Dopahyperglykämie

Holtz, Peter; Credner, Karl; Strübing, Christel

doi:10.1515/bchm2.1944.280.1-2.9

Cited by 14 publications

(3 citation statements)

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“…L-Dihydroxyphenylalanine (levodopa) has been known for some time to induce hyperglycemia in animals. 16 Dopamine, which is produced by the decarboxylation of levodopa, is the agent responsible for this hyperglycemic effect. 13 In human beings, the intravenous administration of dopamine elevates blood glucose 17 ,23 and plasma free fatty acids (FF A) 26 but to a much lesser degree than does epinephrine.…”

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confidence: 99%

Glucose, insulin, and free fatty acid metabolism in Parkinson's disease treated with levodopa

Woert

Mueller

1971

Clin Pharma and Therapeutics

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Metabolism of carbohydrate and insulin was evaluated in 24 patients with Parkinson's disease before and during L‐dihydroxyphenylalanine (levodopa) therapy. In the untreated state these patients had low rates of glucose utilization (k) and impaired release of insulin during an intravenous glucose tolerance test (GTT). These abnormalities could not be related to age, diet, or degree of neurological disability. In addition these untreated patients had high fasting serum glucose and free fatty acid (FFA), normal human growth hormone (HGH), and low fasting serum insulin levels. It is proposed that the primary abnormality in carbohydrate‐insulin metabolism observed in these parkinsonian patients is a deficit in pancreatic insulin release. Levodopa treatment did not alter the low k and impaired insulin release. A trend toward more normal fasting serum levels of glucose, insulin, and FFA during levodopa therapy was suggested.

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confidence: 99%

Glucose, insulin, and free fatty acid metabolism in Parkinson's disease treated with levodopa

Woert

Mueller

1971

Clin Pharma and Therapeutics

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“…L-dopa has been known for some time to induce hyperglycemia in animals (Holtz and Credner, 1944) and dopamine is the agent responsible for this hyperglycemic effect (Hakanson et al, 1967). In human beings, the intravenous administration of dopamine elevates blood glucose (Horwitz et al, 1962;Mueller and Horwitz, 1962) and plasma free fatty acid (Pilkington et al, 1966) but to much lesser degree than does epinephrine.…”

Section: Discussionmentioning

confidence: 99%

Effect of L-Dopa on Anterior Pituitary Hormone Release in Man

et al. 1972

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“…Histidine.-The decarboxylation of I-histidine to histamine follow ing parenteral administration to guinea pigs is reported by Holtz & Credner (72). The kidney is considered to be the chief site of this conversion by the authors.…”

Section: Individual Amino Acidsmentioning

confidence: 92%

The Metabolism of Proteins and Amino Acids

Cohen¹

1945

Annu. Rev. Biochem.

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Dopahyperglykämie

Cited by 14 publications

References 0 publications

Glucose, insulin, and free fatty acid metabolism in Parkinson's disease treated with levodopa

Glucose, insulin, and free fatty acid metabolism in Parkinson's disease treated with levodopa

Effect of L-Dopa on Anterior Pituitary Hormone Release in Man

The Metabolism of Proteins and Amino Acids

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