Dopa-sensitive and Dopa-resistant gait parameters in Parkinson's disease

Blin, Olivier; Ferrandez, Anne-Marie; Pailhous, Jean; Serratrice, G

doi:10.1016/0022-510x(91)90283-d

Cited by 250 publications

(190 citation statements)

References 22 publications

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“…Levodopa intake increases velocity, stride length, and decreases the duration of the double limb support [2, 7-8, 14, 16, 19, 23, 34, 37]. However, after the administration of levodopa, cadence was increased in some reports [19] and not changed in the others [7,34] as in our study. Chronic bilateral STN stimulation improves akinesia, rigidity and tremor in patients with severe PD [21,[24][25][26][27][29][30].…”

Section: Discussioncontrasting

confidence: 38%

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Effect of bilateral subthalamic nucleus stimulation on parkinsonian gait

Xie¹,

Krack²,

Benabid

et al. 2001

Journal of Neurology

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Section: Discussioncontrasting

confidence: 38%

“…The fundamental problem in gait disturbance of PD is regulation of stride length [31]. Levodopa increases stride length and velocity (kinematic parameters), while temporal parameters related to rhythm are levodopa resistant [7].…”

Section: Introductionmentioning

confidence: 99%

Effect of bilateral subthalamic nucleus stimulation on parkinsonian gait

Xie¹,

Krack²,

Benabid

et al. 2001

Journal of Neurology

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“…Gait variability may help to enhance the early identification of potential fallers in PD, as it does in other populations. A few studies have observed increased variability in patients with PD compared to controls, noting that this variability tends to increase with disease severity (Blin et al, 1990;Blin, Ferrandez, Pailhous, & Serratrice, 1991;Hausdorff et al, 1998). In general, however, the relationships between gait variability, fall risk, and other parkinsonian features were not wellstudied and the effect of levodopa on falls and gait variability were also largely unknown.…”

Section: Gait Variability and Fall Risk In Parkinson's Disease (Pd)mentioning

confidence: 99%

Gait dynamics, fractals and falls: Finding meaning in the stride-to-stride fluctuations of human walking

Hausdorff

2007

Human Movement Science

712

594

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Until recently, quantitative studies of walking have typically focused on properties of a typical or average stride, ignoring the stride-to-stride fluctuations and considering these fluctuations to be noise. Work over the past two decades has demonstrated, however, that the alleged noise actually conveys important information. The magnitude of the stride-to-stride fluctuations and their changes over time during a walk -gait dynamics -may be useful in understanding the physiology of gait, in quantifying age-related and pathologic alterations in the locomotor control system, and in augmenting objective measurement of mobility and functional status Indeed, alterations in gait dynamics may help to determine disease severity, medication utility, and fall risk, and to objectively document improvements in response to therapeutic interventions, above and beyond what can be gleaned from measures based on the average, typical stride. This review discusses support for the idea that gait dynamics has meaning and may be useful in providing insight into the neural control of locomtion and for enhancing functional assessment of aging, chronic disease, and their impact on mobility.

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“…Regarding parkinsonian signs, patients with Parkinson's disease (PD) manifest slower gait velocity due to a reduction of step length with an unchanged cadence (Stolze et al 2001). While some of these gait disturbances are dopa-sensitive, others are dopa-resistant (Blin et al 1991), suggesting alternative or additional mechanisms than just dopamine deficiency. However, the relationship between quantitative gait parameters and individual MPS in aging is not known at present.…”

Section: Introductionmentioning

confidence: 99%

Contributions of mild parkinsonian signs to gait performance in the elderly

Allali

Mahoney

2014

AGE

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Mild parkinsonian signs (MPS) and gait abnormalities are common in aging, but the association between MPS and objective gait measures is not established in the elderly. This study aims to identify the link between MPS and quantitative gait measures, as well as to determine the pathogenesis of MPS in nondemented community-dwelling older adults without idiopathic Parkinson's disease or other parkinsonian syndromes. Three hundred seventy-four non-demented older adults (mean age, 76.44±6.71 years, 57 % women) participated in this study, where comprehensive neurological and medical assessments were conducted. We defined MPS based on the presence of any one of bradykinesia, rigidity, or rest tremor. Velocity and spatial, temporal, and variability gait parameters were recorded using an instrumented walkway. The associations of MPS and gait parameters as well as the relationship of individual MPS with medical illnesses were assessed with linear regressions controlling for key covariates. Participants with MPS walked slower and with disturbed spatial and variability components of gait compared to those without MPS. Bradykinesia was associated with worse spatial and variability gait parameters. This association was only significant for axial bradykinesia, but not for the presence of bradykinesia in the limbs. Cerebrovascular disease (β=.20, p<.01) was associated with bradykinesia, whereas cardiovascular disease (β=.15, p<.05) was associated with rigidity. Among MPS, bradykinesia but not rigidity or tremor was associated with worse quantitative gait performance in older adults. Cerebrovascular disease, a preventable condition, was specifically associated with bradykinesia.

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Dopa-sensitive and Dopa-resistant gait parameters in Parkinson's disease

Cited by 250 publications

References 22 publications

Effect of bilateral subthalamic nucleus stimulation on parkinsonian gait

Effect of bilateral subthalamic nucleus stimulation on parkinsonian gait

Gait dynamics, fractals and falls: Finding meaning in the stride-to-stride fluctuations of human walking

Contributions of mild parkinsonian signs to gait performance in the elderly

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