Donors Older Than 70 Years in Liver Transplantation

Donor Age-Based Analysis of Liver Transplantation Outcomes: Short- and Long-Term Outcomes Are Similar Regardless of Donor Age

“…The expanded criteria donor designation carries with it the assumption that patient and graft survival may be inferior to the standard criteria donor, although this assumption has not been conclusive in the setting of liver transplantation. 8,9,12,13,18 Specifically, although some large national datasets suggest that specific factors associated with expanded criteria donors may be associated with inferior results, single-center studies investigating such factors have demonstrated acceptable and equivalent results to those found from standard criteria donors. So, the use of such "marginal donors," including those of advanced age, has been controversial and remains in evolution.…”

“…8,9,16,17,25,[30][31][32][33] In a study of liver preservation injury, Briceno and coauthors 16 identified 5 variables from marginal donors (moderate to severe fatty infiltration, prolonged ICU hospitalization, prolonged CIT, high doses of inotropic drugs, and older donors) that could be strictly correlated with development of moderate to severe preservation injury, with good accuracy. Donor age and CIT were independent predictors of increasing liver preservation injury.…”

“…2 In an effort to expand available organs for liver transplantation, many transplant centers are looking beyond the traditional "ideal" donor, to include the use of marginal or extended criteria donor organs, including the use of grafts from older donors. [4][5][6][7][8][9][10] The ideal donor is one who lacks characteristics that would place the graft at risk for primary nonfunction or early failure. This has typically been described as a brain dead donor, less than 40 years old, hemodynamically stable, with acceptable liver function and electrolytes.…”

Donor Age Affects Liver Regeneration during Early Period in the Graft Liver and Late Period in the Remnant Liver after Living Donor Liver Transplantation

“…The use of older donor grafts might lead to unfavorable recipient outcomes in both DDLT [3][4][5]7] and LDLT [10,31]. However, in studies of right lobe LDLT from highvolume centers, there were no significant differences in the survival rates of recipient from older and younger donor groups [11,26,33].…”

Liver Transplantation for Alcohol-Related Cirrhosis: A Single Centre Long-Term Clinical and Histological Follow-Up

“…This finding raises the question as to whether organs of aged donors, who would be considered unacceptable for most LT recipients, may in fact provide adequate liver function for these ALD patients. Some centres have published excellent results for donor organs up to the age of 80 years and more [19][20][21][22][23]. However, we know that organs from older donors are more susceptible to ischemia-reperfusion injury, and these grafts do worse in patients with high MELD scores [24][25][26].…”