2017
DOI: 10.1007/s00167-017-4516-8
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Donor-site morbidity after osteochondral autologous transplantation for osteochondritis dissecans of the capitellum: a systematic review and meta-analysis

Abstract: PurposeTo determine the rate of donor-site morbidity after osteochondral autologous transplantation (OATS) for capitellar osteochondritis dissecans.MethodsA literature search was performed in PubMed/MEDLINE, Embase, and Cochrane Library to identify studies up to November 6, 2016. Criteria for inclusion were OATS for capitellar osteochondritis dissecans, reported outcomes related to donor sites, ≥10 patients, ≥1 year follow-up, and written in English. Donor-site morbidity was defined as persistent symptoms (≥1 … Show more

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Cited by 68 publications
(65 citation statements)
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“…For unstable fragmented lesions, this typically includes debridement of the lesion, removal of loose bodies, and concomitant marrow stimulation with abrasion chondroplasty or microfracture [30•, 31-35]. Alternatively, several open and arthroscopic techniques exist for lesion repair with fragment [24] fixation as well as restorative procedures such as osteochondral autografting and allografting and cellularinduced cartilage scaffolds [36][37][38][39][40][41][42].…”
Section: Surgical Managementmentioning
confidence: 99%
“…For unstable fragmented lesions, this typically includes debridement of the lesion, removal of loose bodies, and concomitant marrow stimulation with abrasion chondroplasty or microfracture [30•, 31-35]. Alternatively, several open and arthroscopic techniques exist for lesion repair with fragment [24] fixation as well as restorative procedures such as osteochondral autografting and allografting and cellularinduced cartilage scaffolds [36][37][38][39][40][41][42].…”
Section: Surgical Managementmentioning
confidence: 99%
“…3D tissue engineering composite biomaterials constructed in vitro can be used to repair, maintain, or improve the damaged tissue by transplanting them into the lesion site . Autologous transplantation is called the “golden standard” of clinical repair treatment, but its small repair area, high secondary incidence of donor area, and insufficient donor sources have been restricting the large‐scale clinical application of autologous transplantation . Tissue engineering not only provides a new therapeutic option to relieve the patient's pain, but more importantly, it overcomes the above difficulties and may be a viable alternative to regenerative therapy close to the gold standard .…”
Section: Introductionmentioning
confidence: 99%
“…This can lead to abnormal stress concentrations at the interface with resultant instability of the graft and poor long-term outcome (Friedman et al, 1985;Kurosaka et al, 1987;Lu and Jiang, 2006;Robertson et al, 1986). Grafts pose their own problems: autografts can result in significant donor site morbidity, and allografts and xenografts carry risks of immunogenicity and disease transmission (Bexkens et al, 2017;Martin et al, 1998;Patience et al, 1997;Puga Yung et al, 2017). As a result, the recapitulation of the native interface through tissue engineering perhaps represents the most promising strategy for successful repair of these complex tissues.…”
Section: Introductionmentioning
confidence: 99%