, none of the fraction extracts resulted in hypoglycemic shock in healthy mice. Higher glucose tolerance was seen in orally glucose-loaded mice after exposure to 80% methanol extracts at 200 and 400 mg/kg (p<0.05), the aqueous residual fraction at 200 mg/kg (p<0.01), and the ethyl acetate fraction at 200 and 400 mg/kg (p<0.05). The ethyl acetate fraction at 200 and 400 mg/kg (p<0.01), the 80% methanol extract at 400 mg/kg (p<0.05) and the aqueous residue at 400 mg/kg (p 0.01) significantly lowered blood glucose levels in streptozotocin-induced diabetic mice. Conclusion The results of this study revealed that the 80% methanol extract and solvent fractions of V. sinaiticum Benth leaves are endowed with antidiabetic activity.

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Section: Introductionmentioning

confidence: 99%

Antidiabetic Activities of 80% Methanol Extract and Solvent Fractions of Verbascum Sinaiticum Benth (Scrophulariaceae) Leaves in Mice

Dereje,

Nardos,

Abdela

et al. 2023

JEP

Self Cite

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“…They have demonstrated efficacy in conditions such as Cushing's disease and acromegaly, wherein they contribute to the reduction of cortisol and IGF-1 levels, potentially facilitating metabolic improvements (21)(22)(23)(24). Furthermore, it is crucial to underscore the significance of considering the effects of DAs on diabetes regulation and hypertension control independently of hormonal levels (25)(26)(27). Namely, it has been shown that increased D2RS protein expression in subcutaneous adipose tissue during hyperglycemia and T2D, coupled with dopamine receptor agonists' inhibition of adipocyte beta-adrenergic stimulation of lipolysis, may explain the observed positive effects on lipid metabolism in patients treated with bromocriptine (28).…”

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confidence: 99%

Commentary: Clinical characteristics of male prolactinoma patients mainly presenting with severe obesity and the metabolic response to dopamine agonist therapy

Andereggen,

Christ

2024

Front. Endocrinol.

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Acquired hypoprolactinemia in men, possible phenotype

Corona,

Rastrelli,

Sparano

et al. 2024

Rev Endocr Metab Disord

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The physiological role of prolactin (PRL) in men is still not well defined. The pathological increase is characterized by sexual function impairment along with possible negative consequences in body composition and metabolic profile. Conversely, the clinical significance of reduced PRL levels was only partially investigated or mainly neglected. The present paper aims to summarize and critically discuss possible phenotypes characterizing male subjects with reduced PRL levels. When possible, meta-analytic results were provided. Available data derived from patients seeking medical care for sexual dysfunction as well as from cross-sectional and longitudinal studies showed that low PRL in males is associated with a worse metabolic phenotype (including diabetes mellitus), mood disturbances (including anxiety and depression), and sexual dysfunctions (including psychogenic erectile and ejaculatory dysfunctions). Whether or not these features are direct consequences of reduced PRL levels or whether the latter reflect other pathway impairments such as serotoninergic failure cannot be clarified. The present data, however, emphasize that a deficiency of PRL should be taken into account and need further investigations.

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Dopamine 2 agonists for the management of type 2 diabetes: a systematic review and meta-analysis

Cited by 3 publications

References 47 publications

Antidiabetic Activities of 80% Methanol Extract and Solvent Fractions of Verbascum Sinaiticum Benth (Scrophulariaceae) Leaves in Mice

Antidiabetic Activities of 80% Methanol Extract and Solvent Fractions of Verbascum Sinaiticum Benth (Scrophulariaceae) Leaves in Mice

Commentary: Clinical characteristics of male prolactinoma patients mainly presenting with severe obesity and the metabolic response to dopamine agonist therapy

Acquired hypoprolactinemia in men, possible phenotype

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