Dopa-positive cells and melanin in basal cell epithelioma (BCE)

Deppe, Roland; Pullmann, H; Steigleder, G. K.

doi:10.1007/bf00561183

Cited by 22 publications

(9 citation statements)

References 11 publications

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“…The present ultrastructural study of pigmented BCCs has revealed alterations of melanocytes more extensive than that previously reported. 6–9,13–16 The ultrastructural morphometric findings obtained from this study confirmed, as expected, a statistically significant increase in melanocyte nuclear and cell area, nuclear and cell perimeter, and cell major diameter in the pigmented areas compared with the perilesional normal controls. The melanocytes in the pigmented areas exhibited hyperactivity of melanogenesis, and a degree of proliferation as shown by the presence of centrioles, in agreement with previous studies.…”

Section: Discussionsupporting

confidence: 84%

“…Maloney et al 4 confirmed that the melanocytes were large and had hypertrophied dendritic processes in 90% pigmented BCCs, using Fontana‐Masson staining. Deppe et al 6 demonstrated that the melanocytes were localized predominantly in the periphery of the BCC, using the Dopa‐reaction. When the proportion of melanocytes exceeded 5%, they were also observed in the central parts of tumors, a phenomenon described as melanocyte colonization.…”

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confidence: 99%

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Sub‐populations of melanocytes in pigmented basal cell carcinoma: a quantitative, ultrastructural investigation

et al. 2001

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These findings suggest that different populations of melanocytes are probably present in pigmented BCCs, and repeated cycles of phagocytosis of melanosome-containing apoptotic cells may represent the predominant way of forming large melanosome complexes. The present morphological observation and quantitative analysis provide a morphological basis for further studies to interpret other pathologic changes in pigmented BCCs.

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Section: Discussionsupporting

confidence: 84%

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confidence: 99%

Sub‐populations of melanocytes in pigmented basal cell carcinoma: a quantitative, ultrastructural investigation

et al. 2001

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“…In the white races, the frequency of pigmented BCC varies from 6.7% to 33% (19,20). As in the previous studies (20,21), pigment was located in superficial tumor islands more commonly than in deep ones. A notable finding was that only 28.6% (2 out of 7) of the fibrosing type was microscopically pigmented, in contrast to 100% (4 out of 4) in the adenoid type, 72.3% (34 out of 47) in the solid type, and 66.7% (6 out of 9) in the superficial type.…”

Section: Discussionsupporting

confidence: 50%

Clinical and Histopathological Characteristics of Basal Cell Carcinoma in Korean Patients

Cho

Kim

Whang

et al. 1999

The Journal of Dermatology

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Seventy-eight Korean patients with basal cell carcinoma (BCC) between 1984 and 1998 were retrospectively examined at Ewha Womans University Tongdaemun Hospital, Seoul, Korea. We analyzed the annual incidence, age and sex distribution, site of the lesions, clinical appearance, including the proportion of clinically pigmented tumors, modalities of treatment, incidence of recurrence and metastasis of the tumors, the histopathological patterns, and whether solar elastosis, microscopic pigmentation, or adamantinoid feature were associated. The male-to-female ratio was 0.902, and the average age of the patients at first examination was 58.2 years. Eighty percent of the tumors occurred on the head and neck, most commonly on the nose (26.9%), followed by the cheek, eyelid, and upper lip. Ulcerated nodules were the most common clinical presentation. Clinically, 55% of the tumors were pigmented. Six tumors recurred; none metastasized. Surgical excision was the most common modality of treatment. The most frequent histopathological pattern was the solid type (60.3%), followed by the superficial (11.5%) and fibrosing (9.0%) types. The occurrence of the superficial type was significantly associated with truncal lesions (p < 0.001). Solar elastosis was present in 62.1% of the tumors on the head and neck, compared with 8.3% in those of the trunk and limbs (p < 0.001), indicating the significance of sun exposure in the pathogenesis of BCC on exposed areas. Microscopic pigmentation was seen in 69.2% of the tumors. The focal adamantinoid feature was found in 14.1%, which is much higher than the previously reported incidence.

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“…These are also derived from non-neoplastic melanocytes which become incorporated within these tumors. 11,12 Differentiation of these pigmented tumors is usually not a problem because the cells in these tumors contain tonofilaments and desmosomes while in melanoma these features are absent. The tumor was located in the orbital region of a five-year-old girl and by light microscopy was suspected to be a rhabdomyosarcoma, although no cross striation was demonstrable.…”

Section: Diagnosis Of Malignant Melanomamentioning

confidence: 99%