Donor to Host Transmission of Infection in Lung Transplantation

Wainstein, Esteban Javier; Smud, Astrid; Mañez, Noelia; Orazi, María Laura; Barcán, Laura; Svetliza, Graciela; Quinteros, Carlos M.; Dietrich, Alexander; Lozzo, Alejandro Gabriel Da; Beveraggi, Enrique; Smith, David; Castro, Horacio Matías

doi:10.1016/j.healun.2019.01.796

Cited by 1 publication

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“…Bunsow et al reported 2.1%, 49%, and 23.3% of positive cultures accordingly [ 6 ]. Different outcomes were reported by Wainstain et al with 12.7%, 83.6%, and 76.4% of positive cultures, respectively [ 7 ].…”

Section: Discussionmentioning

confidence: 87%

“…Nevertheless, it results in significant morbidity and mortality of recipients [ 20 ]. A study by Weinstein et al did not show any transmission of infection associated with donor bacteremia or contamination of the preserving fluid, but 13% of lung recipients developed an infection associated with graft colonization, which was associated with inadequate antibiotic therapy [ 7 ]. Other studies concerning LuTx showed transmission of infection in 3–14% of positive donor bronchial aspirate cultures and a related mortality of 0–14% of infected recipients [ 5 , 6 , 7 ].…”

Section: Discussionmentioning

confidence: 99%

“…A study by Weinstein et al did not show any transmission of infection associated with donor bacteremia or contamination of the preserving fluid, but 13% of lung recipients developed an infection associated with graft colonization, which was associated with inadequate antibiotic therapy [ 7 ]. Other studies concerning LuTx showed transmission of infection in 3–14% of positive donor bronchial aspirate cultures and a related mortality of 0–14% of infected recipients [ 5 , 6 , 7 ]. The transmission of pathogens in our analysis was much more frequent as it concerned 20% of positive cultures of the graft endobronchial swab, but only one recipient died from the infection.…”

Section: Discussionmentioning

confidence: 99%

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Analysis of Donor to Recipient Pathogen Transmission in Relation to Cold Ischemic Time and Other Selected Aspects of Lung Transplantation—Single Center Experience

et al. 2023

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Background: Infections are one of the leading causes of death in the early postoperative period after lung transplantation (LuTx). Methods: We analyzed 59 transplantations and culture results of the donor bronchial aspirates (DBA), graft endobronchial swabs (GES), and recipient cultures (RC) before and after the procedure (RBA). We correlated the results with a cold ischemic time (CIT), recipient intubation time, and length of stay in the hospital and intensive care unit (ICU), among others. Results: CIT of the first and second lungs were 403 and 541 min, respectively. Forty-two and eighty-three percent of cultures were positive in DBA and GES, respectively. Furthermore, positive results were obtained in 79.7% of RC and in 33.9% of RBA. Longer donor hospitalization was correlated with Gram-negative bacteria isolation in DBA. Longer CIT was associated with Gram-positive bacteria other than Staphylococcus aureus in GES and it resulted in longer recipient stay in the ICU. Furthermore, longer CIT resulted in the development of the new pathogens in RBA. Conclusion: Results of GES brought more clinically relevant information than DBA. Donor hospitalization was associated with the occurrence of Gram-negative bacteria. Positive cultures of DBA, GES, and RBA were not associated with recipient death.

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Section: Discussionmentioning

confidence: 87%