Donovanosis in Central India: A Series of Six Cases and Review of Literature

Hajare, Sumit A; Mukhi, Jayesh; Rambhia, Kinjal Deepak; Singh, Rajesh

doi:10.7860/jcdr/2019/39500.12790

Cited by 3 publications

(4 citation statements)

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“…The healing time in the HIV-negative cases was 4 weeks whereas it ranged from 8 to 18 weeks in HIV-positive subjects. [ 8 ] In a case of granuloma inguinale with HIV infection reported by Marfatia et al ., the smear was negative (may be due to topical antimicrobials) but a biopsy clinched the diagnosis. Interestingly, the patient was not responding to azithromycin, aminoglycosides, minocycline, but completely responded to high-dose co-trimoxazole therapy (double strength tablet three times a day) suggesting possible resistance to those antimicrobials on clinical ground.…”

Section: Discussionmentioning

confidence: 99%

Multiple sexually transmitted infections as a presenting feature of human immunodeficiency virus/AIDS

Talati,

Marfatia,

Mahajan

2024

Indian Journal of Sexually Transmitted Diseases and AIDS

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A 45-year-old married male presented with nonhealing, painless ulcers with purulent discharge over genitals for 3 months. He had molluscum contagiosum over genitalia and forehead. A tissue smear suggested a diagnosis of donovanosis. Biopsy suggested diagnosis of molluscum contagiosum and serology was positive for human immunodeficiency virus 1 and herpes simplex 2. The patient was started on acyclovir and doxycycline. Antiretroviral therapy was initiated. The patient responded slowly over a period of 8 weeks. Immunocompromised patients having nonhealing genital ulcers must be subjected to tissue smear to pick up the diagnosis of granuloma inguinale.

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Section: Discussionmentioning

confidence: 99%

Multiple sexually transmitted infections as a presenting feature of human immunodeficiency virus/AIDS

Talati,

Marfatia,

Mahajan

2024

Indian Journal of Sexually Transmitted Diseases and AIDS

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“…High-risk sexual behavior among all cases including exposure to commercial sex workers and history of sexual exposure in endemic regions were probable causes in these cases. [ 44 ]…”

Section: Introductionmentioning

confidence: 99%

“…In women, the areas commonly affected include the labia minora, vaginal furcula, and, occasionally, the cervix and upper genital tract, where they can simulate carcinomas. [ 44 ] In 90% of cases, the genitals are affected but inguinal region may be involved in 10%. [ 19 ]…”

Section: Introductionmentioning

confidence: 99%

Genital ulcer disease: A review

Dhawan

Ahmed

Rawre

et al. 2022

Journal of Family Medicine and Primary Care

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Genital ulcer disease (GUD) continues to be an important cause of morbidity and mortality worldwide. It is an important risk factor for the acquisition of HIV. GUD is mainly caused by five sexually transmitted infections. Three pathogens most frequently associated with GUD are herpes simplex virus 2 (HSV-2), Treponema pallidum , and Haemophilus ducreyi . Although their prevalence varies among different geographical regions, HSV-2 is the leading cause of this syndrome globally. In recent years, there has been an epidemiological transition of HSV-1 with a growing role of this virus as a causative agent of GUD. GUD may present with unique features depending on the etiological agent that can help clinicians identify the etiology and start treatment. However, owing to atypical presentations and co-infections, an accurate clinical diagnosis is often a challenge without confirmatory laboratory tests. Standard methods used to detect the causative pathogens of GUD have limitations. Molecular methods can provide a more sensitive and rapid microbiological diagnosis, with detection of the pathogen from the clinical sample directly. In situations where no laboratory support is available, the syndromic approach for management should be followed. The current scenario, clinical presentation (typical and atypical), laboratory diagnosis, and management of GUD will be discussed in this review. We searched PubMed literature and Google search engine using the terms “genital ulcer disease,” “epidemiology of genital ulcer disease,” and “clinical features of genital ulcer disease and atypical presentations” and relevant literature was selected to provide current perspectives of GUD.

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“…6 The incidence of GI has decreased and is rarely found, but there are still reports of GI cases in endemic areas, including Papua New Guinea, India, Brazil, Australia, and South Africa. 7 The complete eradication of GI was accomplished,…”

Section: Introductionmentioning

confidence: 99%

Granuloma Inguinale

Purwoko

Devi

et al. 2021

Bioscmed

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Granuloma ingunale (GI) or donovanosis is a genital ulcer disease caused by theCalymmatobacterium granulomatis. It is a Gram-negative, facultative, obligateintracellular and pleomorphic bacterium. This bacterium has phylogeneticallyclosed to and placed within the Klebsiella genus. Clinically, the disease is com-monly characterized as painless, slowly progressive ulcerative lesions on thegenitals or perineum without regional lymphadenopathy. The lesions are highlyvascular and bleed easily on contact Extragenital lesions may occur but are rareand more common in newborns from mothers with GI genital lesions. Thisdisease is often neglected, therefore it is often misdiagnosed and inaccuratetherapy. Treatment time is 3 weeks or until clinical cure has been achieved forall proposed regimens. It often occurs both in men and women of reproductiveage (20-40 years). This article consists of several theoretical references that havebeen viewed to have a better understanding of GI.

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Donovanosis in Central India: A Series of Six Cases and Review of Literature

Cited by 3 publications

References 0 publications

Multiple sexually transmitted infections as a presenting feature of human immunodeficiency virus/AIDS

Multiple sexually transmitted infections as a presenting feature of human immunodeficiency virus/AIDS

Genital ulcer disease: A review

Granuloma Inguinale

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