Donor-to-recipient transmission of factor XII deficiency by orthotopic liver transplantation

Elsiesy, Hussien; Shawakat, Mohamed; Al–Hamoudi, Waleed; Al-Sebayel, M.; Renz, John F.; Elbeshbeshy, Hany; Abdelfattah, Mohamed Rabei; Abaalkhail, Faisal

doi:10.1080/08998280.2019.1641041

Cited by 1 publication

(1 citation statement)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Human coagulation (FXII) is a serine protease precursor, mainly synthesized by the liver ( Zhang et al, 2019 ). Its deficiency is an rare autosomal recessive trait associated with the prolongation of partial thromboplastin time (PTT), without increased risk of bleeding though the thrombophilic tendency (venous thromboembolism and myocardial infarction) ( Elsiesy et al, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

Factor XII deficiency in asymptomatic Saudi population: A retrospective cohort study

AlQahtany

Algahtani

Alshebly

et al. 2021

Saudi Journal of Biological Sciences

View full text Add to dashboard Cite

Factor XII (FXII) deficiency is a rare genetic blood disorder. It can lead to a higher risk of developing deep vein thrombosis or acquired thrombotic disorders than the general population. This retrospective study evaluated patients who opted for surgery and were found to have abnormal clotting profiles and clotting factors on preoperative routine blood. Patients were included regardless of whether they were symptomatic or asymptomatic. The cohort comprised 115 patients with a mean FXII level of 128.04 ± 36.93%. Two (1.79%) patients, both of whom were women, had FXII levels <60%. The mean FXII level was 58 ± 1.41 (range, 57–59%) in this group. The present study shows the prevalence of FXII in the asymptomatic Saudi population. The results provide the normal range for FXII. The findings of our study provide the basis for diagnosing F XII deficiency in the asymptomatic Saudi population.

show abstract

Section: Introductionmentioning

confidence: 99%