Donor Quality of Life After Living Donor Liver Transplantation: Single-Institute Experience

Toyoki, Yoshikazu; Ishido, Keinosuke; Kudo, Daisuke; Umehara, Minoru; Kimura, Norihisa; Narumi, S.; Sugai, Michihiro; Hakamada, Kenichi

doi:10.1016/j.transproceed.2012.01.034

Cited by 11 publications

(12 citation statements)

References 9 publications

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“…Age, gender, race, occupation, and presence of complications in donors were not found to be factors affecting SF‐36v2 scores in our study, even though they were significant in other published studies . In the study by Takada et al, it was found that donors who needed repeated outpatient follow‐up visits from prolonged medical complications experienced lower scores .…”

Section: Discussioncontrasting

confidence: 83%

“…Age, gender, race, occupation, and presence of complications in donors were not found to be factors affecting SF-36v2 scores in our study, even though they were significant in other published studies. 18,[22][23][24] In the study by Takada Most donors did not face significant financial issues from the process. In those who did, the cost of medications was the main factor.…”

Section: Discussionmentioning

confidence: 99%

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Health‐related quality of life, clinical outcomes, and subjective experiences of parent donors of pediatric liver transplant recipients

Yuen

Tan

Karthik

et al. 2018

Pediatric Transplantation

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Purpose The understanding of the HRQOL issues for parent donors of children who underwent LDLT is lacking. We evaluated the HRQOL of donor and non‐donor parents, described their subjective experiences and identified factors associated with lower HRQOL post‐donation. Methods This is a cross‐sectional study of parent donors whose children underwent LDLT, using SF‐36v2 Health Survey to measure HRQOL, and a self‐developed questionnaire to evaluate their subjective experiences. Results Of 32 pairs of donor and non‐donor parents, 27 donor and 19 non‐donor parents responded. The data of respondents were analyzed. Both donor and non‐donor parents’ SF‐36v2 norm‐based scores were average or above average as compared to the Singapore population. Donors who made lifestyle changes post‐donation (adopting a healthy balanced diet, regular physical activity, quitting smoking, and moderate alcohol intake) were associated with lower GH (P = 0.009) and PF (P = 0.002) scores. Donors who took more than 3 months for full recovery had lower RP (P = 0.022) and BP scores (P = 0.038). On multivariate analysis, recipient complication of Clavien grade 3 or 4 was associated with increased RP score by 8.71 points (95% CI: 1.74‐15.68), after adjusting for time taken for full recovery. Majority (88.8%) had self‐reported recovery time under 6 months and returned to work within 3 months (74.0%). Conclusions Donors with factors potentially associated with lower HRQOL may need more support to ensure better HRQOL outcomes post‐donation.

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Section: Discussioncontrasting

confidence: 83%

Section: Discussionmentioning

confidence: 99%

Health‐related quality of life, clinical outcomes, and subjective experiences of parent donors of pediatric liver transplant recipients

Yuen

Tan

Karthik

et al. 2018

Pediatric Transplantation

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“…On the other hand, a completely healthy donor is subjected to the risk of morbidity. According to the literature, only 10% of donors have physical symptoms for 1 year after the surgery; morbidity rates ranges from 8.8–23.2% and mortality rates from 0.2–0.9% [2–5].…”

Section: Introductionmentioning

confidence: 99%

Long-Term Health-Related Quality of Life in Living Liver Donors

et al. 2019

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BackgroundIn living donor liver transplantation (LDLT), 2 patients undergo surgery, and the advantages and disadvantages for both patients should be considered. This study evaluated the long-term quality of life in living liver donors, and its impact on their activities of daily living focusing on mood and mental health.Material/MethodsIn total, 101 living liver donors (69 female and 32 male patients, median age of 36.8 years) were surveyed at a median time of 61.8 months after liver donation (range 7–169 months). The generic Short Form Health Survey (SF-36), the Patient Health Questionnaire 9 (PHQ-9), and the Questionnaire of Physical Activity (IPAQ) were used. The results of SF-36 were compared to a matched control group (n=72) using the Wilcoxon test; the SF-36, the PHQ-9, and the IPAQ scores were analyzed using Spearman’s rank correlation. Linear regression model was used to check for dependencies between variables of interest. The IPAQ results were compared between the study group and the general Polish population.ResultsThere were no significant differences in the SF-36 domains between the study group and control group except body pain, which was higher in the living liver donor group (P<0.05). In 30.6% of patients, the PHQ-9 survey revealed mood disturbances. The PHQ-9 scores were higher in female-donors (P<0.05). Both summary scores of the SF-36 correlated to the PHQ-9 (P<0.001). In 89.1% of patients, physical activity was below the population norm and was lower in female donors than in male donors (P<0.01).ConclusionsLDLT had no impact on donors’ physical and mental health. Physical activity of living liver donors was lower than that of the general population. The SF-36 and the IPAQ measures seem to be reliable in the care of living liver donors. The PHQ-9 survey results and the inclination to depression of female living liver donors requires further study.

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“…Other factors, such as individual donor characteristics, urgency of transplantation, donor-recipient emotional closeness, and other stressors, may also exert mediating effects on the decision-making process and contribute decisively to the long-term donor’s emotional stability. 8 , 12 – 14 Unfortunately, a few studies have examined LDLT donors in Asia; 15 – 17 also, a few studies have explored the influence of donation types on the psychological stress of living liver donors.…”

Section: Introductionmentioning

confidence: 99%

Assessment of relevant factors with respect to psychosocial properties in potential living donor candidates before liver transplantation

Wu¹,

Hsu²,

Huang³

et al. 2018

NDT

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BackgroundLiving donor liver transplantation (LDLT) has been developed as one of gold standard treatments for end-stage liver disease. Mental health is a required selection criterion for adult living liver donors and may influence the quality of life after operation.Patients and methodsA total of 1,210 potential living donor candidates for liver transplantation (LT) underwent psychosocial evaluation that included a semi-structured interview, multi-choice self-reported inventory (Beck Depression Inventory-2nd edition [BDI-II], Beck Anxiety Inventory [BAI]), and the family APGAR (Adaptability, Partnership, Growth, Affection, Resolve) index. The test results were compared by family relationships, and subgroups were classified based on the donation type: 1) parents to children, 2) grown children to parents, 3) siblings to siblings, 4) spouses to spouses, and 5) other relatives to other relatives.ResultsThe BDI-II (P < 0.001) and BAI differed considerably according to the donation type in potential donor candidates. Compared with other subgroups, parents donating to their children suffered the most severe psychological stress before LDLT and exhibited more depressive (P < 0.001) and anxiety symptoms. However, the stress associated with grown children donating to their parents, siblings, and spouses was not significantly higher than it was for other relatives. Furthermore, a significant negative correlation existed between family APGAR scores and the severity of depression and anxiety (P < 0.001) among potential donor candidates.ConclusionThese results indicate the importance of understanding potential donor candidates’ psychological characteristics before LT. Greater anxiety and depression may be exhibited by parent donors due to the distress from fears of death or illness of the recipients, or their guilty feeling for their child. Additionally, family dysfunction also revealed more depression and anxiety. Such donor candidates should be given more extensive pre-donation counseling for minimizing pre-LDLT psychological stress.

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Donor Quality of Life After Living Donor Liver Transplantation: Single-Institute Experience

Cited by 11 publications

References 9 publications

Health‐related quality of life, clinical outcomes, and subjective experiences of parent donors of pediatric liver transplant recipients

Health‐related quality of life, clinical outcomes, and subjective experiences of parent donors of pediatric liver transplant recipients

Long-Term Health-Related Quality of Life in Living Liver Donors

Assessment of relevant factors with respect to psychosocial properties in potential living donor candidates before liver transplantation

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