Donor aKIR genes influence the risk of EBV and CMV reactivation after anti‐thymocyte globulin‐based haploidentical hematopoietic stem cell transplantation
Fei Gao,
Zhuoyue Shi,
Jimin Shi
et al.
Abstract:Hematopoietic stem cell transplantation (HSCT) offers the highest curative potential for patients with hematological malignancies. Complications including infection, graft‐versus‐host disease (GVHD), and relapse reflect delayed or dysregulated immune reconstitution. After transplantation, NK cells rapidly reconstitute and are crucial for immune surveillance and immune tolerance. NK cell function is tightly regulated by killer immunoglobin‐like receptors (KIRs). Previous studies have revealed that donor KIRs, e… Show more
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